RETRACTED: Notoginsenoside R1 protects human renal proximal tubular epithelial cells from lipopolysaccharide-stimulated inflammatory damage by up-regulation of miR-26a

Liu, Jinrong; Hou, Cun; Chen, Xiaoyuan; Wu, Lin; Wang, Xinyue

doi:10.1016/j.cbi.2019.05.053

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…A small fraction of studies believed that NGR1 exerted its function via regulating miRNA expression pattern [32]. For the selected examples, miR-26a [33], miR-23a [34], and miR-132 [35] are found as the targets of NGR1. Herein, we observed that miR-503 was another target of NGR1, as its expression was negative regulated by NGR1.…”

Section: Discussionmentioning

confidence: 99%

Notoginsenoside R1 alleviates high glucose-evoked damage in RSC96 cells through down-regulation of miR-503

Wang

Hao

2019

Artificial Cells, Nanomedicine, and Biotechnology

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Notoginsenoside R1 (NGR1) is a major bioactive ingredient of Radix notoginseng that has promise in treating several diabetes-related diseases, like diabetic nephropathy and diabetic cardiomyopathy. This work is designed to explore if NGR1 has potential in treating diabetic peripheral neuropathy (DPN). A cell model of DPN was made by stimulating RSC96 cells with high glucose. The effects of NGR1 preconditioning were examined by conducting CCK-8 assay, flow cytometry, ROS assay and Western blot. The downstream effector and signalling of NGR1 were then explored by qRT-PCR and Western blot. High glucose incubation led to cell viability loss, apoptosis facilitation, caspase-3 and PARP cleavage, and ROS generation of RSC96 cells. Meanwhile, expression of NGF and BDNF was declined by high glucose. Preconditioning NGR1 significantly protected RSC96 cells against high glucose-evoked damage. And NGR1 prevented high glucose-induced expression of miR-503. The beneficial functions of NGR1 towards high glucose-injured RSC96 cells were impeded by miR-503 overexpression. Further, NGR1 activated PI3K/AKT and b-catenin signalling through a miR-503-dependent way. This paper illustrated the neuroprotective and neurotrophic function of NGR1 in RSC96 cells. The beneficial function may due to its regulation on miR-503 expression and the downstream signalling such as PI3K/AKT and b-catenin.

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Section: Discussionmentioning

confidence: 99%

Notoginsenoside R1 alleviates high glucose-evoked damage in RSC96 cells through down-regulation of miR-503

Wang

Hao

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Notoginsenoside R1 is a promising drug for the prevention and treatment of renal insufficiency through inhibition of the production of inflammatory cytokines induced by ischemic reperfusion and inhibition of oxidative stress (Fan et al, 2020). In vitro, notoginsenoside R1 protects human renal proximal tubular epithelial cells from lipopolysaccharide (LPS)-induced inflammatory injury by upregulating miR-26a and inactivating the NF-κB pathway (Liu et al, 2019b).…”

Section: Mechanisms Of Chinese Herbal Medicines In Treating Kidney DImentioning

confidence: 99%

“…In an in vitro study, paeoniflorin reduced caspase-3 and Bax and increased Bcl-2, suggesting that the apoptosis of podocytes induced by adriamycin was reduced (Lu et al, 2017). Notoginsenoside has been shown to have an anti-apoptotic effect against polymyxin E-induced nephrotoxicity (Zhang et al, 2019e), cisplatin-induced nephrotoxicity (Liu et al, 2014), ischemia-reperfusion injury (Liu et al, 2010), LPS-induced inflammatory damage (Liu et al, 2019b), and diabetic nephropathy (Zhang et al, 2019a). Ginsenoside Rg1 could protect HK-2 cells against LPS-induced apoptosis by activation of the PI3K/AKT pathway and suppression of the NF-κB pathway (Ni et al, 2017a).…”

Section: Anti-apoptotic Effect Of Chinese Herbal Medicinesmentioning

confidence: 99%

Mechanisms and Efficacy of Chinese Herbal Medicines in Chronic Kidney Disease

Zhao

Wang

et al. 2021

Front. Pharmacol.

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As the current treatment of chronic kidney disease (CKD) is limited, it is necessary to seek more effective and safer treatment methods, such as Chinese herbal medicines (CHMs). In order to clarify the modern theoretical basis and molecular mechanisms of CHMs, we reviewed the knowledge based on publications in peer-reviewed English-language journals, focusing on the anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated and antifibrotic effects of CHMs commonly used in kidney disease. We also discussed recently published clinical trials and meta-analyses in this field. Based on recent studies regarding the mechanisms of kidney disease in vivo and in vitro, CHMs have anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic effects. Several well-designed randomized controlled trials (RCTs) and meta-analyses demonstrated that the use of CHMs as an adjuvant to conventional medicines may benefit patients with CKD. Unknown active ingredients, low quality and small sample sizes of some clinical trials, and the safety of CHMs have restricted the development of CHMs. CHMs is a potential method in the treatment of CKD. Further study on the mechanism and well-conducted RCTs are urgently needed to evaluate the efficacy and safety of CHMs.

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“…NG-R1 has been reported to attenuate IR-induced renal dysfunction by suppressing inflammatory responses and inhibiting apoptosis in rats, as showed by downregulated the expression of p38 MAPK and NF-κB signaling pathway and upregulated the expression of Bcl-2 16 (Figure 3). In human renal proximal tubular epithelial cell lines HK-2 and RPTECs, NG-R1 protects against LPS-induced viability reduction, ROS generation, inflammatory stress, and apoptosis by enhancing the expression of miR-26a and inactivating NF-κB signaling pathway 84 (Table 1).…”

Section: Roles Of Ng-r1 In Renal Diseasesmentioning

confidence: 99%

<p>Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases</p>

Liu

Yang

et al. 2020

DDDT

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Notoginsenoside (NG)-R1 is one of the main bioactive compounds from Panax notoginseng (PN) root, which is well known in the prescription for mediating the microcirculatory hemostasis in human. In this article, we mainly discuss NG-R1 in metabolism and the biological activities, including cardiovascular protection, neuro-protection, anti-diabetes, liver protection, gastrointestinal protection, lung protection, bone metabolism regulation, renal protection, and anti-cancer. The metabolites produced by deglycosylation of NG-R1 exhibit higher permeability and bioavailability. It has been extensively verified that NG-R1 may ameliorate ischemia-reperfusion (IR)-induced injury in cardiovascular and neuronal systems mainly by upregulating the activity of estrogen receptor α-dependent phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and nuclear factor erythroid-2-related factor 2 (NRF2) pathways and downregulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. However, no specific targets for NG-R1 have been identified. Expectedly, NG-R1 has been used as a main bioactive compound in many Traditional Chinese Medicines clinically, such as Xuesaitong, Naodesheng, XueShuanTong, ShenMai, and QSYQ. These suggest that NG-R1 exhibits a significant potency in drug development.

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RETRACTED: Notoginsenoside R1 protects human renal proximal tubular epithelial cells from lipopolysaccharide-stimulated inflammatory damage by up-regulation of miR-26a

Cited by 8 publications

References 37 publications

Notoginsenoside R1 alleviates high glucose-evoked damage in RSC96 cells through down-regulation of miR-503

Notoginsenoside R1 alleviates high glucose-evoked damage in RSC96 cells through down-regulation of miR-503

Mechanisms and Efficacy of Chinese Herbal Medicines in Chronic Kidney Disease

<p>Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases</p>

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