RETRACTED: Surface PEGylation of ZIF-8 metal-organic framework based on magnetic hydroxyapatite as a pH/magnetic targeting responsive system for anticancer drug delivery

Zeyni, Vahid; Karimi, Soheyla; Namazi, Hassan

doi:10.1016/j.micromeso.2023.112544

Cited by 20 publications

(5 citation statements)

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“…Different magnetic biomaterials are used as drug delivery systems, in particular [ 273 ], magnetic hydroxyapatite [ 282 ], magnetic nanocomposite [ 283 ], magnetic microspheres [ 284 ], and magnetically responsive hydrogels [ 285 ]. These materials allow for targeted and controlled drug release to the targeted cells (like cancerous cells) by external magnetic fields ( Figure 7 ), hence improving the therapeutic effect and reducing side effects.…”

Section: Magnetic Hydroxyapatite Nanoparticles In Nanomedicinementioning

confidence: 99%

“…In the treatment of cancer diseases, it has been reported that doxorubicin encapsulation efficiency may exceed 90% in the mesoporous structure of metal–polyphenol network coated magnetic hydroxyapatite nanoparticles with excellent dispersion, high specific surface area, and large pore size [ 293 ]. The desirable properties for drug loading and drug encapsulation efficiency was exhibited by magnetic hydroxyapatite nanocomposites (Fe 3 O 4 @SiO 2 @HA@ZIF-8-PEG) due to their substantial surface area [ 282 ]. Iron-doped superparamagnetic apatite (FeHA) NPs were reported to have a better affinity for the anticancer drug doxorubicin (DOX) than iron-free biomimetic HA NPs, primarily due to the strong affinity of drug for the iron cations of the FeHA surface.…”

Section: Magnetic Hydroxyapatite Nanoparticles In Nanomedicinementioning

confidence: 99%

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Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest over the last few years for their great potential, offering advanced multi-therapeutic strategies because of their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The most relevant synthetic methods to obtain magnetic apatite-based materials, either in the form of iron-doped HA nanoparticles showing intrinsic magnetic properties or composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles, are described as highlighting structure–property correlations. Following this, this review discusses the application of various magnetic hydroxyapatite nanomaterials in bone regeneration and nanomedicine. Finally, novel perspectives are investigated with respect to the ability of mHA nanoparticles to improve nanocarriers with homogeneous structures to promote multifunctional biological applications, such as cell stimulation and instruction, antimicrobial activity, and drug release with on-demand triggering.

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Section: Magnetic Hydroxyapatite Nanoparticles In Nanomedicinementioning

confidence: 99%

Section: Magnetic Hydroxyapatite Nanoparticles In Nanomedicinementioning

confidence: 99%

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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“…It is worth noting that except high load bearing capacity, ZIF-8 is capable of breaking down in acid and weak-acid environmental pH [38,39]. This characteristic of zinc imidazolate makes it promising for targeted drug delivery [40][41][42][43][44][45]. Some researchers have described the modifications of MOF-based composites by specific components, which ease its binding with targeted cell receptors, it additionally strengthening the potential of these carriers as the means of targeted drug delivery [35,46].…”

Section: Introductionmentioning

confidence: 99%

Biomineralization of Human Genomic DNA into ZIF-8, a Zeolite-Like Metal-Organic Framework

Shaykhutdinov,

Iliasov,

Limareva

et al. 2024

Sovrem Tehnol Med

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The aim of the study was to assess the capabilities of human genomic DNA biomineralization into ZIF-8 metal-organic framework (MOF) preserving DNA sequence integrity after the encapsulation cycle and composite dissolving. The study is an initial stage of the project aimed at developing an abiotic vector to be used when working with native nucleic acids of an arbitrary size based on DNA@ZIF-8 composite.Materials and Methods. We studied human genomic DNA isolated from lymphocytes of peripheral blood of healthy volunteers using Proba-NK kit (DNA-Technology LLC, Russia). Genomic DNA purity and concentration was estimated spectrophotometrically at 260/280 nm using Tecan Infinity 200 Pro plate reader (Tecan Instruments, Austria). ZIF-8 was synthesized in the physiological conditions (37°C) by mixing zinc salt and 2-methylimidazole aqueous solutions at different molar ratios. Human genomic DNA was encapsulated into ZIF-8 in similar conditions. The obtained MOF and DNA@ZIF-8 composite were studied using X-ray powder diffraction at the Phaser D2 XRPD device (Bruker, USA), and the specific surface area was estimated using Autosorb iQ porosimetry analyzer (Quantachrome, USA). The encapsulated DNA was quantified by dissolving DNA@ZIF-8 composite in the citrate buffer. DNA integrity was assessed by real-time allele-specific PCR (AS-PCR) using the kits for single nucleotide polymorphisms (Lytech, Russia) at the Quantstudio 6 Pro PCR machine (Thermo Scientific, USA). In case of using the kits with electrophoretic detection, the amplification was performed on the thermal cycler T100 (Thermo Scientific, USA).Results. The polymer ZIF-8 and DNA@ZIF-8 composite were obtained at different molar ratios of zinc ions and 2-methylimidazole. We characterized their structure and specific surface area. Genomic DNA biomineralization efficacy was found to be about 7-8%. PCR indicated the integrity of non-selectively chosen loci within the biomineralized DNA.Conclusion. The study confirmed the possibility of human genomic DNA encapsulation into ZIF-8 metal-organic framework. After the biomineralization, DNA was found to preserve feasibility to be used in studies to investigate genetic constructs.

