Retraction: A multifunctional self-dissociative polyethyleneimine derivative coating polymer for enhancing the gene transfection efficiency of DNA/polyethyleneimine polyplexes <i>in vitro</i> and <i>in vivo</i>

Wang, Cheng; Bao, Xiuli; Ding, Xuefang; Ding, Yang; Abbad, Sarra; Wang, Yazhe; Li, Min; Su, Yujie; Wang, Wei; Zhou, Jianping

doi:10.1039/d0py90010a

Cited by 16 publications

(19 citation statements)

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“…Moreover, body weight variations of mice in different groups also revealed some interesting results. As shown in Figure 6(B), no significant decline in body weight was observed in CM/SLN/ICG group, suggesting that the preferable tumour homing of CM/ SLN/ICG could increase its anticancer efficacy while reducing the undesired toxic effects [43]. In contrast, the untargeted distribution of SLN/ICG caused systematic toxicity to mice which was reflected by the time-dependent decrease in body weight.…”

Section: In Vivo Study Of the Antitumour Abilitymentioning

confidence: 88%

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Photothermal therapy (PTT) is a rapidly developing approach for cancer therapy, which has been widely recognized to exert high efficacy as compared to chemotherapy. However, the limited tumour homing property of currently available drug delivery systems (DDSs) is the bottleneck for the efficient delivery of photothermal agents. Here in this study, we surface modified silica nanoparticles (SLN) with the cell membrane (CM) derived from 143B cells to construct a platform (CM/SLN) capable of targeting the homogenous 143B cells. In addition, indocyanine green (ICG) as a photothermal agent was encapsulated into CM/SLN to finally construct a DDS suitable for tumour-targeted PTT of osteosarcoma. Our results revealed that CM/SLN/ICG was mono-dispersed core-shell nanoparticles with advanced stability in a physiological environment. Moreover, due to the modification of CM, CM/SLN/ICG could specifically target the homogenous 143B cells both in vitro and in vivo, which demonstrated superior anticancer efficacy when compared with either SLN/ICG or free ICG. Hence, CM/SLN/ICG could be a promising DDS for tumour targeted PTT of osteosarcoma.

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Section: In Vivo Study Of the Antitumour Abilitymentioning

confidence: 88%

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…These results were consistent with the previous report that positively-charged DDSs can preferably be captured by the liver, while negatively-charged ones can reduce this dilemma. 23 These results indicated that LDL/SLN/Adr had stronger tumor-targeting ability than ASLN/Adr and that it showed preferable accumulation at the tumor tissue. They showed that LDL/SLN/Adr can act as a safe and effective DDS that delivers its payload to the targeted cells and achieves better anticancer effect.…”

Section: Discussionmentioning

confidence: 78%

“…The negatively-charged surface, according to the previous report, might be beneficial for the ability of the DDSs to bypass the recognition of many active components within the circulation system, and might ensure safe delivery of the drugs. 23 Due to their large surface area and pore volume, SLNs were capable of loading a variety of drugs, ranging from hydrophobic ones to hydrophilic ones, with a relatively high loading efficiency. This is beneficial for SLNs to act as a co-delivery carrier for the loading of Adr.…”

Section: Discussionmentioning

confidence: 99%

Low-density lipoprotein-decorated and Adriamycin-loaded silica nanoparticles for tumor-targeted chemotherapy of colorectal cancer

