Retraction Note: BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway

Feng, Pengcheng; Ke, Xing-Fei; Kuang, Hui-Lan; Pan, Lili; Ye, Qiang; Jianbing, WU

doi:10.1186/s13287-022-02841-z

Cited by 2 publications

(2 citation statements)

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“…We also found multiple instances of overlap between some of the EdU assay images used for Figures 2B, 3G and 5D and data published by other authors in 2018 and 2019 [1][2][3][4]. Unexpectedly, the images of rulers (with specific imperfections) used to illustrate tumor size duplicate such images from two unrelated papers [5,6]. Consequently, all authors agreed that the article should be retracted.…”

mentioning

confidence: 73%

Retraction: Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN

Li,

Wang,

et al. 2024

Aging

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mentioning

confidence: 73%

Retraction: Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN

Li,

Wang,

et al. 2024

Aging

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“…Therefore, the active constituents of A. cantoniensis Hance can also play a role in the treatment of hepatitis E by regulating TNF signaling pathway. In addition, the MAPK signaling pathway can also mediate the development of liver diseases ( 20 ), and the active ingredients of the A. cantoniensis Hance can regulate the above inflammatory signaling pathway, thus playing a potential therapeutic role.…”

Section: Discussionmentioning

confidence: 99%

Exploring the potential targets of the Abrus cantoniensis Hance in the treatment of hepatitis E based on network pharmacology

Wang

Luan

et al. 2023

Front. Vet. Sci.

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Hepatitis E is a disease of public health significance caused by the cross-species transmission of zoonotic hepatitis E virus (HEV) infection. There are no specific drugs. In this study, network pharmacology was used to reveal the mechanism of treatment of the active constituents of the Abrus cantoniensis Hance on hepatitis E. Based on the previously published representative components of A. cantoniensis Hance, we were screened the active components with OB ≥ 20% and DL ≥ 0.1 in A. cantoniensis Hance based on the TCMSP, predicted the target online through Swiss target prediction, and integrated the hepatitis E target in the GeneCards and DisGenet databases. Then, the core target was screened and the GO and KEGG enrichment and the network of the drug-active-ingredient-disease-pathway-target analysis were performed by the Cytoscape software. There were 11,046 hepatitis E targets, including PI3K-AKt, SRC, MAPK, PTPN11, EGFR, STAT1 and so on. The core ingredients include Oleanolic acid, Butin, β-sitosterol, Soyasapogenol E, 5,7-dihydroxy-2-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one, Stigmasterol, Emodin, Physcion, and Enoxolone. A total of 1,410 GO enrichment results of core targets, including 1,246 biological process, 51 cell composition and 113 molecular function results. KEGG pathway was enriched in 150 related pathways, suggesting that A. cantoniensis Hance acts on cancer signaling pathway, endocrine resistance pathway, PI3K-AKt signaling pathway, MAPK, TNF and other signaling pathway. Through key components such as Oleanolic acid, Butin, β-sitosterol, Stigmasterol, and Enoxolone and other components interferes with AKT1, IL-6 and TNF, and regulates pathway in cancer, PI3K-AKt signaling pathway and MAPK pathway to play a therapeutic role in hepatitis E.

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Retraction Note: BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway

Cited by 2 publications

References 1 publication

Retraction: Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN

Retraction: Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN

Exploring the potential targets of the Abrus cantoniensis Hance in the treatment of hepatitis E based on network pharmacology

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