Retraction Note: Human cathelicidin LL-37 enhance the antibiofilm effect of EGCG on Streptococcus mutans

Guo, Yi; Zhang, Bo; Feng, Xue-song; Ren, Hui-xun; Xu, Jiru

doi:10.1186/s12903-017-0392-3

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…hBD3 showed a promising antimicrobial effect among hBDs (Joly et al., 2004). Two other natural antimicrobial peptides, Histatin‐5 (Krzysciak et al., 2015) and cathelicidin (LL37; Guo et al., 2016) have also been proved to be effective against S. mutans . Most studies were in vitro and reported their findings base on planktonic bacteria.…”

Section: Inhibition Of Cariogenic Species and Promotion Of Pulp Tissue Healingmentioning

confidence: 99%

The multifaceted roles of antimicrobial peptides in oral diseases

Niu

Yin

Mei

et al. 2021

Molecular Oral Microbiology

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Antimicrobial peptides are naturally occurring protein molecules with antibacterial, antiviral and/or antifungal activity. Some antimicrobial peptides kill microorganisms through direct binding with negatively charged microbial surfaces. This action disrupts the cytoplasmic membrane and leads to the leakage of the cytoplasm. In addition, they are involved in the innate immune response. Antimicrobial peptides play an important role in oral health, as natural antimicrobial peptides are the first line of host defence in response to microbial infection. The level of natural antimicrobial peptides increases during severe disease conditions and play a role in promoting the healing of oral tissues. However, they are insufficient for eliminating pathogenic micro-organisms. The variability of the oral environment can markedly reduce the effect of natural antimicrobial peptides. Thus, researchers are developing synthetic antimicrobial peptides with promising stability and biocompatibility. Synthetic antimicrobial peptides are a potential alternative to traditional antimicrobial therapy.Pertinent to oral diseases, the deregulation of antimicrobial peptides is involved in the pathogenesis of dental caries, periodontal disease, mucosal disease and oral cancer, where they can kill pathogenic microorganisms, promote tissue healing, serve as biomarkers and inhibit tumor cells. This narrative review provides an overview of the multifaceted roles of antimicrobial peptides in oral diseases.

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Section: Inhibition Of Cariogenic Species and Promotion Of Pulp Tissue Healingmentioning

confidence: 99%

The multifaceted roles of antimicrobial peptides in oral diseases

Niu

Yin

Mei

et al. 2021

Molecular Oral Microbiology

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show abstract

“…Epidemiological studies have suggested green tea has a positive effect on cancer prevention in certain types of cancer, namely breast, colon, and skin [72][73][74] . Although there is lesser or no positive clinical effect seen with other types of gastrointestinal or oral cancers, there is bactericidal activity against Escherichia coli, Streptococcus salivarius, and Streptococcus mutans [75][76][77] .…”

Section: Chemical and Pharmacological Propertiesmentioning

confidence: 99%

Phytochemicals and cancer chemoprevention

Dave¹,

Parande²,

Park³

et al. 2020

JCMT

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The unending morbidity and mortality that results from cancer, as well as adverse reactions due to chemotherapy and the enormous economic burden of treatment and hospitalization, advocates for the necessity of chemopreventive measures. Cancer chemoprevention refers to the use of agents capable of reversing, reducing, or slowing down the pathology of cancer at various stages. Fortunately, a few therapeutic drugs with relatively low toxicity (e.g., tamoxifen, finasteride), and a sparse number of vaccines (hepatitis B, HPV), are used to prevent specific cancers. In the general population, however, therapeutic options for cancer prevention are not common. Nonetheless, it is generally agreed that diet affects the genesis of cancer, and phytochemicals have the capacity of functioning as cancer chemoprevention agents. This is supported by epidemiological studies and clearly documented with animal models designed to mimic human carcinogenesis. Additionally, some public health strategies, such as recommendations for greater consumption of fruits and vegetables, reflect the merits of cancer chemoprevention. Here, we focus on some well-established natural product cancer chemopreventive agents, including resveratrol (grapes), epigallocatechin-3-gallate (green tea), sulforaphane (cruciferous vegetables), anthocyanins (grapes and berries), curcumin (turmeric), silibinin (milk thistle), and lycopene (tomatoes). As aptly demonstrated by genomic analysis and other methods, the mechanistic underpinning is variable and complex. In addition, responses may be mediated through indirect mechanisms, such as interaction with the microbiome. Furthermore, ancillary applications of chemopreventive agents are worthy of consideration, such as management of sequelae induced by chemotherapy. Recognizing the loss of millions of cancer patients every year, it is obvious that negating malignant metastatic conditions remains of paramount importance. In meeting this objective, cancer chemoprevention offers great promise.

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Advances in Vitamin D and Infectious Diseases

王¹

2022

ACM

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Retraction Note: Human cathelicidin LL-37 enhance the antibiofilm effect of EGCG on Streptococcus mutans

Cited by 3 publications

References 2 publications

The multifaceted roles of antimicrobial peptides in oral diseases

The multifaceted roles of antimicrobial peptides in oral diseases

Phytochemicals and cancer chemoprevention

Advances in Vitamin D and Infectious Diseases

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