RETRACTED: Revamping of Chronic Respiratory Diseases in Low- and Middle-Income Countries

Zeng, Ling‐Hui; Hussain, Musaddique; Syed, Shahzada Khurram; Saadullah, Malik; Jamil, Qurratulain; Alqahtani, Ali; Alqahtani, Taha; Akram, Nadia; Khan, Imran; Parveen, Sajida; Fayyaz, Tehreem; Fatima, Mobeen; Shaukat, Saira; Shabbir, Najia; Fatima, Mehwish; Kanwal, Aisha; Barkat, Muhammad Qasim; Wu, Ximei

doi:10.3389/fpubh.2021.757089

Cited by 5 publications

(6 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The situation is even more dramatic in low and middle-income countries, where 80% of COPD cases get undiagnosed in clinical care. 50 WHO Noncommunicable Disease Global Action Plan addressed the necessity for diagnostic tools for noncommunicable diseases that were affordable, reliable, and safe and showed improved disease diagnostic capacity and human resources. 51 In 2003, WHO coined the well-known ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and ready to be delivered) that a diagnostic tool in the developing world should fulfill to guide disease management effectively.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The deployed implementation of compact analytical platforms that enabled the quantitative simultaneous detection of several biomarkers could have a huge impact on effective disease management by improving the underdiagnosis and misdiagnosis rates and in turn alleviating the economic burden on the healthcare systems. The situation is even more dramatic in low and middle-income countries, where 80% of COPD cases get undiagnosed in clinical care …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Engineering a Point-of-Care Paper-Microfluidic Electrochemical Device Applied to the Multiplexed Quantitative Detection of Biomarkers in Sputum

et al. 2023

View full text Add to dashboard Cite

Health initiatives worldwide demand affordable point-of-care devices to aid in the reduction of morbidity and mortality rates of high-incidence infectious and noncommunicable diseases. However, the production of robust and reliable easy-to-use diagnostic platforms showing the ability to quantitatively measure several biomarkers in physiological fluids and that could in turn be decentralized to reach any relevant environment remains a challenge. Here, we show the particular combination of paper-microfluidic technology, electrochemical transduction, and magnetic nanoparticle-based immunoassay approaches to produce a unique, compact, and easily deployable multiplex device to simultaneously measure interleukin-8, tumor necrosis factor-α, and myeloperoxidase biomarkers in sputum, developed with the aim of facilitating the timely detection of acute exacerbations of chronic obstructive pulmonary disease. The device incorporates an on-chip electrochemical cell array and a multichannel paper component, engineered to be easily aligned into a polymeric cartridge and exchanged if necessary. Calibration curves at clinically relevant biomarker concentration ranges are produced in buffer and artificial sputum. The analysis of sputum samples of healthy individuals and acutely exacerbated patients produces statistically significant biomarker concentration differences between the two studied groups. The device can be mass-produced at a low cost, being an easily adaptable platform for measuring other disease-related target biomarkers.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Engineering a Point-of-Care Paper-Microfluidic Electrochemical Device Applied to the Multiplexed Quantitative Detection of Biomarkers in Sputum

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Mortality distribution was highest for LMIC in the African continent, while Philippines, Maldives and Thailand were among the leading in APR. A recent review on chronic respiratory diseases found a staggering 96% of asthma‐related deaths and 84% of disability‐adjusted life years (DALY) worldwide in LMICs 17 …”

Section: Asthma Prevalence and Disease Burdenmentioning

confidence: 99%

“…A recent review on chronic respiratory diseases found a staggering 96% of asthmarelated deaths and 84% of disability-adjusted life years (DALY) worldwide in LMICs. 17 A Lancet review on asthma in LMICs has shown that although asthma ranked as the 28th most common cause of disability-adjusted years of life lost (YLL) worldwide in 2015, it was the 8th highest cause of YLL in Oceania (Fiji, Kiribati, Marshall Islands, Micronesia, Papua New Guinea, Samoa, Solomon Islands, Tonga, Vanuatu). 8 The review also found that many adult asthmatics are only identified in emergency rooms and there is lack of proper follow-up and treatment.…”

