Retracted: Maternal and early life stress effects on immune function: relevance to immunotoxicology

Bellinger, Denise L.; Lubahn, Cheri; Lorton, Dianne

doi:10.1080/15476910802483415

Cited by 57 publications

(51 citation statements)

References 270 publications

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“…Wadhwa (2005) suggests that prenatal stress effects are mediated, in part, via maternal-placental-fetal neuroendocrine mechanisms, with placental corticotropin-releasing hormone (CRH) and glucocorticoids playing a central role. He proposes three possible mechanisms of how signals of maternal stress may reach the fetus: trans-placental transport of maternal hormones, reduction in intrauterine blood flow, and stress-induced suppression of maternal immune functions (compare also Bellinger et al 2008;Cottrell and Seckl 2009;Maccari et al 2003;Merlot et al 2008;Welberg and Seckl 2001). Glucocorticoids seem to be the one common link between prenatal stressors, intrauterine growth, and birth weight (Seckl and Meaney 2004;Sloboda et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Cortisol levels in pregnancy as a psychobiological predictor for birth weight

Bolten

Wurmser

Buske‐Kirschbaum

et al. 2010

Arch Womens Ment Health

152

106

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Antenatal maternal stress is thought to negatively affect fetal development, birth outcomes, and infant's development. Glucocorticoids are suggested to be a common link between prenatal stressors and infant's health. However, data on these mechanisms are rare and sometimes conflicting. The objective of this study was to examine the effects of maternal distress during pregnancy on fetal development and birth weight in humans prospectively. This study focuses on cortisol as one mediating the mechanism of the association between maternal distress and birth outcomes. Pregnancy-related and general distress was measured in 81 women with uncomplicated, singleton pregnancies. The rise of salivary cortisol on awakening (CAR) was assessed in weeks 13-18 and 35-37 postmenstrual age of pregnancy. Mothers completed a structured interview, the perceived stress scale, a widely used psychological instrument that provided a global measure of perceived stress, as well as the Prenatal Distress Questionnaire, a self-report questionnaire designed to assess worries and anxiety in pregnancy. Pre-, peri-, and postnatal medical risk factors as well as birth characteristics were extracted from medical records routinely kept by the attending obstetricians. Hierarchical multiple regressions indicate that maternal cortisol levels explained 19.8% of the variance in birth weight and 9% of the variance in body length at birth, even after controlling for gestational age, parity, prepregnancy BMI, smoking, and infant's sex. Newborns of mothers with higher cortisol levels in pregnancy had lower birth weights and were shorter at birth. An ANCOVA for repeated measures indicated that, after controlling for covariates, pregnancy-related as well as general distress in pregnancy did not influence cortisol levels after awakening (area under the curve). No significant associations between perceived stress and anthrometric measures at birth were found. In conclusion, maternal cortisol levels in pregnancy influence intrauterine growth and may be a better predictor for birth outcome than perceived stress.

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Section: Introductionmentioning

confidence: 99%

Cortisol levels in pregnancy as a psychobiological predictor for birth weight

Bolten

Wurmser

Buske‐Kirschbaum

et al. 2010

Arch Womens Ment Health

152

106

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“…A single exposure to social stress in rodents has been found to induce short-term effects on immune responses (37) and long-term consequences on behavior, HPA responsiveness, and immune functions (17,38). Therefore, future studies are needed to investigate whether a single social isolation of piglets during the early neonatal period can also modify sensitivity to stress and infection later in life.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, early life stress is viewed as a major risk factor for the development of mental disorders (15,16) and immunerelated diseases in later life (17). Although the importance of psychosocial factors for offspring development is well established, limited information exists about how the immune and stress systems interact to cope with psychosocial stressors in early postnatal life.…”

mentioning

confidence: 99%

Altered Immunomodulation by Glucocorticoids in Neonatal Pigs Exposed to a Psychosocial Stressor

