Retraction Note to: miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11

Xu, Qiaolong; Cheng, Li; Jian-yang, Chen; Lu, Wenjie; Wang, Peinian

doi:10.1007/s13577-020-00386-y

Cited by 3 publications

(4 citation statements)

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“…For instance, miR-376a alleviated the development of glioma by negatively regulating KLF15 [46]. In addition, miR-376a suppressed the proliferation and invasion of OS cells by targeting FBXO11 [47]. Interestingly, our study revealed that downregulation of miR-376a distinctly promoted the proliferation and migration of OS cell lines.…”

Section: Discussionmentioning

confidence: 68%

Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway

Xie

Chang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Allicin, an organic sulfur compound extracted from the bulb of Allium sativum, can potentially prevent various tumors. Our previous study found that allicin can effectively suppress the proliferation of osteosarcoma cells. However, the molecular mechanisms have not been illustrated. In this study, Saos-2 and U2OS osteosarcoma cells were used to investigate the underlying mechanisms. A series of experiments were carried out to authenticate the anticancer property of allicin. Knockdown of lncRNA MALAT1 inhibited the proliferation, invasion and migration and promoted apoptosis of osteosarcoma cells. Knockdown of miR-376a increased the proliferation, invasion, and migration and dropped apoptosis of osteosarcoma cells. Furthermore, knockdown of miR-376a reversed the influences of MALAT1 silencing in osteosarcoma cells. Based on our data, MALAT1 could downregulate the expression of miR-376a, subsequently accelerating osteosarcoma. Moreover, oxidative stress and autophagy were identified as the potential key pathway of allicin. Allicin inhibited osteosarcoma growth and promoted oxidative stress and autophagy via MALATI-miR-376a. We also found that allicin promotes oxidative stress and autophagy to inhibit osteosarcoma growth by inhibiting the Wnt/β-catenin pathway in vivo and in vitro. All data showed that allicin promotes oxidative stress and autophagy of osteosarcoma via the MALATI-miR-376a-Wnt/β-catenin pathway.

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Section: Discussionmentioning

confidence: 68%

Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway

Xie

Chang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…As an important miRNA, miR-376a-3p has been revealed to function as a tumor suppressor in renal tumor development by targeting SGK3 (32). miR-376a-3p was lowly expressed in osteosarcoma cell lines, and inhibited cell proliferation and invasion by silencing FBXO11 expression (34). Serum miR-376a-3p expression was revealed to be markedly higher in ovarian cancer patients in comparison with that in healthy ones, and miR-376-3p was identified as a biomarker of ovarian cancer diagnosis and treatment (33).…”

Section: Discussionmentioning

confidence: 99%

“…miR-376a-3p instead of other potential targets was selected for the following two reasons: Firstly, the predicted top 10 miRNAs were verified by luciferase reporter activity assay, and it was revealed that 6 miRNAs including miR-376a-3p were significantly regulated by TTN-AS1. Secondly, miR-376a-3p has been identified as a tumor suppressor in a series of cancer types ( 32 – 34 ). However, the other 5 miRNAs have not been reported to be related in the development of multiple cancer types.…”

Section: Discussionmentioning

confidence: 99%

LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p

Shen

Yinyin

et al. 2020

Oncol Rep

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Increasing research has demonstrated that lncRNAs participate in the development of multiple cancer types. However, the role of TTN-AS1 in endometrial cancer (EC) remains unknown. The present study aimed to explore the function of titin-antisense RNA1 (TTN-AS1) in EC progression and the underlying mechanisms. qRT-PCR was performed to assess the TTN-AS1 expression patterns in EC tissues and cell lines. Loss of function experiments were carried out to estimate the effects of TTN-AS1 on EC cell proliferation, migration and invasion. To reveal the underlying mechanisms, informatics tools were used to predict the targets. Rescue experiments were performed to investigate the TTN-AS1-regulated miR-376a-3p/pumilio homolog 2 (PUM2) axis involved. The results of the present study revealed that TTN-AS1 was highly expressed in both EC tissues and cell lines, and TTN-AS1 knockdown inhibited EC cell proliferation, migration and invasion. With respect to the mechanisms, miR-376a-3p was revealed to be targeted by TTN-AS1, and reversed the effects on EC development induced by TTN-AS1. In addition, PUM2 was positively regulated by TTN-AS1, and miR-376a-3p mediated the regulation between them. Furtherly, in vivo experiments confirmed the results. Collectively, TTN-AS1 enhanced EC cell proliferation and metastasis by targeting the miR-376a-3p/PUM2 axis, which may shed light on EC diagnosis and treatment.

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“…Overexpression or low expression of oncogenic or tumor suppressor miRNA is crucial in the progression of tumor development because the miRNA implicates in proliferation, apoptosis [5], autophagy [6], migration [7], and invasion [8]. To date, several miRNAs are reported to play a critical role in the tumorigenesis of OS; for example, miR-182-3p [9], miR-491-3p [10], and miR-376a [11] act as tumor suppressors while miR-33a [12] functions as an oncogene. However, further studies about the relationship between miRNA and OS are still needed for the controversy about the role of the miRNA.…”

Section: Introductionmentioning

confidence: 99%

miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2

Guo

Peng

et al. 2019

BioMed Research International

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Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents with a poor prognosis. Though miR-509-5p has been reported as a tumor suppressor in several human cancers, the role of miR-509-5p in OS remains unclear. In this study, our result of real-time PCR (RT-PCR) showed that the expression of miR-509-5p was significantly decreased in OS tissues and cell lines. Overexpression of miR-509-5p significantly suppressed cell proliferation and invasion in OS cell lines. Moreover, we identified tribbles homolog 2 (TRIB2) as the direct target of miR-509-5p. Knockdown of TRIB2 could inhibit the malignant capacity of OS cells. At last, we reported that TRIB2 could inhibit the bioactivity of the tumor suppressor gene p21 via blocking its transcriptional activity. Collectively, our study revealed that miR-509-5p functions as a tumor suppressor by targeting TRIB2 in OS and thus could affect the activity of p21, suggesting that miR-509-5p is a novel preventive intervention for OS patients.

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Retraction Note to: miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11

Cited by 3 publications

References 1 publication

Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway

Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway

LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p

miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2

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