Retraction Note to: Associations of IL-8 gene polymorphisms and IL-8 levels with predisposition to age-related macular degeneration: a meta-analysis

Liu, Jianhui; Tian, Zhi-Qing; Li, Jinhui; Zhao, Gansen

doi:10.1007/s40520-020-01720-y

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Interleukin-8 (Ll-8)1

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2021

2023

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Cited by 2 publications

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“…A meta-analysis suggested that IL-8 +781 C/T polymorphism affects predisposition to AMD and wet AMD. Moreover, patients with AMD and wet AMD also present elevated IL-8 levels (116). A case-control study suggested a possible secondary role of IL-8 gene in the development of AMD and regarded IL-8 as a new susceptibility genomic biomarker of AMD (117).…”

Section: Interleukin-8 (Ll-8)mentioning

confidence: 99%

Transcription Factor NF-κβ and Molecules Derived from its Activation in Age-Related Macular Degeneration

Torres

Luchini³

et al. 2021

Integr J Med Sci

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Activation of the nuclear factor kappa β (NF-κβ) is related to many inflammatory diseases, including age-related macular degeneration (AMD). The imbalance in the redox state, which happens mainly in senescence, associated with several peculiar characteristics of the macular region, has led to studies of this molecule for AMD therapeutic interventions. Findings report the involvement of NF-κβ both in the triggering as well as in the worsening condition of AMD. The present article correlates AMD oxidant and inflammatory genesis with the action of the nuclear factor kappa β. Besides its mechanism of action, this study also analyzes the main inflammatory cytokines and adhesion molecules that may be activated by NF-κβ and are closely related to AMD.

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Section: Interleukin-8 (Ll-8)mentioning

confidence: 99%