Retraction: Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis <i>in vivo</i>

Daley, William P.; Matsumoto, Kazue; Doyle, Andrew D.; Wang, Shaohe; DuChez, Brian J.; Holmbeck, Kenn; Yamada, Kenneth M.

doi:10.1242/dev.195560

Cited by 2 publications

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“…Thus, when BTBD7 is knocked out, Snail2 expression and cleft formation are inhibited, resulting in reduced bud formation and branching inhibition (Figure 1). William P. Daley et al performed in vitro MDCK cell mock ectoblast experiments in which they found 29 that activated BTBD7 provided a mechanical link between the extracellular matrix and fissure growth. BTBD7 locally promotes epithelial branch morphogenesis by promoting Snail2(Slug) and inhibiting E-cadherin.…”

Section: Effects Of Btbd7 In Normal Tissuesmentioning

confidence: 99%

The Role of BTBD7 in Normal Development and Tumor Progression

Liu

Song

et al. 2023

Technol Cancer Res Treat

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BTB/POZ domain-containing protein 7 (BTBD7) has a relative molecular weight of 126KD and contains two conserved BTB/POZ protein sequences. BTBD7 has been shown to play an essential role in normal human development, precancerous lesions, heat-stress response, and tumor progression. BTBD7 promotes branching morphogenesis during development and participates in the salivary gland, lung, and tooth formation. Furthermore, many studies have shown that aberrant expression of BTBD7 promotes heat stress response and the progression of precancerous lesions. BTBD7 has also been found to play an important role in cancer. High expression of BTBD7 affects tumor progression by regulating multiple pathways. Therefore, a complete understanding of BTBD7 is crucial for exploring human development and tumor progression. This paper reviews the research progress of BTBD7, which lays a foundation for the application of BTBD7 in regenerative medicine and as a biomarker for tumor prediction or potential therapeutic target.

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Section: Effects Of Btbd7 In Normal Tissuesmentioning

confidence: 99%

The Role of BTBD7 in Normal Development and Tumor Progression

Liu

Song

et al. 2023

Technol Cancer Res Treat

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“…Thirdly, a cadherin gene (Cdh1) appeared partially duplicated, in addition to Pcdh10 evolving under positive selection. Cdh1 expression is also known to be regulated by Btbd7 (Daley et al 2017), a gene found to be positively selected in H. formosa. Finally, a relatively large duplication containing the majority of the Camk2g gene and a small part of the Ccdc88a gene was observed.…”

Section: Gene Duplicationsmentioning

confidence: 99%

The genomics of placenta evolution in livebearing fish

Kruistum

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During vertebrate evolution, complex organs have evolved several times. The development of these organs is encoded in the genome. However, it is currently unclear how new complex organs, consisting of multiple interlocking parts, can evolve as a result of genomic change. In this thesis, I aim to find the genomic basis of one such newly evolved organ: the placenta in the livebearing fish family Poeciliidae. In this family, a placenta has evolved nine times independently, allowing for the investigation of multiple evolutionary origins of the same organ within a single group of species. First, I sequence and assemble the genomes of both placental and non-placental poeciliid species. Then, I compare the genomes of placental species with the genomes of non-placental species, aiming to find consistent genomic differences between placental and non-placental species that can be associated with placenta evolution. I show that indeed, placental species show consistent mutations in both protein-coding and regulatory regions of the genome. Protein-coding mutations occur mainly around structural and metabolic genes, while regulatory changes occur mainly around developmental genes. I also show that, contrary to some predictions, gene duplications are not associated with placenta evolution in poeciliid fish. Finally, I show that allele-specific DNA methylation is present in the poeciliid fish Poeciliopsis gracilis, and that its inheritance is nonrandom but instead depends on parent-of-origin of the methylated allele, suggesting genomic imprinting. Together I provide a comprehensive overview of genome evolution in the fish family Poeciliidae, and provide new insights into the evolution of complex traits.

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Retraction: Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo

Cited by 2 publications

References 0 publications

The Role of BTBD7 in Normal Development and Tumor Progression

The Role of BTBD7 in Normal Development and Tumor Progression

The genomics of placenta evolution in livebearing fish

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