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“…Hence, the development of nontoxic, biocompatible drug carriers is a great challenge for the sustainable drug delivery process. , In this context, zeolitic imidazolate frameworks (ZIFs) are considered as the most nontoxic and biocompatible metal organic frameworks along with high thermal and chemical stability, well-defined pores, and a high specific surface area . Moreover, for drug delivery, the zeolitic imidazolate frameworks are more advantageous over other metal organic frameworks, as they can fabricate pH-responsive drug delivery systems . ZIF-8, the most representative zeolitic imidazolate framework, has a sodalite zeolite-type topology consisting of Zn 2+ ions as secondary building units and 2-methylimidazole as a linker .…”

Section: Introductionmentioning

confidence: 99%

“… 15 Moreover, for drug delivery, the zeolitic imidazolate frameworks are more advantageous over other metal organic frameworks, as they can fabricate pH-responsive drug delivery systems. 16 ZIF-8, the most representative zeolitic imidazolate framework, has a sodalite zeolite-type topology consisting of Zn 2+ ions as secondary building units and 2-methylimidazole as a linker. 17 Recently, ZIF-8 and its composites with other functional materials have been extensively used in various biomedical applications, especially in the drug delivery process, because of their dissolution in acidic or neutral media.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe₃O₄ NPs Nanocarrier

Chakraborty,

Nandi,

Kumar

et al. 2024

ACS Omega

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In this work, a one-pot multicomponent synthesis of the ibuprofen-loaded Fe 3 O 4 nanoparticles-supported zeolitic imidazolate framework-8 (Ibu-ZIF-8/Fe 3 O 4 NPs) nanohybrid was carried out. The ZIF-8/Fe 3 O 4 NPs nanohybrid was used as a drug carrier for the in vitro release of ibuprofen in a PBS solution. The structure and morphology of the synthesized materials were investigated by powder X-ray diffraction (PXRD) analysis, transmission electron microscopy (TEM) analysis, UV−visible absorption studies, FTIR spectroscopy, and thermogravimetric analysis (TGA). The ibuprofen release kinetics was studied by UV−visible spectroscopy. The mechanism of drug delivery was thoroughly investigated and the Higuchi model was found as the best-fitted model for the ibuprofen release study. The 20 wt % Fe 3 O 4 NPs-supported ZIF-8 nanohybrid exhibited more than 95% ibuprofen release efficiency in phosphate buffer saline of pH 7.4 within 2 h. The separation ability of the nanohybrid was very good, and it was easily separated by a simple commercial magnet. In order to investigate the cell viability, the cytotoxicity of ZIF-8, Fe 3 O 4 NPs, and ZIF-8/20 wt % Fe 3 O 4 NPs was investigated using MTT assays against Leishmania donovani promastigotes. The ZIF-8/20 wt % Fe 3 O 4 NPs nanohybrid carrier exhibited a cell growth inhibition effect with a high correlation coefficient and low probability (p) values. The high release of drug molecules may be due to the more open site of the ZIF-8/Fe 3 O 4 NPs nanohybrid. The drug release profile suggests that the nanohybrid can be potentially used as a drug carrier for targeted drug delivery systems.

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RETRACTED: Surface PEGylation of ZIF-8 metal-organic framework based on magnetic hydroxyapatite as a pH/magnetic targeting responsive system for anticancer drug delivery

Cited by 20 publications

References 53 publications

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Biomineralization of Human Genomic DNA into ZIF-8, a Zeolite-Like Metal-Organic Framework

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe₃O₄ NPs Nanocarrier

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RETRACTED: Surface PEGylation of ZIF-8 metal-organic framework based on magnetic hydroxyapatite as a pH/magnetic targeting responsive system for anticancer drug delivery

Cited by 20 publications

References 53 publications

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Biomineralization of Human Genomic DNA into ZIF-8, a Zeolite-Like Metal-Organic Framework

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier

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Resources

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Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe₃O₄ NPs Nanocarrier