RETRACTED: Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes

Srivastava, Amit Kumar; Ali, Wahid; Singh, Richa; Bhui, Kulpreet; Tyagi, Shilpa; Al-Khedhairy, Abdulaziz A.; Srivastava, Pramod K.; Musarrat, Javed; Shukla, Yogeshwer

doi:10.1016/j.lfs.2011.12.013

Cited by 73 publications

(34 citation statements)

References 32 publications

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“…Oxidative stress may also contribute to DNA damage as shown by a significant positive correlation between DNA fragmentation levels and the oxidative stress parameters (SOD activity and tissue levels of GSH, GSSG, protein carbonyls and MTs). This link was especially evident in experimental groups of mussels co-exposed to n-ZnO and a strong pro-oxidant Tattoo (Calviello et al, 2006;Srivastava et al, 2012;Falfushynska et al, 2013a).…”

Section: Lysosomal Response and Cytotoxicity Markersmentioning

confidence: 86%

The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

et al. 2015

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Section: Lysosomal Response and Cytotoxicity Markersmentioning

confidence: 86%

The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

et al. 2015

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“…In cultured human lymphocytes, isolated from the peripheral blood of healthy non-smoking donors, exposure to Mancozeb ( [1,2- (2-)]zinc) resulted in a significant and dose-dependent induction of CAs and MN. 4 In chick embryos, Maneb incubation significantly increased SCE values at 13.5 g l À1 and at 27 g l À1 when compared with untreated controls. The concentration of 27 g l À1 , which corresponds to 10.8 times the recommended maximum application level for use in the field, suggests a low genotoxic potential in this study.…”

mentioning

confidence: 88%

DNA Damage Induced by Manganese

Bornhorst¹,

Schwerdtle²

2014

Manganese in Health and Disease

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This chapter summarizes the current studies on the genotoxic potential of manganese (Mn) and is thereby points out that the knowledge gained up to now is quite equivocal. Besides reviewing the current literature on Mn-induced DNA damage on a chromosomal as well as a DNA level, possible underlying mechanisms, including disturbances of DNA replication/DNA polymerases as well as DNA damage response pathways, are discussed. Finally, this chapter gives a brief overview of the possible consequences of DNA damage induced by manganese.

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“…In repeated-dose toxicological studies, in addition to effects on the thyroid gland, reversible effects on skeletal muscles were described (Branch et al 1996;IPCS, 1993IPCS, , 1998. Srivastava et al (2012) also determined that mancozeb (it is a combination of Zinc and maneb) exposure can induce genotoxicity and apoptosis in cultured human lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats

Samanci¹,

Arslan²,

Samanci

et al. 2016

Int. J. Morphol.

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SAMANCI, B.; ARSLAN, E.; SAMANCI, S. B.; CAYPINAR, B.; DEVECI, E.; SÖKER, S. & SEKER, U.Effects of polymeric zinc propylen-bis-dithiocarbamate (propineb) on nasal mucosa in rats. Int. J. Morphol., 34(1):85-89, 2016. SUMMARY:The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180-220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue.We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.

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RETRACTED: Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes

Cited by 73 publications

References 32 publications

The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants

DNA Damage Induced by Manganese

Effects of Polymeric Zinc Propylen-Bis-Dithiocarbamate (Propineb) on Nasal Mucosa in Rats

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