RETRACTED: Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial

Demiroǧlu, Halûk; Özcebe, Osman; Barışta, İbrahim; Dündar, Semra; Eldem, Bora

doi:10.1016/s0140-6736(99)05131-4

Cited by 66 publications

(18 citation statements)

References 23 publications

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“…Type I IFNs have been used as immunomodulatory agents for the treatment of a variety of autoimmune diseases [1,13,18,23]. Previously, IFNs have been administered via intradermal injections; however, their oral administration has also been found to be effective in recent studies [6,10,31].…”

Section: Discussionmentioning

confidence: 99%

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Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

Suzuki

Sakai

Okada

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

“…For example, intradermal injections of IFN-β have been shown to be effective in clinical trials for multiple sclerosis [1]. Furthermore, intradermal injections of IFN-α have been reported to be beneficial in the treatment of the mucocutaneous lesions, arthritis [23] and intraocular inflammation [13,18] associated with Behçet's disease.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

Suzuki

Sakai

Okada

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

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“…Several other small studies have also shown promising results [160, 161, 162]. A recent randomized control trial, comparing interferon-α2a to colchicine plus penicillin was unfortunately retracted due to fabrication of authorship and possibly the reported data [163]. …”

Section: Treatment Optionsmentioning

confidence: 99%

Uveitis: A Potentially Blinding Disease

Durrani¹,

Meads

Murray³

2004

Ophthalmologica

262

170

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Uveitis (intraocular inflammation) is a potentially blinding group of, probably autoimmune, conditions predominantly occurring in the working age group. Although the aetiology is unknown in most cases, many patients have an associated underlying systemic disease. Central vision loss, in the form of cystoid macular oedema, is the commonest type of visual impairment. Although historical incidence and prevalence data exists, little is known about the degree of vision loss experienced, and the social and financial consequences of having temporary or permanent visual impairment in this age group. The literature is also full of uncontrolled studies and case reports of different modalities of drug therapy for uveitis. This article attempts to raise the awareness of uveitis as an important sight-threatening group of conditions by highlighting the paucity of evidence-based data on epidemiological, quality of life, socioeconomic, and therapeutic aspects.

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“…Patients with acquired immunodeficiency have also been shown to present with reduced serum IFN-α [10]. Since it is known that IFN-α is a cytokine with potent antiviral activity inhibiting viral replication in infected cells [11], it is now used for the treatment of specific viral infections and in the therapy of certain cancers [12, 13, 14, 15]. It has also been reported that IFN-α can influence the regulation of the T cell response by increasing the responsiveness of CD4+ cells to IL-12, resulting in the production of high levels of IFN-γ, and thus resulting in a Th1 cytokine response [16].…”

Section: Introductionmentioning

confidence: 99%

Atopic Phenotype in Children Is Associated with Decreased Virus-Induced Interferon-α Release

Bufe

Gehlhar

Grage-Griebenow

et al. 2002

Int Arch Allergy Immunol

101

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Background: Interferon-α (IFN-α) production in humans is an early event in the nonspecific cellular response to viruses and mediates a wide range of antiviral and immunoregulatory activities. Little is known about the role of IFN-α in allergic disease. Methods: In the present study, we performed a retrospective comparative analysis of 88 children with and without an atopic phenotype for virus-induced IFN-α production in blood cultures. Results: We were able to demonstrate that patients with allergic asthma (aA) produced significantly lower amounts of virus-induced IFN-α than healthy children and patients with nonallergic asthma (naA). Furthermore, the number of eosinophils in atopic children as a marker for allergic inflammation correlated negatively with the IFN-α level in blood cultures. Additionally, we found differences between aA and naA patients with respect to the capacity to produce IFN-γ. Although atopy is thought to be associated with a Th2 cytokine response, in our study, IFN-γ release was not reduced in the allergic children. In contrast, patients with allergic rhinitis showed a significant increase in IFN-γ release compared to naA patients. Conclusions: In our study, an early atopic phenotype was related to a reduction in virus induced IFN-α release from blood cultures. Thus, after further prospective evaluation, the IFN-α level may serve as an additional in vitro marker for the definition of atopy in children.

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RETRACTED: Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet's disease: a randomised trial

Cited by 66 publications

References 23 publications

Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

Uveitis: A Potentially Blinding Disease

Atopic Phenotype in Children Is Associated with Decreased Virus-Induced Interferon-α Release

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