“…Importantly, the tumor microenvironment is a research hotspot of tumor progression, and hypoxia and in ammation are the important factors. And the between the ten positively related and negatively related genes, GRIN1, SNAP25, PDIA6 and so on were reported to be connected with the hypoxia pathway [24][25][26], and GRIN1, CHGA, BCLL12, SERBP1, CPLX1 and so on were reported to be related to in ammation [27][28][29][30][31][32], which further proved that CPLX2 may be related to hypoxia and in ammation. CPLX2 may prevent tumor growth by inhibiting the pathway of hypoxia and in ammation, according to the above prediction.…”