Retraction: Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Shi, Yuanfei; Chen, Weishan; Li, Qinghuai; Ye, Zhaoming

doi:10.18632/oncotarget.17877

Cited by 1 publication

(3 citation statements)

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“…The short AR CAG repeat length might be a risk factor for osteosarcoma in the Chinese population. [12] Compared with the incidence of bone tumors in 2014, the incidence in 2015 increased by 0.01 per 100,000, but there was no change in the ASIRC and ASIRW. [13] Global incidence of primary malignant bone tumor data shows two peaks: one is in the second decade of life and the other is in the seventh and eighth decades of life.…”

Section: Discussionmentioning

confidence: 94%

“…Sex differences in primary malignant bone tumors incidence may be due to hormonal regulation; specifically, the androgen receptor (AR) with CAG and GGN repeat length variation may contribute to tumorigenesis and osteosarcoma. The short AR CAG repeat length might be a risk factor for osteosarcoma in the Chinese population [12] . Compared with the incidence of bone tumors in 2014, the incidence in 2015 increased by 0.01 per 100,000, but there was no change in the ASIRC and ASIRW [13] …”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Primary malignant bone tumors incidence, mortality, and trends in China from 2000 to 2015

Xi,

Qiao,

et al. 2023

Chinese Medical Journal

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Background: Primary malignant bone tumors are uncommon, and their epidemiological features are rarely reported. We aimed to study the incidence and death characteristics of bone tumors from 2000 to 2015. Methods: Population-based cancer registries submitted registry data to National Central Cancer Registry of China (NCCRC). The data collected from 501 local cancer registries in China were assessed using NCCRC screening methods and criteria. Incidence and mortality rates of primary bone tumor were stratified by age group, gender, and area. Age-standardized incidence and mortality rates were adjusted using the Chinese standard population in 2000 and Segi's world population. The annual percentage change (APC) in rate was calculated using the Joinpoint Regression Program. Results: Data from 368 registries met quality control criteria, of which 134 and 234 were from urban and rural areas, respectively. The data covered 309,553,499 persons. The crude incidence, age-standardized incidence, and crude mortality rates were 1.77, 1.35, and 1.31 per 100,000, respectively. Incidence and mortality rates were higher in males than those in females; they showed downward trends, with declines of 2.2% and 4.8% per year, respectively, and the rates in urban areas were lower than those in rural areas. Significant declining trends were observed in urban areas. Stable trends were seen in rural areas during 2000 to 2007, followed by downward trends. Age-specific incidence and mortality rates showed stable trends in the age group of 0 to 19 years, and downward trends in the age group elder than 19 years. Conclusions: The incidence and mortality rates of primary malignant bone tumors in rural areas were higher compared to those in urban areas. Targeted prevention measures are required to monitor and control bone tumor incidence and improve the quality of life of affected patients. This research can provide a scientific basis for the prevention and control of bone tumors, as well as basic information for follow-up research.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%