et al. 2010

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Stressful early life experiences can have short-and long-term effects on neuroendocrine and immune mechanisms of adaptation, which are primarily modulated by glucocorticoids. This study aimed to examine how the stress and immune systems interact to cope with psychosocial stress induced by a single social isolation (4 h) in neonatal pigs at 7, 21, or 35 d of age. This social isolation provoked increased plasma ACTH and cortisol concentrations and reduced TNF-␣ levels but had no significant effect on IL-6 levels. Socially isolated piglets had a higher lipopolysaccharide (LPS)-stimulated proliferative response of peripheral blood mononuclear cells (PBMCs) than controls, whereas concanavalin A (ConA)-induced proliferation was not affected by isolation. A single social isolation also induced a dose-dependent cortisol resistance in ConA-and LPS-stimulated PBMCs compared with controls, which may be an adaptive response in the short term. Moreover, LPS-stimulated cultures from control piglets showed a reduction in cortisol sensitivity with increasing age. Conclusively, these findings provide stress-related measures for the psychophysiological assessment of livestock handling practices but might also have implications for stress and health studies in young animals and humans. (Pediatr Res 68: 473-478, 2010)

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“…Key interspecies differences, such as gestational length, physiological systems and offspring maturity at birth, suggest that the relationship between prenatal stress and offspring development may function differently between animals and humans (Bellinger et al, 2008;Beydoun & Saftlas, 2008). However, it is not ethical or desirable to randomly allocate pregnant women to stressful conditions in order to replicate animal studies, and so prenatal stress research in human populations is largely observational rather than experimental (DiPietro, 2012;King et al, 2012).…”

Section: Methodological Challenges In Human Studies Of Prenatal Stressmentioning

confidence: 99%

“…The strongest evidence of this effect comes from animal PRENATAL MATERNAL STRESS AND CHILD MOTOR DEVELOPMENT [30] studies, which show that a range of prenatal stressors (e.g., restraint, bright lights, social isolation) cause persistent negative effects across a number of developmental areas in offspring, including neurodevelopment, motor development, stress reactivity, cognition, attention, fearful and anxious behaviour, and immune and metabolic functioning (Beijers, Buitelaar, & Weerth, 2014;Beydoun & Saftlas, 2008;Huizink, Mulder, & Buitelaar, 2004). Further, animal studies articulate the nuances in the relationship between prenatal maternal stress and offspring development, with effects dependent on the type of maternal stress, the timing of stress exposure during gestation, the sex of the offspring, and the area of development (Bellinger, Lubahn, & Lorton, 2008). Animal studies have also shown that effects on offspring can be long-lasting, and may even be passed on to subsequent generations (Beijers et al, 2014).…”

Section: Prenatal Stress and Offspring Development: Animal Studiesmentioning

confidence: 99%

Understanding the relationship between disaster-related prenatal maternal stress and child motor development: The QF2011 Queensland Flood Study

Moss¹

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This thesis investigates the relationship between different aspects of disasterrelated prenatal maternal stress and child motor development, explores how stress reactions work together to predict motor development, and proposes a cascade of stress reactions as a psychological mechanism of transmission for the effects of prenatal maternal stress. It examines continuity and change in findings between 16 and 30 months and, finally, looks at whether maternal coping predicts child motor development.At recruitment, mothers (N = 224) exposed to a major flood during pregnancy completed questionnaires assessing flood exposure (QFOSS), peritraumatic distress (PDI) and dissociation (PDEQ), posttraumatic stress (IESR), a cognitive appraisal of the overall flood consequences, and coping (BriefCOPE). At 16 months (N = 145) and 30

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Retracted: Maternal and early life stress effects on immune function: relevance to immunotoxicology

Cited by 57 publications

References 270 publications

Cortisol levels in pregnancy as a psychobiological predictor for birth weight

Cortisol levels in pregnancy as a psychobiological predictor for birth weight

Altered Immunomodulation by Glucocorticoids in Neonatal Pigs Exposed to a Psychosocial Stressor

Understanding the relationship between disaster-related prenatal maternal stress and child motor development: The QF2011 Queensland Flood Study

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