RETRACTED: Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice

Zhu, Xiangxiang; Zhang, Zilei; Yang, Xin; Qi, Longkai; Guo, Yinrui; Tang, Xiaocui; Xie, Yizhen; Chen, Diling

doi:10.1016/j.brainres.2022.148038

Cited by 7 publications

(3 citation statements)

References 71 publications

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“…Desulfovibrionacea encompasses a family of anaerobic Gram-negative bacteria, and they have been associated with inflammation and disruption of the gut-microbiota-brain axis in part through production of H 2 S ( Yang et al, 2017 ; Zhu et al, 2019 ). Consistent with our study, increased Desulfovibrionacea abundance in mice has been associated with neurological disorders including restraint-induced depression as well as symptoms reminiscent of Alzheimer’s disease and Parkinson’s disease ( Han et al, 2021 ; Murros et al, 2021 ; Zhao et al, 2021 ; Yang et al, 2022 ; Zhu et al, 2022 ). P. distasonis , on the other hand, is rich in BA metabolizing enzymes, including bile salt hydrolase and 7-α hydroxyoxidase, and can efficiently transform primary BAs into secondary BAs such as conversion of CA to 7-ketoDCA ( Wang et al, 2019 ).…”

Section: Discussionsupporting

confidence: 90%

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

Yuan

Renaud

et al. 2022

Front. Pharmacol.

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Chaihu-Shugan-San (CSS) is a traditional botanical drug formula often prescribed to treat depression in oriental countries, but its pharmacotherapeutic mechanism remains unknown. It was recently reported that CSS alters the composition of intestinal microflora and related metabolites such as bile acids (BAs). Since the intestinal microflora affects physiological functions of the brain through the gut-microbiota-brain axis, herein we investigated whether CSS altered BA levels, gut microflora, and depression-like symptoms in chronic unpredictable mild stress (CUMS) mice, a well-established mouse model of depression. Furthermore, we determined whether BA manipulation and fecal microbiota transplantation altered CSS antidepressant actions. We found that the BA chelator cholestyramine impaired the antidepressant effects of CSS, which was partially rescued by dietary cholic acid. CSS increased the relative abundance of Parabacteroides distasonis in the colon of CUMS mice, and increased serum levels of various BAs including hyocholic acid (HCA) and 7-ketodeoxycholic acid (7-ketoDCA). Furthermore, gut bacteria transplantation from CSS-treated mice into untreated or cholestyramine-treated CUMS mice restored serum levels of HCA and 7-ketoDCA, alleviating depression-like symptoms. In the hippocampus, CSS-treated mice had decreased expression of genes associated with BA transport (Bsep and Fxr) and increased expression of brain-derived neurotrophic factor and its receptor, TrkB. Overall, CSS increases intestinal P. distasonis abundance, leading to elevated levels of secondary BAs in the circulation and altered expression of hippocampal genes implicated in BA transport and neurotrophic signaling. Our data strongly suggest that the gut microbiota-brain axis contributes to the potent antidepressant action of CSS by modulating BA metabolism.

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Section: Discussionsupporting

confidence: 90%

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

Yuan

Renaud

et al. 2022

Front. Pharmacol.

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“…This article has been retracted: Aging has completed its investigation of this paper. We confirmed that the fecal transplantation data from the model group (the APP/PS1 mice) presented in Figure 2 (panels 2C-2F) were reused in a Brain Research article [1] published two years after this one. In addition, we found Western blot duplication presented in Figure 3, panels 3C (Expression of the proteins AChE, AMP, CHRNA1 and CHRNB1 in the brain tissues of SAMP8 mice after infection of over-expressing circNF1-419 AAV) and 3E (Expression of the proteins AChE, AMP, CHRNA1 and CHRNB1 in the brain tissues of 2-month-old mice after infection of over-expressing circNF1-419 AAV).…”

supporting

confidence: 75%

Retraction: CircNF1-419 improves the gut microbiome structure and function in AD-like mice

Chen

Guo

et al. 2023

Aging

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“…Sowohl der Hericium wie der Reishi haben sich üb-rigens auch zur Unterstützung der sog. Darm-Hirn-Achse bewährt [6]. Ein gutes Beispiel zur Verdeutlichung dieser starken Verbindung zwischen Verdauungstrakt und Nervensystem kennt sicher jeder, nämlich dass uns etwa bei bestimmten Gedanken ganz plötzlich der Appetit vergeht.…”

Section: Therapeutische Effekte Verschiedener Vitalpilzeunclassified

Magen-Darm-Erkrankungen mit Heil- und Vitalpilzen erfolgreich therapieren

Ogroske

2024

Erfahrungsheilkunde

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ZusammenfassungUngesunde Ernährung, ein hektischer, stressreicher Lebensstil, emotionale Belastungen, Bewegungsmangel sowie die Einnahme bestimmter Medikamente haben einen negativen Einfluss auf unsere Magen-Darm-Gesundheit. Völlegefühl, Blähungen, Reizdarm, Sodbrennen, Durchfälle oder auch anhaltende Verstopfung sind weit verbreitete Symptome, die die Lebensqualität der Betroffenen erheblich beeinträchtigen, insbesondere wenn sie sich chronifizieren. Darüber hinaus leiden viele Menschen in den modernen Gesellschaften unter schwerwiegenden Magen-Darm-Erkrankungen wie Morbus Crohn oder Colitis ulcerosa. Der Gesundheitszustand unseres Verdauungstraktes hat auch einen großen Einfluss auf unsere Gesamtgesundheit. Mit den in der Mykotherapie eingesetzten Vitalpilzen – sie werden synonym auch Heil- bzw. medizinisch wirksame Pilze genannt – steht eine effektive naturheilkundliche Therapieoption zur Verfügung. So leisten Vitalpilze einen wertvollen Beitrag zur Wiederherstellung und Erhaltung der Magen- und Darmgesundheit und einer intakten Verdauung. Ihr Einsatz hat sich bei der Behandlung einer Vielzahl von Magen-Darm-Erkrankungen bewährt.

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RETRACTED: Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice

Cited by 7 publications

References 71 publications

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

Retraction: CircNF1-419 improves the gut microbiome structure and function in AD-like mice

Magen-Darm-Erkrankungen mit Heil- und Vitalpilzen erfolgreich therapieren

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