[Retracted] Prevalence, Mechanisms, Treatment, and Complications of Hypertension Postliving Kidney Donation

Abstract

Living kidney donors represent a unique population of patients. Potential donors are selected based on the belief that their preoperative fitness is likely to mitigate the risks of long- and short-term harm following uninephrectomy. Studies performed on postdonation outcomes have largely focused on mortality and the risk of end-stage renal failure, but have also investigated secondary outcomes such as cardiovascular morbidity and hypertension. It has been postulated that hypertension is a possible outcome of living kidney donation. A variety of studies have been conducted to investigate the prevalence, epidemiology, mechanisms, treatment strategies, and long-term ramifications of hypertension postdonation. These studies are heterogeneous in their population, design, methodology, and outcome measures and have presented contradicting outcomes. Additionally, the absence of a well-matched control group has made it challenging to interpret and generalise the reported findings. As such, it is not possible to definitively conclude that hypertension occurs at a higher rate among donors than the general population. This article will review the evidence of postdonation hypertension prevalence, mechanisms, treatment, and complications.

Risks for donors associated with living kidney donation: meta-analysis

“…−3.24 to −2.15) ml per min per 1.73 m 2 lower than that of non-obese patients. Donor obesity was associated with significantly higher systolic and diastolic BPs both before and 1 year after LKD, although it is not possible to conclude definitively that hypertension occurs at a higher rate among donors than in the general population 45 . Higher rates of proteinuria were associated with donor obesity, but donor BMI did not have an impact on the incidence of intraoperative and postoperative complications.…”

JCV viruria associates with suboptimal recovery of kidney function three years after living kidney donation

“…It is still unclear whether or not there is a significant risk of hypertension in donors compared to the general population. Nevertheless, hypertension is a heterogeneous phenomenon, affecting donors in different degrees and may be influenced by several factors 24 .…”

Living Kidney Donation: Practical Considerations on Setting Up a Program

“…Thus, potential donor candidates with eGFR 60-89 mL/min per 1.73 m 2 could still be considered and the decision to proceed will rely on the work up to exclude additional risk factors to develop ESRD. [14]. It is well accepted that living kidney donors are healthier than the unscreened population, thus their overall cardiovascular and mortality risk does not seem to be increased and post-donation hypertension risk varies with baseline donor traits.…”