In this study, vacuum oxygen plasma was applied to enhance the comfort properties of polyester/ cotton (P/C) blend fabric (65/35%) for tropical climatic conditions. In addition, air and argon plasma were used to examine the aging effect by TEGEWA drop test. Taguchi method was employed to design the experiment and analyze the largest influential variable as well as optimal parameter levels. More attention was given to the evaluation of wickability, water vapour permeability/resistance, air permeability and surface characterization. Results revealed that all plasma treated comfort properties enhanced except air permeability of experimental runs at 1O 2 and 7O 2 . Specifically, wickability of fabric increased at least by 43.25% and 37.63% in warp and weft directions, correspondingly, within 5 min of wicking time, whereas the thermal resistance reduced at least by 20.16%. The SEM images depicted the formation of cracks, grooves, nanostructures and high degree of roughness on plasma treated surfaces.