Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621.

Mehra, Mandeep R.; Desai, Sapan S.; Kuy, Srey Ram; Henry, Timothy D.; Patel, Amit N.

doi:10.1056/nejmc2021225

Cited by 412 publications

(98 citation statements)

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“…The appropriate scoping of methods for real-world data studies is critical for the use of these valuable, emerging data sets. We have just witnessed the retraction of two data-driven COVID-19 studies from two of the most prominent clinical journals because of uncertainty about the provenance and quality of the data 4,5 . But the issue goes far beyond these two papers, as data provenance and analytical approaches are often not appropriately detailed in the methods of scientific publications.…”

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confidence: 99%

Agile analytics to support rapid knowledge pipelines

2020

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confidence: 99%

Agile analytics to support rapid knowledge pipelines

2020

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“…Recently, two worldrenowned medical journals, The New England Journal of Medicine and The Lancet retracted two high-profile papers on treatments in patients with COVID-19. 31,32 One of the studies reported the results of clinical trials of two antimalarial drugs used for treatment of COVID-19 (chloroquine and hydroxychloroquine). 32 This retracted study claimed that these drugs were not associated with improved outcomes and were, in fact, associated with higher mortality in patients.…”

Section: Role Of Journals During a Public Health Crisismentioning

confidence: 99%

Dissemination of Information During Public Health Crises: Early COVID‐19 Data From The Laryngoscope

Chern

Selesnick

2020

The Laryngoscope

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Objectives: During a public health crisis, it is important for medical journals to share information in a timely manner while maintaining a robust peer-review process. This review reports and analyzes The Laryngoscope's publication trends and practices during the COVID-19 pandemic, before the COVID-19 pandemic, and during previous pandemics. Methods: Comprehensive review of two databases (PubMed and The Laryngoscope) was performed. COVID-19 manuscripts (published in The Laryngoscope during the first 4 months of the pandemic) were identified and compared to manuscripts pertaining to historic pandemics (published in The Laryngoscope during the first 2 years of each outbreak). Keywords included "Laryngoscope", "flu", "pandemic", "influenza", "SARS", "severe acute respiratory syndrome", "coronavirus", "COVID-19", and "SARS-CoV-2". Data were obtained from The Laryngoscope to characterize publication trends during and before the COVID-19 pandemic.

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“…Two papers have been recently published in two of the most prestigious medical journals only to be retracted a few weeks later. The first onepublished on The New England Journal of Medicine (NEJM) on 1 May 2020-addressed the lack of harmful effects of ACE inhibitors and angiotensin receptor blockers in patients with COVID-19 4 ; the other-published on Lancet on 22 May 2020focused on the potential risks of using hydroxychloroquine (HCQ) or chloroquine as COVID-19 treatment. 5 These two papers share three authors (Professor Mandeep R Mehra, Dr Sepan S Desai and Dr Amit N Patel) 4 5 and also the source of the data analysed: Surgisphere, a data analytics company founded by Dr Desai in 2007.…”

Section: A Brief Introduction To Recent Events: the Surgisphere Scandalmentioning

confidence: 99%

Frauds in scientific research and how to possibly overcome them

et al. 2020

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Frauds and misconduct have been common in the history of science. Recent events connected to the COVID-19 pandemic have highlighted how the risks and consequences of this are no longer acceptable. Two papers, addressing the treatment of COVID-19, have been published in two of the most prestigious medical journals; the authors declared to have analysed electronic health records from a private corporation, which apparently collected data of tens of thousands of patients, coming from hundreds of hospitals. Both papers have been retracted a few weeks later. When such events happen, the confidence of the population in scientific research is likely to be weakened. This paper highlights how the current system endangers the reliability of scientific research, and the very foundations of the trust system on which modern healthcare is based. Having shed light on the dangers of a system without appropriate monitoring, the proposed analysis suggests to strengthen the existing journal policies and improve the research process using new technologies supporting control activities by public authorities. Among these solutions, we mention the promising aspects of the blockchain technology which seems a promising solution to avoid the repetition of the mistakes linked to the recent and past history of research.

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Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621.

Cited by 412 publications

References 1 publication

Agile analytics to support rapid knowledge pipelines

Agile analytics to support rapid knowledge pipelines

Dissemination of Information During Public Health Crises: Early COVID‐19 Data From The Laryngoscope

Frauds in scientific research and how to possibly overcome them

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