RETRACTED: Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide

Weli, Sarmad hayder weli; Yahyazadeh, Ahmad

doi:10.1016/j.jchemneu.2023.102268

Journal of Chemical Neuroanatomy

2023

DOI: 10.1016/j.jchemneu.2023.102268

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RETRACTED: Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide

Sarmad hayder weli Weli

Ahmad Yahyazadeh

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Cited by 2 publications

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Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

Yahyazadeh,

Gur

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Mercury chloride (ME) is a chemical pollutant commonly found in the environment, which can contribute to undesirable health consequence worldwide. The current study investigated the detrimental impact of ME on the cerebellum and spinal cord tissues in 6–8-week-old female rats. We also evaluated the neuroprotective efficacy of β-caryophyllene (BC) against spinal and cerebellar changes caused by ME. Thirty-five young Wistar albino rats were randomly chosen and assigned into five groups: control (CO), olive oil (OI), ME, BC, ME + BC. All samples were analysed by means of unbiased stereological, biochemical, immunohistochemical, and histopathological methods. Our biochemical findings showed that SOD level was significantly increased in the ME group compared to the CO group (p < 0.05). We additionally detected a statistically significant decrease in the number of cerebellar Purkinje cells and granular cells, as well as spinal motor neuron in the ME group compared to the CO group (p < 0.05). In the ME + BC group, the number of Purkinje cells, granular cells, and spinal motor neurons was significantly higher compared to the ME group (p < 0.05). Decreased SOD activity in the ME + BC group was also detected than the ME group (p < 0.05). Immunohistochemical (the tumour necrosis factor-alpha (TNF-α)) and histopathological examinations also exhibited crucial information in each of the group. Taken together, ME exposure was associated with neurotoxicity in the cerebellum and spinal cord tissues. BC treatment also mitigated ME-induced neurological alteration, which may imply its potential therapeutic benefits.

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Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

Yahyazadeh,

Gur

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Inhalation exposure to crude oil vapor induces behavioural deficits by increasing oxidative stress and histopathological changes in rat hippocampus: Quercetin therapeutic approach

Sadeghi

Ghahari

Yousefpour

et al. 2023

Journal of Chemical Neuroanatomy

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RETRACTED: Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide

Cited by 2 publications

References 38 publications

Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

Inhalation exposure to crude oil vapor induces behavioural deficits by increasing oxidative stress and histopathological changes in rat hippocampus: Quercetin therapeutic approach

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