Retraction Note to: Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer

Shashni, Babita; Sharma, Karun; Singh, R. V.; Sakharkar, Kishore R.; Dhillon, Sarinder Kaur; Nagasaki, Yukio; Sakharkar, Meena Kishore

doi:10.1186/s12864-022-08371-5

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Additionally, caffeine not only affects immune cells, such as T and B lymphocytes, NK cells and macrophages, but also affects cytokines, such as TNF-α and IL-2, which have a variety of functions, to improve immunity in the body (68) . Moreover, caffeine may represent a therapeutic agent for BC by activating apoptosis-inducing mechanisms (69) . Therefore, the intake of decaffeinated coffee is not as effective as total coffee consumption, and similar results have been reported in published studies (70)(71) .…”

Section: Discussionmentioning

confidence: 99%

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

Shu

Yang

et al. 2021

Public Health Nutr.

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Objective: We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis. Design: Systematic review and network meta-analysis. Setting: We conducted a systematic review of electronic publications in the last 30 years to identify case–control studies or prospective cohort studies that evaluated the effects of coffee and tea intake. Results: Forty-five studies that included more than 3 323 288 participants were eligible for analysis. Network meta-analysis was performed to determine the effects of coffee and/or tea consumption on reducing BC risk in a dose-dependent manner and differences in coffee/tea type, menopause status, hormone receptor and the BMI in subgroup and meta-regression analyses. According to the first pairwise meta-analysis, low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)− BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2–3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women. Conclusions: Coffee and tea consumption is not associated with a reduction in the overall BC risk in postmenopausal women and is associated with a potentially lower risk of ER− BC. And the highest recommended dose is 2–3 cups of coffee/d or ≥5 cups of tea/d. They are potentially useful dietary protectants for preventing BC.

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Section: Discussionmentioning

confidence: 99%

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

Shu

Yang

et al. 2021

Public Health Nutr.

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“…Hydroxyl hydroquinone (HHQ) is another coffee compound potentially useful for breast cancer treatment. HHQ isolated from coffee inhibited growth of MDA-MB-231 and MCF-7 cells with half maximal inhibitory concentration (IC 50 ) value of 25 μM/ml and 50 μM/ml, respectively [80]. The study showed that HHQ induced ROS generation as well as compromised the permeability of mitochondria membrane.…”

Section: Breast Cancermentioning

confidence: 94%

Coffee in cancer chemoprevention: an updated review

Ismail

Zeppa

Akhtar

et al. 2020

Expert Opinion on Drug Metabolism & Toxicology

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Introduction: Chemoprevention of cancer refers to the use of natural or synthetic compounds to abolish or perturb a variety of steps in tumor initiation, promotion, and progression. This can be realized through different mechanisms, including activation of free radical scavenging enzymes, control of chronic inflammation, and downregulation of specific signaling pathways. Areas covered: The goal of this article is to critically review recent evidence on association between coffee and prevention of different types of cancer, with particular emphasis on the molecular mechanisms and the bioactive compounds involved in its anticancer activity. Expert opinion: Coffee is a mixture of different compounds able to decrease the risk of many types of cancer. However, its potential anticancer activity is not completely understood. Hundreds of biologically active components such as caffeine, chlorogenic acid, diterpenes are contained in coffee. Further research is needed to fully elucidate the molecular mechanisms underlying the anticancer effects of coffee and fully understand the role of different confounding factors playing a role in its reported anticancer activity.

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“…The activity, efficacy and safety of deoxyarbutin dA is safer and less cytotoxic compared with hydroquinone [96]. Based on in vitro experiments against mushroom tyrosinase, it turns out that dA effectively inhibits mushroom tyrosinase with Ki 10 times lower than hydroquinone and 350 times lower than arbutin.…”

Section: Fig 2: Conversion Of Arbutin Compound Into Damentioning

confidence: 99%

The Recent Update of Deoxyarbutin: A Skin Depigmentation Agent With Tyrosinase Inhibition Targeting

Muchtaridi

Dewi

2020

Int J App Pharm

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Melanin is produced through the process of melanogenesis, which serves to protect the skin from the damaging effects of UV radiation. Abnormal accumulation of melanin will aesthetically disturb even interfere with health. One of the clinical manifestations of abnormal accumulation of melanin is the incidence of melasma. Some of the tyrosinase enzyme inhibitor agents most widely used as Hydroquinone, Kojic acid and Arbutin do not give satisfactory results and cause serious side effects. Hydroquinone is known to cause ochronosis exogenous and cytotoxic. Kojic acid is known to cause allergies and mutagenic, while arbutinisis is known to have cytotoxic properties lower than hydroquinone, but less satisfactory depigmentation activity. There was a compound that has been synthesized by removing the hydroxy group of arbutin, known as deoxyarbutin (4-[Tetrahydro-2H-Pyrans-2-yl) oxy] phenol). Deoxyarbutin (dA) shows Ki 10-fold is lower than hydroquinone and 350-fold is lower than arbutin. IC50dA is 17.5+0.5 µmol/l, while the IC50 hydroquinone is 73.7+9.1 µmol/l. In terms of security, dA indicates that cell viability is 95% higher than hydroquinone. However, dA is thermolabile and photolabile. Several studies have shown satisfactory results to improve the stability of dA, that these compounds are considerable potential for further development as a depigmentation agent. The aim of this review is to describe how the potency of dA as a tyrosinase inhibitor interferes melanogenesis process through the latest depigmentation agent, its safety, efficacy and stability.

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Retraction Note to: Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer

Abstract: This article has been retracted. Please see the Retraction Notice for more detail:

Cited by 5 publications

References 2 publications

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis

Coffee in cancer chemoprevention: an updated review

The Recent Update of Deoxyarbutin: A Skin Depigmentation Agent With Tyrosinase Inhibition Targeting

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