RETRACTED: Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN

Dong, Yujuan; Wei, Maohua; Lu, Jin-Gen; Bi, Chongyao

doi:10.1016/j.biopha.2018.08.017

Cited by 41 publications

(28 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is the first lncRNA with highly specific upregulation in liver cancer [79]. HULC expression and functional activities are not only restricted to liver cancer, however, it is also overly expressed in several cancers such as colorectal carcinoma [80,81], oral squamous cell carcinoma [82], gastric carcinoma [83] and BC [84]. Functionally, HULC was found to act as an endogenous sponge that downregulates an array of miRNAs such as miR-372, miR-186 and miR-200a-3p [85,86].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs: Functional regulatory players in breast cancer

Youness

Gad

2019

Non-coding RNA Research

View full text Add to dashboard Cite

Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome has highlighted the pivotal role of such non-coding RNA (ncRNA) molecules in diverse physiological and pathological conditions. Long non-coding RNA (lncRNA) is a recent class of ncRNA molecules that is still in its infancy stage. The main focus of this review is to unravel the importance of lncRNAs in the most prevalent malignancy among females which is Breast Cancer (BC). A specific focus on lncRNAs as prognostic markers among BC patients showing molecular subtype heterogeneity was also tackled in this review. Finally, the functional and the mechanistic roles of such booming ncRNA molecules in shaping the fate of the BC progression have been highlighted.

show abstract

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs: Functional regulatory players in breast cancer

Youness

Gad

2019

Non-coding RNA Research

View full text Add to dashboard Cite

show abstract

“…PCAT6 was reported to increase cell growth by inhibiting colon cancer cell apoptosis [22]. Downregulation of HULC impairs colon cancer cell proliferation in vitro and retards tumor growth in mice by regulation of miR-613/rhotekin (RTKN) [48].…”

Section: Lncrnas Regulate Cell Proliferationmentioning

confidence: 99%

Long noncoding RNAs: functions and mechanisms in colon cancer

2020

View full text Add to dashboard Cite

Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.

show abstract

“…Despite improvements and advances in diagnostic and therapeutic strategies, colon cancer remains the leading cause of cancer-related deaths worldwide (Siegel et al 2018;Chaffer and Weinberg 2011). Most of these deaths are caused by metastatic diseases (Dong et al 2019). Surgical resection is the first line of treatment for colon cancer (Li et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

Sun

Liu

et al. 2020

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Objective Increasing evidence has revealed that mechanical stress and elevated mechanical signals promote malignant tumor transformation and metastasis. This study aimed to explore the function of the mechanically activated ion-channel Piezo1 in the colon cancer metastasis and its potential regulatory mechanism. Methods First, we examined the expression levels of Piezo1 and mitochondrial calcium uniporter (MCU) both in colon cancer tissues and assessed the prognostic value of Piezo1 and MCU in a colon cancer cohort (n = 110). Second, functional assays were performed to investigate the effects of Piezo1 and MCU on colon cancer cell migration, invasion, and mitochondrial membrane potential. Third, we analyzed the expression of Piezo1, MCU, and HIF-1α by overexpressing/silencing each other's expression. Results We found that Piezo1 was up-regulated and MCU was down-regulated in colon cancer tissues. Piezo1 and MCU were both correlated with poor prognosis of patients with colon cancer. Overexpressing Piezo1 and silencing MCU could promote colon cancer cell migration and metastasis, reduce mitochondrial membrane potential, and promote each other's expression. We also found that HIF-1α was up-regulated in colon cancer tissues. Additionally, silencing Piezo1 inhibited the expression of HIF-1α and VEGF, which was contrary to MCU silencing. Intriguingly, Piezo1-overexpressing cells did not regain their migration behaviors when HIF-1α expression was inhibited, which was accompanied with the re-expression of MCU and VEGF. Conclusion In our study, Piezo1 is involved in colon cancer cell metastasis. Furthermore, our findings indicated a possible Piezo1-MCU-HIF-1α-VEGF axis, which still need further exploration.Keywords Colon cancer · Metastasis · Piezo1 · Mitochondrial calcium uniporter · HIF-1α Yanhua Sun and Ming Li have contributed equally to this work.

show abstract

RETRACTED: Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN

Cited by 41 publications

References 24 publications

Long non-coding RNAs: Functional regulatory players in breast cancer

Long non-coding RNAs: Functional regulatory players in breast cancer

Long noncoding RNAs: functions and mechanisms in colon cancer

The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

Contact Info

Product

Resources

About