Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass

Palmieri, Michela; Joseph, Teenamol E; O’Brien, Charles A.; Gómez-Acevedo, Horacio; Manolagas, Stavros C.; Ambrogini, Elena

doi:10.1371/journal.pone.0290458

Cited by 1 publication

(1 citation statement)

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“…Morever, osteoblast and osteoclast-related mRNAs of KO mice greatly decreased compared to WT mice, suggesting that Scarb1 is required for normal bone differentiation. More strangely, the latest research from Palmieri M et al (2023a;2023b) reported that bone mass was not affected in Scarb1 KO mice and thought Scarb1 did not contribute to bone homeostasis. However, it is established that HDL, via its main protein component apolipoprotein A1, is essential for normal bone formation by affecting osteoblast (Blair et al, 2016;Papachristou et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Unveiling the common loci for six body measurement traits in Chinese Wenshan cattle

Ren,

He,

et al. 2023

Front. Genet.

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Introduction: Body measurement traits are integral in cattle production, serving as pivotal criteria for breeding selection. Wenshan cattle, a local breed in China’s Yunnan province, exhibit remarkable genetic diversity. However, the molecular mechanisms regulating body measurement traits in Wenshan cattle remain unexplored.Methods: In this study, we performed a genome-wide association method to identify genetic architecture for body height body length hip height back height (BAH), waist height and ischial tuberosity height using the Bovine 50 K single nucleotide polymorphism Array in 1060 Wenshan cattles.Results: This analysis reveals 8 significant SNPs identified through the mixed linear model (MLM), with 6 SNPs are associated with multiple traits and 4 SNPs are associated with all 6 traits. Furthermore, we pinpoint 21 candidate genes located in proximity to or within these significant SNPs. Among them, Scarb1, acetoacetyl-CoA synthetase and HIVEP3 were implicated in bone formation and rarely encountered in livestock body measurement traits, emerge as potential candidate genes regulating body measurement traits in Wenshan cattle.Discussion: This investigation provides valuable insights into the genetic mechanisms underpinning body measurement traits in this unique cattle breed, paving the way for further research in this domain.

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