Retraction Note: microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2

Liu, Wei; Shi, Xiaoming; Wang, Bao-Liang

doi:10.1038/s41417-023-00649-4

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, Wnt and Notch pathways are two well-characterized oncogenic pathways in OSCC development. 20 , 21 Therefore, we chose these pathways in the present experiment to determine whether CCT6A regulated these two pathways to induce OSCC cell malignant behaviors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma

Chen,

Liu

2023

Cancer Biology & Therapy

View full text Add to dashboard Cite

Chaperonin containing TCP1 subunit 6A (CCT6A) was recently discovered to be involved in cancer pathogenesis and stemness; however, its role in oral squamous cell carcinoma (OSCC) has not been reported. The current study aimed to investigate the impact of CCT6A on OSCC cell malignant behaviors and stemness and to explore its potentially interreacted pathways. SCC-15 and HSC-3 cells were transfected with the plasmid loading control overexpression, CCT6A overexpression, control knockout, or CCT6A knockout. Wnt4 overexpression or Notch1 overexpression plasmids were transfected into CCT6A-knockout SCC-15 cells. Cell proliferation, apoptosis, invasion, stemness, Notch, and Wnt pathways were detected in both cell lines, whereas RNA sequencing was only performed in SCC-15 cells. CCT6A was upregulated in five OSCC cell lines, including SCC-15, HSC-3, SAT, SCC-9, and KON, compared to that in the control cell line. In SCC-15 and HSC-3 cells, CCT6A overexpression increased cell proliferation, invasion, sphere formation, CD133, and Sox2 expression, but decreased cell apoptosis; on the contrary, CCT6A knockout exhibited an opposite effect on the above indexes. RNA-sequencing data revealed that the Wnt and Notch pathways were involved in the CCT6A’effect on SCC-15 cell functions. CCT6A positively regulates the Wnt and Notch pathways in SCC-15 and HSC-3 cells. Importantly, it was shown that activation of the Wnt or Notch pathways attenuated the effect of CCT6A knockout on SCC-15 cell survival, invasion, and stemness. CCT6A may promote OSCC malignant behavior and stemness by activating the Wnt and Notch pathways.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The Notch and Wnt signaling pathways have been confirmed to be closely involved in the malignant progression of OSCC. 20 , 21 Therefore, the expression of Notch1, Hes1, Wnt4, and β-catenin in SCC-15 and HSC-3 cells (Normal, OE-NC, OE-CCT6A, KO-NC and KO-CCT6A groups) was evaluated.…”

Section: Methodsmentioning

confidence: 99%

Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma

Chen,

Liu

2023

Cancer Biology & Therapy

View full text Add to dashboard Cite

show abstract

Retraction Note: microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2

Cited by 1 publication

References 0 publications

Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma

Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma

Contact Info

Product

Resources

About