RETRACTED: miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells

Cai, Wei; Jiang, Haitao; Yu, Yifan; Xu, Yong; Zuo, Wenshan; Wang, Shouguo

doi:10.1016/j.biopha.2017.07.158

Cited by 18 publications

(16 citation statements)

References 22 publications

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“…Accumulating evidence has suggested that miRs, prominently those upregulated or downregulated in other types of malignancies, act as either oncogenes or anti-oncogenes, respectively, in RCC. For example, miR-367 exerts oncogenic effects in osteosarcoma and promotes the proliferation, migration and invasion of tumor cells with the regulation of DOC-2/DAB2 interactive protein, which was consistent with the oncogenic role of miR-367 in RCC (12,13). miR-572 is a type of miR that was recently confirmed to be involved in various types of cancer, including chronic lymphocytic leukemia (14), nasopharyngeal carcinoma (15), ovarian cancer (16) and basal cell carcinoma (17).…”

Section: Microrna-572 Functions As An Oncogene and A Potential Biomarsupporting

confidence: 65%

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

Pan

Zhao

et al. 2018

Oncol Rep

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Renal cell carcinoma (RCC) is the third most common urological malignancy in the USA and represents 2‑3% of all adult malignancies. Furthermore, the incidence of RCC has been progressively increasing over recent years. Although the morbidity of treatment has decreased with the use of multidisciplinary synthetic therapy, the prognosis of terminal cancer remains poor, with a 5‑year survival rate of 5‑10%. MicroRNAs (miRs) have been correlated with the regulation of 30‑60% of the protein-coding genes and act as oncogenes or anti‑oncogenes in RCC. Considering this research, miRNAs are likely to be the biomarkers for tumor diagnosis, prognosis and the targets for RCC management. In the present study, 42 formalin‑fixed paraffin‑embedded RCC samples were used. The expression of miR‑572 and the role of miR‑572 in RCC cell proliferation, migration and apoptosis was determined by performing reverse transcription‑quantitative polymerase chain reaction analysis, wound scratch assays, cell proliferation assays, Transwell assays and flow cytometry assays, respectively. Further experiments were conducted to clarify the correlation between miR‑572 expression and clinicopathological variables or overall survival. Furthermore, the expression levels of miR‑572 were evaluated for the prognosis value of patients with RCC. Upregulation of miR‑572 was observed in RCC tissues and RCC cell lines. miR‑572 promoted 786‑O and ACHN cell proliferation and mobility and inhibited early apoptosis. In Cox proportional hazard regression analyses, results of the univariate and multivariate analysis indicated that the patients with low miR‑572 expression had a significantly longer overall survival compared with the patients with high miR‑572 expression (univariate analysis, P=0.037; multivariate analysis, P=0.034). Results of the Kaplan‑Meier survival curves revealed that the patients with downregulated miR‑572 have a significantly longer overall survival compared with the patients with highly expressed miR‑572 (P=0.019). To conclude, the results of the present study suggest that tumor oncogene miR‑572 is a potential biomarker for the diagnosis, treatment and prognosis for RCC.

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Section: Microrna-572 Functions As An Oncogene and A Potential Biomarsupporting

confidence: 65%

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

Pan

Zhao

et al. 2018

Oncol Rep

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“…MiRNA, a key component of the ncRNA family, plays multifaceted roles in controlling cellular functions by repressing target genes [ 36 ]. miR-367 has been reported as an oncogene in uveal melanoma cells [ 37 ], osteosarcoma [ 38 ], medulloblastoma [ 39 ] and non-small cell lung cancer [ 40 , 41 ]. In our study, we also found that miR-367-5p acted as an oncogene in GC cells.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis

et al. 2018

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BackgroundCircular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and certain types of pathological responses, acting as microRNA (miRNA) sponges to regulate gene expression.MethodsCircNet was used to screen potential circRNAs and validated circYAP1 expression levels in 17 GC tissues by quantitative real-time PCR (qRT-PCR) and another 80 paired GC tissues by FISH. CircYAP1 overexpression and knockdown experiments were conducted to assess the effects of circYAP1 in vitro and in vivo, and its molecular mechanism was demonstrated by RNA in vivo precipitation assays, western blotting, luciferase assay and rescue experiments.ResultsCircYAP1 expression level was significantly lower in GC tissues than the adjacent normal tissues, and GC patients with circYAP1 low expression had shorter survival times as compared with those with circYAP1 high expression. Functionally, circYAP1 overexpression inhibited cell growth and invasion in vitro and in vivo, but its knockdown reversed these effects. Further analysis showed that circYAP1 sponged miR-367-5p to inhibit p27 Kip1 expression and GC progression.ConclusionOur findings demonstrate that circYAP1 functions as a tumor suppressor in GC cells by targeting the miR-367-5p/p27 Kip1 axis and may provide a prognostic indicator of survival in GC patients.Electronic supplementary materialThe online version of this article (10.1186/s12943-018-0902-1) contains supplementary material, which is available to authorized users.

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“…Our study confirmed the role for miR‐367‐3p as a tumour suppressive miRNA in cervical cancer. However, there are also studies reporting an oncogenic function of miR‐367‐3p with respect to tumour progression . These findings report a disparate function for miR‐367‐3p in tumour progression and indicate that the precise expression status and function of miR‐367‐3p may be dependent on the type of tumour involved.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐367‐3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5‐mediated Wnt/β‐catenin signalling

Yang

Tian

Wang

et al. 2020

Clin Exp Pharma Physio

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MicroRNA‐367‐3p (miR‐367‐3p) has been previously reported as a cancer‐related miRNA that is dysregulated in various cancer types and functions either as an oncogenic or as tumour suppressive miRNA. However, whether miR‐367‐3p is dysregulated in cervical cancer and, further, whether it contributes to the development and progression of the disease remains unknown. Here, our results demonstrated that miR‐367‐3p expression was markedly decreased in both cervical cancer tissues and cell lines compared with corresponding controls. In vitro experiments revealed that miR‐367‐3p overexpression repressed the proliferation and invasion of cervical cancer cells. Notably, sperm‐associated antigen 5 (SPAG5) was identified as a target gene of miR‐367‐3p. Moreover, decreased expression of miR‐367‐3p was correlated with high expression of SPAG5 in cervical cancer tissue specimens. SPAG5 inhibition or miR‐367‐3p overexpression significantly downregulated Wnt/β‐catenin signalling in cervical cancer cells. However, the antitumour effect mediated by miR‐367‐3p overexpression was partially reversed by SPAG5 overexpression. Overall, these findings demonstrate that miR‐367‐3p overexpression restricts the proliferation and invasion of cervical cancer cells through targeting SPAG5 to downregulate Wnt/β‐catenin signalling, suggesting a mechanism for the tumour suppressive function of miR‐367‐3p in cervical cancer. Our study highlights the involvement of miR‐367‐3p/SPAG5/Wnt/β‐catenin signalling axis in regulating the malignant progression of cervical cancer.

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RETRACTED: miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells

Cited by 18 publications

References 22 publications

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis

MicroRNA‐367‐3p overexpression represses the proliferation and invasion of cervical cancer cells through downregulation of SPAG5‐mediated Wnt/β‐catenin signalling

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