RETRACTED: Taguchi-Assisted Optimization Technique and Density Functional Theory for Green Synthesis of a Novel Cu-MOF Derived From Caffeic Acid and Its Anticancerious Activities

Abstract

In this paper, we have reported an innovative greener method for developing copper-metal organic frameworks (Cu-MOFs) using caffeic acid (CA) as a linker extracted from Satureja hortensis using ultrasonic bath. The density functional theory is used to discuss the Cu-MOF-binding reaction mechanism. In order to achieve a discrepancy between the energy levels of the interactive precursor orbitals, the molecules have been optimized using the B3LYP/6–31G method. The Taguchi method was used to optimize the key parameters for the synthesis of Cu-MOF. FT-IR, XRD, nitrogen adsorption, and SEM analyses are used to characterize it. The adsorption/desorption and SEM analyses suggested that Cu-MOF has a larger surface area of 284.94 m2/g with high porosity. Cu-MOF has shown anticancer activities against the human breast cancer (MDA-MB-468) cell lines, and it could be a potent candidate for clinical applications.

Lignin and metal–organic frameworks: mutual partners on the road to sustainability

“…It is expected to be a promising anti-cancer drug due to its good biocompatibility and anti-cancer activity exhibited against human breast cancer cells. 61 Simultaneously, the cytotoxicity test also confirmed the biosafety of these bio-MOFs. 55…”

“…It is expected to be a promising anti-cancer drug due to its good biocompatibility and anti-cancer activity exhibited against human breast cancer cells. 61 Simultaneously, the cytotoxicity test also conrmed the biosafety of these bio-MOFs. 55 In addition to biomedicine, bio-MOFs are already shining in the elds of food safety, energy storage, catalysis, environmental pollution, etc.…”

“…5c). 61 Cu-MOF–CA was uniformly distributed with a particle size of less than 100 nm and had a spherical or octahedral morphology. 61 Pan et al prepared core–shell OV–BiVO 4 @NiFe-MOFs by encapsulating NiFe-MOFs on oxygen-rich vacancy BiVO 4 (OV–BiVO 4 ) using CA as a bridging agent (Fig.…”

Copper(ii)-MOFs for bio-applications

“…1,17,18 Therefore, from performing solvothermal syntheses that are typically carried out in DMF and high temperatures, 19 to green syntheses carried out in aqueous or methanolic media at room temperature, together with the aforementioned characteristics, allow the control of the morphology and size of the crystals. 20,21 However, currently, alternative methods such as microwaveassisted, sonochemical, mechanochemical, and microfluidic synthesis have been adopted, and these techniques have been mainly proposed to improve the yield and reduce costs of syntheses, as well as achieve scalability as there are only a few processes reported for use at an industrial level. 22,23 The main methods used for the synthesis of copper are in solution and in the solid phase.…”

“…22,23 The main methods used for the synthesis of copper are in solution and in the solid phase. The first method involves the dissolution of the metallic and organic precursors in a common solvent, which allows the formation of copper-based MOFs in a solution, 21 while in the second method the reaction of metallic and organic precursors is carried out in an environment of high temperature and pressure, which allows the formation of MOFs. 24 However, the most classical method is the synthesis by chemical vapor deposition, which consists of the deposition of the metallic and organic precursors being carried out on a solid substrate through evaporation and condensation in the vapor phase.…”