Retraction

Fan, Youqiang; Hao, Jingduo; Cen, Xueying; Song, Kun; Yang, Chunbo; Xiao, Shengwen; Cheng, Shuying

doi:10.1002/ddr.21876

Drug Development Research

2021

DOI: 10.1002/ddr.21876

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Retraction

Youqiang Fan¹,

Jingduo Hao²,

Xueying Cen³

et al.

Abstract: Retraction: ‘Downregulation of miR‐487a‐3p suppresses the progression of non‐small cell lung cancer via targeting Smad7’ by Fan Y, Hao J, Cen X, Song K, Yang C, Xiao S, Cheng S, Drug Development Research. 2021. https://doi.org/10.1002/ddr.21876. The above article, published online on 15 September 2021 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Steven Fletcher, and Wiley Periodicals, LLC. The retraction has been agre… Show more

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MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

Valacchi

Pambianchi

Coco

et al. 2022

JPM

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Epigenetic alterations are a driving force of the carcinogenesis process. MicroRNAs play a role in silencing mutated oncogenes, thus defending the cell against the adverse consequences of genotoxic damages induced by environmental pollutants. These processes have been well investigated in lungs; however, although skin is directly exposed to a great variety of environmental pollutants, more research is needed to better understand the effect on cutaneous tissue. Therefore, we investigated microRNA alteration in human skin biopsies exposed to diesel fumes, ozone, and UV light for over 24 h of exposure. UV and ozone-induced microRNA alteration right after exposure, while the peak of their deregulations induced by diesel fumes was reached only at the end of the 24 h. Diesel fumes mainly altered microRNAs involved in the carcinogenesis process, ozone in apoptosis, and UV in DNA repair. Accordingly, each tested pollutant induced a specific pattern of microRNA alteration in skin related to the intrinsic mechanisms activated by the specific pollutant. These alterations, over a short time basis, reflect adaptive events aimed at defending the tissue against damages. Conversely, whenever environmental exposure lasts for a long time, the irreversible alteration of the microRNA machinery results in epigenetic damage contributing to the pathogenesis of inflammation, dysplasia, and cancer induced by environmental pollutants.

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MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

Valacchi

Pambianchi

Coco

et al. 2022

JPM

View full text Add to dashboard Cite

show abstract

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Retraction

Cited by 1 publication

References 24 publications

MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

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