RETRACTED: miR-153-3p Suppresses Inhibitor of Growth Protein 2 Expression to Function as Tumor Suppressor in Acute Lymphoblastic Leukemia

Abstract

Alterations in microRNAs expression can accelerate the development of human cancers. However, the role of miR-153-3p in acute lymphoblastic leukemia remains unknown. The expression of miR-153-3p in acute lymphoblastic leukemia cell lines was measured by quantitative real-time polymerase chain reaction. Effects of miR-153-3p expression on acute lymphoblastic leukemia cell proliferation, migration, and invasion were examined by Cell Counting Kit-8 assay, wound healing assay, and Transwell invasion assay, respectively. We then validated inhibitor of growth protein 2 as a direct target of miR-153-3p through bioinformatics analysis, luciferase activity reporter assay, and Western blot assay. The miR-153-3p expression was decreased in acute lymphoblastic leukemia cell lines. Cell proliferation, migration, and invasion of acute lymphoblastic leukemia were obviously decreased by miR-153-3p overexpression. Moreover, inhibitor of growth protein 2 was validated as a direct target of miR-153-3p and the overexpression of inhibitor of growth protein 2 reversed the suppressive effects of miR-153-3p on acute lymphoblastic leukemia cell behaviors. Based on these results, we provided evidence that miR-153-3p might be a target for the treatment of acute lymphoblastic leukemia.

MicroRNA‐153‐3p regulates cell proliferation and cisplatin resistance via Nrf‐2 in esophageal squamous cell carcinoma

“…MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs that play an essential role in the regulation of gene expression and tumor progression; in addition, these have been linked to chemotherapy resistance . Many studies have suggested that miR‐153 is a tumor suppressor miRNA . miR‐153‐3p has been reported to suppress the proliferation and invasion of melanoma cells by targeting SNAI1 .…”

“…MiR‐153 was shown to downregulate Snail expression by directly targeting the 3‐untranslated region of SNAI1. miR‐153‐3p inhibited proliferation, migration, and invasion of acute lymphoblastic leukemia cells by suppressing inhibitor of growth protein 2 expression . In addition to regulating tumor cell infiltration and metastasis, miR‐153‐3p has also been shown to regulate chemosensitivity of cancer cells.…”

“…21 Many studies have suggested that miR-153 is a tumor suppressor miRNA. [22][23][24][25] miR-153-3p has been reported to suppress the proliferation and invasion of melanoma cells by targeting SNAI1. 24 MiR-153 was shown to downregulate Snail expression by directly targeting the 3-untranslated region of SNAI1.…”

“…miR-153-3p inhibited proliferation, migration, and invasion of acute lymphoblastic leukemia cells by suppressing inhibitor of growth protein 2 expression. 25 In addition to regulating tumor cell infiltration and metastasis, miR-153-3p has also been shown to regulate chemosensitivity of cancer cells. MiR-153-3p has been reported to overcome the resistance of lung cancer cells to gefitinib by downregulating ABCE1.…”

Focus-ING on DNA Integrity: Implication of ING Proteins in Cell Cycle Regulation and DNA Repair Modulation

“…In most cases, decreased levels of ING proteins and mRNAs were associated with bad prognosis, in accordance with their tumor suppressor role. Several studies have revealed an endogenous regulation of ING expression by some miRNA such as miR153-3p for ING2 [13]. (Regulation of ING expression by miRNA and other ncRNA is better reviewed in [14]).…”