Retracted: MiR‐449c targets c‐Myc and inhibits NSCLC cell progression

Miao, Lijun; Huang, Shifu; Sun, Zhenchang; Gao, Zeng‐Yan; Zhang, Ruixia; Liu, Ying; Wang, Jing

doi:10.1016/j.febslet.2013.03.006

Cited by 48 publications

(40 citation statements)

References 24 publications

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“…According to the results in luciferase reporter assay, the miR-30c was related to the invasion of NSCLC by regulating MTA1. MiRNAs can regulate the target gene expression by binding its 3′-UTR [26,27,28]. However, the mechanism of miR-30c requires further research.…”

Section: Discussionmentioning

confidence: 99%

Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1

Xia

Chen

Zhong

et al. 2013

Cell Physiol Biochem

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Background: The connection between microRNA expression and lung cancer development has been identified in recent literature. However, the mechanism of microRNA has been poorly elucidated in non-small-cell lung cancer (NSCLC). Methods and Results: Comparing with adjacent tissues (n=75), miR-30c has a lower expression in lung cancer specimens (n=75). The knockdown of miR-30c enhanced the invasion of A549 cells; meanwhile, the overexpression of miR-30c could reverse the effect of the knockdown of miR-30c in vitro. A luciferase assay revealed that miR-30c was directly bound to the 3‘-untranslated regions (3‘-UTR) of MTA1. QRT-PCR and western blot shows MTA1 was up-regulated in mRNA and protein levels. The effect taken on the invasion of NSCLC by overexpression of MTA1 works the same as down-regulated miR-30c. Conclusion: miR-30c may play a pivotal role in controlling lung cancer invasion through regulating MTA1in NSCLC.

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Section: Discussionmentioning

confidence: 99%

Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1

Xia

Chen

Zhong

et al. 2013

Cell Physiol Biochem

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“…5D) expression levels of PFKFB3 in MGC-803 cells. Among numerous miRNAs, miR-449c was identified as a novel cancer-related microRNA, and it was reported to inhibit the proliferation and invasion ability of non-small cell lung cancer cells (11). In liver cancer, miR-449c was reported to inhibit the epithelial-mesenchymal transition and metastasis of liver cancer cells (12).…”

Section: Pfkfb3 Is a Direct Downstream Target Of Mir-449c In Gc Cellsmentioning

confidence: 99%

“…miR-449c was recently reported to have important roles in human cancer, such as non-small cell lung cancer (11) and liver cancer (12). miR-449c was demonstrated to inhibit the proliferation and invasion ability of non-small cell lung cancer cells by targeting MYC proto-oncogene, bHLH transcription factor (c-Myc) (11).…”

Section: Introductionmentioning

confidence: 99%

“…miR-449c was demonstrated to inhibit the proliferation and invasion ability of non-small cell lung cancer cells by targeting MYC proto-oncogene, bHLH transcription factor (c-Myc) (11). In liver cancer, miR-449c was demonstrated to target SYR-box 4 (SOX4) and to inhibit the epithelial-mesenchymal transition and metastasis of liver cancer cells (12).…”

Section: Introductionmentioning

confidence: 99%

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miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3

2018

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Abstract. microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decreased miR-449c levels were associated with poor prognosis in GC patients. Overexpression of miR-449c inhibited migration and invasion in SGC-7901 cells, while inhibition of miR-449c enhanced migration and invasion in MGC-803 cells. Furthermore, 6-phosphofructo-2-kinase (PFKFB3) was identified to be a downstream target of miR-449c in GC cells. miR-449c directly regulated the expression of PFKFB3 in GC cells. Overexpression of PFKFB3 abrogated the inhibitory effect of miR-449c on the migration and invasion of GC cells. In conclusion, the present study suggests that miR-449c may be a novel biomarker and potential therapeutic target in GC.

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“…Expression of miR-449 is down-regulated in non-small cell lung cancers (102). Similar to miR-34, overexpression of miR-449 leads to growth arrest of lung cancer cells by targeting myelocytomatosis oncogene and met protooncogene (102,103). Although the activity of miR-449 in ciliogenesis is mainly assigned to the suppression of Notch or centriolar protein, Cp110 (Figure 2) (88), miR-449/34 might play an important role in promoting cell cycle exit, which is essential to initiate the differentiation of airway epithelial cells.…”

Section: Mir-34/449 Function As a Tumor Suppressormentioning

confidence: 99%

The Roles of MicroRNAs and Protein Components of the MicroRNA Pathway in Lung Development and Diseases

Cushing

Jiang

Kuang

et al. 2015

Am J Respir Cell Mol Biol

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Decades of studies have shown evolutionarily conserved molecular networks consisting of transcriptional factors, diffusing growth factors, and signaling pathways that regulate proper lung development. Recently, microRNAs (miRNAs), small, noncoding regulatory RNAs, have been integrated into these networks. Significant advances have been made in characterizing the developmental stage-or cell type-specific miRNAs during lung development by using approaches such as genome-wide profiling and in situ hybridization. Results from gain-or loss-of-function studies revealed pivotal roles of protein components of the miRNA pathway and individual miRNAs in regulating proliferation, apoptosis, differentiation, and morphogenesis during lung development. Aberrant expression or functions of these components have been associated with pulmonary disorders, suggesting their involvement in pathogenesis of these diseases. Moreover, genetically modified mice generated in these studies have become useful models of human lung diseases. Challenges in this field include characterization of collective function and responsible targets of miRNAs specifically expressed during lung development, and translation of these basic findings into clinically relevant information for better understanding of human diseases. The goal of this review is to discuss the recent progress on the understanding of how the miRNA pathway regulates lung development, how dysregulation of miRNA activities contributes to pathogenesis of related pulmonary diseases, and to identify relevant questions and future directions.

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Retracted: MiR‐449c targets c‐Myc and inhibits NSCLC cell progression

Cited by 48 publications

References 24 publications

Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1

Down-Regulation of MiR-30c Promotes the Invasion of Non-Small Cell Lung Cancer by Targeting MTA1

miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3

The Roles of MicroRNAs and Protein Components of the MicroRNA Pathway in Lung Development and Diseases

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