Shi¹,

Li²,

Yan³

et al. 2018

Adv Clin Exp Med

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Background. Chemotherapy for colorectal cancer remains an unsatisfactory method of treatment and requires the development of more advanced drug delivery systems (DDSs). Among inorganic materials, silica nanoparticles (SLNs) have been considered a suitable candidate to be developed as versatile carriers for drug delivery and imaging applications. Low-density lipoprotein (LDL) is a widespread material that is responsible for cholesterol transport in plasma. The concept of employing LDL-modified nanoparticles for tumor-targeted drug delivery has been widely adopted. Objectives. The objective of this study was to develop and test a new DDS for effective chemotherapy of colorectal cancer. Material and methods. We successfully developed an Adriamycin (Adr)-loaded DDS based on LDL-modified SLNs (LDL/SLN/Adr). The tumor-homing property of LDL and the drug-loading capability of SLNs were combined to prepare LDL/SLN/Adr that can specifically deliver Adr to the cancer site to achieve effective chemotherapy of HT-29 colorectal cancer. Results. In vitro analysis showed that LDL/SLN/Adr consisted of nano-sized particles and was capable of targeting the low-density lipoprotein receptors (LDLR) which were overexpressed in many cancer cell lines. As a result, LDL/SLN/Adr exerted better cytotoxicity than unmodified SLNs and free drugs. In vivo imaging and anticancer assays also confirmed the preferable tumor-homing and enhanced anticancer effect of LDL/SLN/Adr. Conclusions. LDL/SLN/Adr might be a promising DDS for effective chemotherapy of colorectal cancer.

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“…It is well recognized that nanoparticles with negative surface charge could be more favorable than their positively charged counterparts in circulation, since the majority of plasma proteins in the blood stream are negatively charged. 29 As a result, upon being introduced into the circulation, the positively charged nanoparticles would be recognized and retarded by the abundant plasma proteins due to electrostatic interaction between reverse-charged particles, which could have disappointing results due to the fact that these nanoparticles cannot travel far or long enough to satisfy the minimal requirement of drug delivery. 31 In our study, the components of the as-prepared nanoparticles were mostly negatively charged lipids that finally resulted in the formation of negatively charged-NLC.…”

Section: Results and Discussion Characterization Of Nanoparticlesmentioning

confidence: 99%

“…The in vivo tumor targeting efficacy and biodistribution of DiR-loaded LDNLC was evaluated using In Vivo Imaging System (FXPRO; Kodak, NY, USA) equipped with DiR filter sets (excitation/emission, 720/790 nm). 29 The in vivo plasma pharmacokinetic and DOX biodistribution studies were performed according to a previous report. 15 In brief, female BALB/c nude mice were randomly divided into two groups (n = 3), and intravenously injected with free DOX or LDNLC (DOX dosage: 5 mg/kg).…”

Section: In Vivo Distributionmentioning

confidence: 99%

Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy

Li¹,

Jia²,

Hu³

2018

IJN

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BackgroundMultidrug resistance is responsible for the poor outcome in breast cancer therapy. Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P) H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-delivered DOX to overcome MDR in cancer cells.PurposeHerein, in our study, nanostructured lipid carrier (NLC) co-delivering β-lapachone (Lapa) and doxorubicin (DOX) was developed (LDNLC) with the aim to overcome the multidrug resistance (MDR) in breast cancer therapy.Patients and methodsLapa and DOX were loaded into NLC to prepare LDNLC using melted ultrasonic dispersion method.ResultsThe well designed LDNLC was nanoscaled particles that exhibited preferable stability in physiological environment. In vitro cell experiments on MCF-7 ADR cells showed increased DOX retention as compared to DOX mono-delivery NLC (DNLC). In vivo anti-cancer assays on MCF-7 ADR tumor bearing mice model also revealed significantly enhanced efficacy of LDNLC than mono-delivery NLCs (DNLC and LNLC).ConclusionLDNLC might be a promising platform for effective breast cancer therapy.

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Retraction: A multifunctional self-dissociative polyethyleneimine derivative coating polymer for enhancing the gene transfection efficiency of DNA/polyethyleneimine polyplexes in vitro and in vivo

Abstract: Retraction of ‘A multifunctional self-dissociative polyethyleneimine derivative coating polymer for enhancing the gene transfection efficiency of DNA/polyethyleneimine polyplexes in vitro and in vivo’ by Cheng Wang, et al., Polym. Chem., 2015, 6, 780–796.

Cited by 16 publications

References 0 publications

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

Low-density lipoprotein-decorated and Adriamycin-loaded silica nanoparticles for tumor-targeted chemotherapy of colorectal cancer

Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy

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