RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX

Niu, Shizhen; Ni, Yu; Niu, Tong; Gao, Jianwen

doi:10.1016/j.molimm.2019.11.012

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…In this study, it was downregulated Iafter ox-LDL treatment (FC = −14:52, p < 0:05). miR-1908-5p plays an important role in regulating lipid metabolism in blood, and miR-378a-5p/138-5p/34a-5p are important miR-NAs mediating lipid metabolism, tumor angiogenesis, and oxidative stress [32][33][34][35][36]. According to the IPA results, miRNA-target mRNA network, and previous references, miR-138-5p, miR-345-5p, miR-210-5p, miR-34a-5p, miR-1908-5p, miR-1343-3p, miR-485-5p, miR-423-5p, and miR-4488 may serve as potential RNA targets for prognosis and diagnosis of RPE degeneration.…”

Section: Discussionmentioning

confidence: 99%

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

Mao

2020

Oxidative Medicine and Cellular Longevity

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The aim of this study was to investigate the miRNA profiles of nanosized small extracellular vesicles (sEVs) from human retinal pigment epithelial (RPE) cells under oxidative damage. ARPE-19 cells were cultured with ox-LDL (100 mg/L) or serum-free medium for 48 hours, sEVs were then extracted, and miRNA sequencing was conducted to identify the differentially expressed genes (DEGs) between the 2 groups. RNA sequence results were validated using quantitative real-time PCR. The Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes pathway, and ingenuity pathway analyses (IPA) were performed for the DEGs. Results revealed that oxidative stress inhibited RPE cell viability and promoted sEV secretion. A total of 877 DEGs from sEVs were identified, of which 272 were downregulated and 605 were upregulated. In total, 66 enriched GO terms showed that the 3 most significant enrichment terms were cellular processes (biological processes), cell (cellular component), and catalytic activity (molecular function). IPA were used to explore DEGs associated with oxidation damage and further construct a miRNA-target regulatory network. This study identified several DEGs from oxidation-stimulated RPE cells, which may act as potential RNA targets for prognosis and diagnosis of RPE degeneration.

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Section: Discussionmentioning

confidence: 99%

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

Mao

2020

Oxidative Medicine and Cellular Longevity

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10-O-(N N-Dimethylaminoethyl)-Ginkgolide B Methane-Sulfonate (XQ-1H) Ameliorates Cerebral Ischemia Via Suppressing Neuronal Apoptosis

Khadankhuu

Fei

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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Research Progress on the Regulatory Role of MicroRNAs in Spinal Cord Injury

Yang

et al. 2021

Regen. Med.

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Spinal cord injury (SCI) is a severe CNS injury that results in abnormalities in, or loss of, motor, sensory and autonomic nervous function. miRNAs belong to a new class of noncoding RNA that regulates the production of proteins and biological function of cells by silencing translation or interfering with the expression of target mRNAs. Following SCI, miRNAs related to oxidative stress, inflammation, autophagy, apoptosis and many other secondary injuries are differentially expressed, and these miRNAs play an important role in the progression of secondary injuries after SCI. The purpose of this review is to elucidate the differential expression and functional roles of miRNAs after SCI, thus providing references for further research on miRNAs in SCI.

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RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX

Cited by 3 publications

References 29 publications

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

10-O-(N N-Dimethylaminoethyl)-Ginkgolide B Methane-Sulfonate (XQ-1H) Ameliorates Cerebral Ischemia Via Suppressing Neuronal Apoptosis

Research Progress on the Regulatory Role of MicroRNAs in Spinal Cord Injury

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RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX

Cited by 3 publications

References 29 publications

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

Microarray Analysis of Small Extracellular Vesicle-Derived miRNAs Involved in Oxidative Stress of RPE Cells

10-O-(N N-Dimethylaminoethyl)-Ginkgolide B Methane-Sulfonate (XQ-1H) Ameliorates Cerebral Ischemia Via Suppressing Neuronal Apoptosis

Research Progress on the Regulatory Role of MicroRNAs in Spinal Cord Injury

Contact Info

Product

Resources

About

RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX