RETRACTED: The effect of 2′,4′,7‐trihydroxyisoflavone on ultraviolet‐induced matrix metalloproteinases‐1 expression in human skin fibroblasts

Moon, Hyung-In; Chung, Jin Ho

doi:10.1016/j.febslet.2005.12.094

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Based on these previous observations and our current findings, it is strongly suggested that PQQ contributes to the stimulation of DNA synthesis in cell proliferation via simultaneous phosphorylation of ERK and PKC-ε, followed by degradation of p27 and phosphorylation of Rb. The downstream effectors of the MAPKs include several transcription factors, such as c-Jun, c-Fos and Elk-1 (38,42). The activation of the MAPK cascade is succeeded by an increase in the expression of c-Jun and c-Fos, which form the AP-1 complex.…”

Section: Discussionmentioning

confidence: 99%

Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts

Kumazawa¹,

Hiwasa²,

Takao³

et al. 2007

Int J Mol Med

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Abstract. Pyrroloquinoline quinone (PQQ) has been implicated in certain physiological activities in mammals such as functioning as a potent growth factor in mice, and promoting DNA synthesis in human fibroblasts. These are clearly important physiological functions, however, the molecular mechanisms involved in PQQ activity are not yet fully understood. In order to address this, in this study we analyzed the effects of PQQ on the proliferation of NIH3T3 mouse fibroblasts and on their intracellular signal transduction mechanism. When activated c-Ha-ras-transformed NIH3T3 cells were treated with PQQ in the presence of 0.5% calf serum in DMEM, the cells showed significantly increased viability. After PQQ addition, flow cytometric analysis revealed a decrease in the population of cells in the G 0 /G 1 phase and a concomitant increase in cells in the S and G 2 /M phases. Although treatment with SNAP, an NO donor, reduced cell viability, this effect was abolished by the addition of PQQ. Activation of ERK and PKC-ε was detected immediately after the addition of PQQ, and subsequent increases in the phosphorylation of Rb and c-Jun were observed. On the other hand, protein expression levels of growth-inhibitory molecules such as IκB and p27 decreased after PQQ treatment. These results suggest that PQQ stimulates cell proliferation through NO-sensitive Rasmediated signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts

Kumazawa¹,

Hiwasa²,

Takao³

et al. 2007

Int J Mol Med

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“…Reason: This article has been retracted at the request of the editors and authors due to unreliable data resulting from instrument error [83].…”

mentioning

confidence: 99%

“…Similarly, there was no salutation/sign-off or other disambiguating information that could help to determine whether the second RN [83] was authored by the journal authorities alone or jointly by the authors of the retracted article and the journal authorities. Although journal authorities are likely to reference the publishers' policy on retraction to justify their decisions to retract published articles, authors of retracted articles do occasionally refer to such policy, as illustrated by the example below.…”

mentioning

confidence: 99%

Retraction Notices: Who Authored Them?

2018

Publications

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Unlike other academic publications whose authorship is eagerly claimed, the provenance of retraction notices (RNs) is often obscured presumably because the retraction of published research is associated with undesirable behavior and consequently carries negative consequences for the individuals involved. The ambiguity of authorship, however, has serious ethical ramifications and creates methodological problems for research on RNs that requires clear authorship attribution. This article reports a study conducted to identify RN textual features that can be used to disambiguate obscured authorship, ascertain the extent of authorship evasion in RNs from two disciplinary clusters, and determine if the disciplines varied in the distributions of different types of RN authorship. Drawing on a corpus of 370 RNs archived in the Web of Science for the hard discipline of Cell Biology and the soft disciplines of Business, Finance, and Management, this study has identified 25 types of textual markers that can be used to disambiguate authorship, and revealed that only 25.68% of the RNs could be unambiguously attributed to authors of the retracted articles alone or jointly and that authorship could not be determined for 28.92% of the RNs. Furthermore, the study has found marked disciplinary differences in the different categories of RN authorship. These results point to the need for more explicit editorial requirements about RN authorship and their strict enforcement.

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“…Genistein was seen to inhibit photo‐product formation in human reconstituted skin (92), while in hairless mouse it even affects tumor incidence and multiplicity (93). Furthermore, this compound diminishes UV‐induced induction of matrix metalloproteinase‐1, which play part in the pathogenesis of photoaging and it inhibits production of certain inflammatory cytokines (94). Nobilitin, investigated as photo‐protectant by virtue of its anti‐carcinogenic properties, prevents photoinflammation and also photoaging partially by influencing UV‐induced COX‐2 expression.…”

Section: Exite Endogenous Responsementioning

confidence: 99%

New Strategies of Photoprotection

Verschooten

Claerhout

Laethem

et al. 2006

Photochem & Photobiology

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Adequate photoprotection is essential to control UV-related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming that they are used properly. However, new strategies, which are based on or make use of the endogenous protective response to UV light, may further improve currently used photoprotective means. The addition of repair enzymes and/or antioxidants has a positive effect on skin's recovery from UV-induced DNA-damage. Several botanical agents, mainly vitamins and polyphenols, have shown to influence signal transduction pathways leading to photoprotective effects. Also stimulation of endogenous UV-response pathways via irradiation with a low UV dose or via simulation of UV-induced DNA-damage results in photoprotective effects. Future research in this field and combination of different photoprotective strategies will hopefully lead to improved photoprotection.

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RETRACTED: The effect of 2′,4′,7‐trihydroxyisoflavone on ultraviolet‐induced matrix metalloproteinases‐1 expression in human skin fibroblasts

Cited by 7 publications

References 20 publications

Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts

Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts

Retraction Notices: Who Authored Them?

New Strategies of Photoprotection

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