RETRACTED: Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study

Jungebluth, Philipp; Alici, Evren; Baiguera, Silvia; Blomberg, Pontus; Bozóky, Béla; Crowley, Claire; Einarsson, Óskar; Guðbjartsson, Tómas; Guyader, Sylvie Le; Henriksson, Gert; Hermanson, Ola; Juto, Jan Erik; Leidner, Bertil; Lilja, Tobias; Líška, Ján; Luedde, Tom; Lundin, Vanessa; Moll, Guido; Roderburg, Christoph; Strömblad, Staffan; Sütlü, Tolga; Watz, Emma; Seifalian, Alexander M.; Macchiarini, Paolo

doi:10.1016/s0140-6736(11)61715-7

Cited by 394 publications

(310 citation statements)

References 26 publications

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“…Paolo Macchiarini from the Hospital Clinic de Barcelona then gave a presentation entitled "Cell Therapy and Bioengineered Replacement of the Airways," in which he discussed the evidence showing that stem cells can be successfully applied to airway transplants for adults and children (37,38). He then VERMONT STEM CELL CONFERENCE extrapolated this to the vision that stem cell therapy might be extended to treat untreatable end-stage lung diseases.…”

Section: Session 2: Embryonic Stem Cells Ipscs and Lung Regenerationmentioning

confidence: 99%

Stem Cells and Cell Therapies in Lung Biology and Diseases: Conference Report

Weiss¹,

Bates²,

Gilbert³

et al. 2013

Annals ATS

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Section: Session 2: Embryonic Stem Cells Ipscs and Lung Regenerationmentioning

confidence: 99%

Stem Cells and Cell Therapies in Lung Biology and Diseases: Conference Report

Weiss¹,

Bates²,

Gilbert³

et al. 2013

Annals ATS

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“…A lthough replacement of airways (1)(2)(3)(4)(5)(6) or urogenital tissue (7) using stem cell-based techniques has been achieved, engineering of functional contractile muscle tissue has only been partially explored (8)(9). While debates have been generated around which myogenic progenitors (satellite cells, muscle stem cells, or myoblasts) should be used, fewer studies have focused on exploring which matrix could offer a better platform for regeneration (10,11).…”

mentioning

confidence: 99%

Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model

Fishman

Lowdell

Urbani³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

181

137

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Decellularized (acellular) scaffolds, composed of natural extracellular matrix, form the basis of an emerging generation of tissueengineered organ and tissue replacements capable of transforming healthcare. Prime requirements for allogeneic, or xenogeneic, decellularized scaffolds are biocompatibility and absence of rejection. The humoral immune response to decellularized scaffolds has been well documented, but there is a lack of data on the cellmediated immune response toward them in vitro and in vivo. Skeletal muscle scaffolds were decellularized, characterized in vitro, and xenotransplanted. The cellular immune response toward scaffolds was evaluated by immunohistochemistry and quantified stereologically. T-cell proliferation and cytokines, as assessed by flow cytometry using carboxy-fluorescein diacetate succinimidyl ester dye and cytometric bead array, formed an in vitro surrogate marker and correlate of the in vivo host immune response toward the scaffold. Decellularized scaffolds were free of major histocompatibility complex class I and II antigens and were found to exert anti-inflammatory and immunosuppressive effects, as evidenced by delayed biodegradation time in vivo; reduced sensitized T-cell proliferative activity in vitro; reduced IL-2, IFN-γ, and raised IL-10 levels in cell-culture supernatants; polarization of the macrophage response in vivo toward an M2 phenotype; and improved survival of donor-derived xenogeneic cells at 2 and 4 wk in vivo. Decellularized scaffolds polarize host responses away from a classical TH1-proinflammatory profile and appear to down-regulate T-cell xeno responses and TH1 effector function by inducing a state of peripheral T-cell hyporesponsiveness. These results have substantial implications for the future clinical application of tissue-engineered therapies.

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“…It was used as a synthetic 3D scaffold, and it was functionalized in a bioreactor with stem cells extracted from the bone marrow as shown in Figure 1. This first successful tissueengineered trachea, implanted in the patient as a compassionate case, showed that with the use of synthetic biocompatible nanomaterials, stem cells organ development in a laboratory is now a real possibility for terminally ill patients with failing organs [14].…”

Section: Development Of Organs Using Stem Cellsmentioning

confidence: 99%

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RETRACTED: Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study

Cited by 394 publications

References 26 publications

Stem Cells and Cell Therapies in Lung Biology and Diseases: Conference Report

Stem Cells and Cell Therapies in Lung Biology and Diseases: Conference Report

Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model

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