Retracted:<i>Lmx1b</i>-Controlled Isthmic Organizer Is Essential for Development of Midbrain Dopaminergic Neurons

Guo, Chao; Qiu, Hai Yan; Shi, Ming; Huang, Ying; Johnson, Randy L.; Rubinstein, Marcelo; Chen, Sheng Di; Ding, Yu

doi:10.1523/jneurosci.3267-08.2008

Cited by 8 publications

(11 citation statements)

References 46 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parkinson's disease is a neurodegenerative disorder that involves specific degeneration of dopamine neurons within the substantia nigra regions of the brain. During embryogenesis, dopamine neurons of the substantia nigra arise from the developing ventral midbrain, also known as the ventral mesencephalon, and can be identified by the combination of transcription factors some of which are: Pitx3, Lmx1a, Nurr1, En1, Foxa2 [31][32][33][34][35][36] . Dopamine neurons also arise in the developing forebrain regions; however, these neurons show a different transcription expression profile during development [37] .…”

Section: Dopamine Neuronsmentioning

confidence: 99%

Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

Denham

Dottori²

2009

Neurosignals

View full text Add to dashboard Cite

Neural differentiation from embryonic stem cells involves progressive stages of neural induction, expansion and maintenance of neural stem/progenitor cells, and differentiation to neurons and glia. Our understanding of the signals involved in each of these processes is primarily based on our knowledge of neural development during embryogenesis. This review will focus on the signalling pathways that have been identified to play a role in neural differentiation of human embryonic stem cells (hESCs), including their induction to neuroectoderm, maintenance and expansion of hESC-derived neurospheres, differentiation to neurons and specification to specific neuronal lineages. Understanding the signals involved in each of these stages is important for optimising methods to derive specific cell types for transplantation therapies, as well as for providing insight into the mechanisms of human neurogenesis.

show abstract

Section: Dopamine Neuronsmentioning

confidence: 99%

Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

Denham

Dottori²

2009

Neurosignals

View full text Add to dashboard Cite

show abstract

“…2008). This conclusion is also supported by the fact that normal midbrain dopaminergic neurons are present in Lmx1b −/– mice when the inductive activity of isthmic organizer is rescued by Wnt1 ‐driven Lmx1b expression in the isthmus and when Lmx1b in specifically deleted in differentiating dopaminergic neurons (Guo et al . 2008).…”

Section: Lmx1b In Brain Development and Functionmentioning

confidence: 80%

“…Furthermore, misexpression of Lmx1b induces ectopic Fgf8 expression non-cell-autonomously by inducing Wnt1, but it represses Fgf8 expression in the isthmus cell-autonomously, possibly mediated by Grg4 in chick embryos (Matsunaga et al 2002). In addition, expression of Lmx1b transgene by Wnt1 promoter in Lmx1b -/mice is able to restore Fgf8 and Wnt1 expression as well as normal development of tectum and cerebellum (Guo et al 2008). Thus, Lmx1b is required and sufficient for the initiation of Fgf8 expression in the early formation of isthmic organizer, and then Lmx1b may restrict the Fgf8 expression domain to anterior limit of the hindbrain by repressing Fgf8 expression cell-autonomously and inducing Fgf8 non-cellautonomously.…”

Section: Lmx1b In Brain Development and Functionmentioning

confidence: 99%

“…2002). In addition, expression of Lmx1b transgene by Wnt1 promoter in Lmx1b −/– mice is able to restore Fgf8 and Wnt1 expression as well as normal development of tectum and cerebellum (Guo et al . 2008).…”

Section: Lmx1b In Brain Development and Functionmentioning

confidence: 99%

“…2007), because conditional inactivation of Lmx1b expression in the whole brain by Nestin‐Cre after the formation of isthmic organizer (i.e. E10.5) did not affect the development of midbrain dopaminergic neurons (Guo et al . 2008).…”

Section: Lmx1b In Brain Development and Functionmentioning

confidence: 99%

See 2 more Smart Citations

Manifold functions of the Nail‐Patella Syndrome gene Lmx1b in vertebrate development

Dai

Johnson²,

Ding

2009

Dev Growth Differ

View full text Add to dashboard Cite

The LIM (Lin-1, Isl-1 and Mec-3)-homeodomain transcription factor 1 beta (Lmx1b) is widely expressed in vertebrate embryos, and is implicated in the development of diverse structures such as limbs, kidneys, eyes and brains. LMX1B mutations in humans cause an autosomal dominant inherited disease called nail-patella syndrome (NPS), which is characterized by abnormalities of the arms and legs as well as kidney disease and glaucoma. Expression of Lmx1b in the dorsal compartment of growing limb buds is critical for specification of dorsal limb cell fates and consequently dorsoventral patterning of limbs. In addition, Lmx1b is involved in the differentiation of anterior eye structures, formation of the glomerular basement membrane in kidneys and development of the skeleton, especially calvarial bones. In the central nervous system, Lmx1b controls the inductive activity of isthmic organizer, differentiation and maintenance of central serotonergic neurons, as well as the differentiation and migration of spinal dorsal horn neurons. Although details of the genetic programs involved in these developmental events are largely unknown, it is suggested that Lmx1b plays central roles in fate determination or cell differentiation in these tissues. Sustained expression of Lmx1b in the postnatal and mature mouse brain suggests that it also plays important roles in brain maturation and in the regulation of normal brain functions. This review aims to highlight recent insights into the many activities of Lmx1b in vertebrates.

show abstract

Molecular ontology of the parabrachial nucleus

Karthik

Huang

Delgado

et al. 2022

J of Comparative Neurology

View full text Add to dashboard Cite

Diverse neurons in the parabrachial nucleus (PB) communicate with widespread brain regions. Despite evidence linking them to a variety of homeostatic functions, it remains difficult to determine which PB neurons influence which functions because their subpopulations intermingle extensively. An improved framework for identifying these intermingled subpopulations would help advance our understanding of neural circuit functions linked to this region. Here, we present the foundation of a developmental‐genetic ontology that classifies PB neurons based on their intrinsic, molecular features. By combining transcription factor labeling with Cre fate‐mapping, we find that the PB is a blend of two, developmentally distinct macropopulations of glutamatergic neurons. Neurons in the first macropopulation express Lmx1b (and, to a lesser extent, Lmx1a) and are mutually exclusive with those in a second macropopulation, which derive from precursors expressing Atoh1. This second, Atoh1‐derived macropopulation includes many Foxp2‐expressing neurons, but Foxp2 also identifies a subset of Lmx1b‐expressing neurons in the Kölliker–Fuse nucleus (KF) and a population of GABAergic neurons ventrolateral to the PB (“caudal KF”). Immediately ventral to the PB, Phox2b‐expressing glutamatergic neurons (some coexpressing Lmx1b) occupy the KF, supratrigeminal nucleus, and reticular formation. We show that this molecular framework organizes subsidiary patterns of adult gene expression (including Satb2, Calca, Grp, and Pdyn) and predicts output projections to the amygdala (Lmx1b), hypothalamus (Atoh1), and hindbrain (Phox2b/Lmx1b). Using this molecular ontology to organize, interpret, and communicate PB‐related information could accelerate the translation of experimental findings from animal models to human patients.

show abstract

Retracted:Lmx1b-Controlled Isthmic Organizer Is Essential for Development of Midbrain Dopaminergic Neurons

Cited by 8 publications

References 46 publications

Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

Signals Involved in Neural Differentiation of Human Embryonic Stem Cells

Manifold functions of the Nail‐Patella Syndrome gene Lmx1b in vertebrate development

Molecular ontology of the parabrachial nucleus

Contact Info

Product

Resources

About