Section: Burdenmentioning

confidence: 99%

Asthma in developing countries in the Asia‐Pacific Region (APR)

Yasaratne,

Idrose,

Dharmage

2023

Respirology

View full text Add to dashboard Cite

There is growing interest in the epidemiology of asthma in developing countries, especially in the Asia‐Pacific Region (APR). A number of reviews have been published in this field, but a comprehensive synthesis of overall data has not been reported. Here, we summarized the burden, risk factors and challenges of asthma management in developing countries with a specific emphasis on the APR by consolidating evidence from both systematic and narrative reviews published up until February 2023. We found that although asthma prevalence in low and low‐middle‐income countries (LMICs) is known to be generally lower compared to high‐income countries, the burden is substantially greater. Studies conducted in APR LMIC have reported a range of risk factors, including pre‐ and post‐natal factors, environmental considerations, lifestyle measures, individual features and genetics. The low and inequitable distribution of quality preventive and curative health care, a lack of advanced diagnostic measures, non‐availability and non‐affordability of novel therapeutics, cultural beliefs and practices, and diverse disease phenotypes make it challenging to achieve optimal asthma control in the region. Hence, we call for the development of a region‐specific blueprint for action to mitigate this challenging situation, to help reduce the burden of asthma in APR LMIC.

show abstract

“…Exposure to biomass fuel smoke, ambient air pollution, and smoking are the key risk factors of CRDs 3 . The burden of CRDs is disproportionately high in low‐ and middle‐income countries (LMICs), considering the ampler presence of risk factors, lack of knowledge and awareness of the disease, and its risk factors at the population level, which is further challenged by the lack of health system capacity to prevent and manage the rising burden of CRDs 4 . Most CRD‐related deaths occur in Asian countries, with approximately 75% of all cases 2 .…”

Section: Introductionmentioning

confidence: 99%

Burden and risk factors of chronic respiratory diseases in Nepal, 1990–2019: An analysis of the global burden of diseases study

Adhikari

Paudel

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

Background and Aims Chronic respiratory diseases (CRDs) substantially contribute to morbidity and mortality globally and in Nepal. However, there is a paucity of evidence on the trend and the burden of CRDs in Nepal. This study reports the trend of the burden and contribution of major risk factors to CRDs in Nepal from 1990 to 2019. Methods This study is an observational study using publicly available data from Global Burden of Disease 2019 estimations for Nepal. The age‐standardized and age‐specific prevalence, incidence, mortality, disability‐adjusted life years (DALYs), and risk factors for CRDs in Nepal were extracted to measure the burden and its trend. The data are presented as percentages or as rates per 100,000 population. Results The age‐standardized incidence rate of CRDs in Nepal in 2019 was 913.6 per 100,000 (95% uncertainty interval [UI]: 828.7–1000.1), which was an increase of 7.7% from 848.6 per 100,000 (95% UI: 780.2–918.2) in 1990. However, the age‐standardized prevalence rate [4453/100,000 (4234.2–4671.8) in 1990; 4457.1/100,000 (4255.2–4666.8) in 2019] was almost stagnant. Most CRDs attributed to deaths and DALYs were due to chronic obstructive pulmonary disease. Conclusions Air pollution and smoking are the main risk factors for DALYs due to CRDs in Nepal. This surging burden of the incidence rate of CRDs in Nepal calls for more effective actions to curb the risk factors and diseases.

show abstract

RETRACTED: Revamping of Chronic Respiratory Diseases in Low- and Middle-Income Countries

Cited by 5 publications

References 139 publications

Engineering a Point-of-Care Paper-Microfluidic Electrochemical Device Applied to the Multiplexed Quantitative Detection of Biomarkers in Sputum

Engineering a Point-of-Care Paper-Microfluidic Electrochemical Device Applied to the Multiplexed Quantitative Detection of Biomarkers in Sputum

Asthma in developing countries in the Asia‐Pacific Region (APR)

Burden and risk factors of chronic respiratory diseases in Nepal, 1990–2019: An analysis of the global burden of diseases study

Contact Info

Product

Resources

About