RETRACTED: Enhanced antitumor efficacy of 5-fluorouracil loaded methoxy poly(ethylene glycol)–poly(lactide) nanoparticles for efficient therapy against breast cancer

Zhu, Yong‐Guan; Qiu, Xiang; Wang, Yu; Zhang, Daoyun; Luo, Jiancheng; Ning, Jia; Zhang, Zhong-Tao

doi:10.1016/j.colsurfb.2015.02.048

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. 5‐FU has been given systemically for anal, breast, colorectal, esophageal, stomach, pancreatic, and skin cancers, especially for head and neck cancers (Naguib and others ; Yuan and others ). 5‐FU interferes with nucleoside metabolism and interferes with the DNA synthesis and RNA function, leading to the cell cycle arrest and cell apoptosis (Le and others ).…”

Section: Resultsmentioning

confidence: 99%

Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180‐Bearing/Residual Mouse

Pan

Yang

Zhang

et al. 2016

Journal of Food Science

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Chitosan oligosaccharides (COSs) are hydrolysate mixture of chitin and possess various biomedical properties, such as antimicrobial, immunoenhancing, and antitumor effects. Antiproliferation activity of COS and commercially available samples was compared in the terms of A549 and HCT-116 cells. Ten tumor cells were used to estimate cytotoxicity of COS. Although there were some researches on the antitumor effects of COS, we highlighted the in vivo antitumor activities of COS administrated orally and intraperitoneally on S180-bearing/residual mouse. Results turned out that in vitro IC values of COS were 48.6 ± 7.0 to 1329.9 ± 93.4 μg/mL against 10 different tumor cell lines. Then, the in vivo experiments proved that the inhibition rate was high up to 58.5%. Significant cell death and necrosis were observed in COS-treated groups by histological analysis. COS stimulated the mRNA expression of tumor necrosis factor alpha. In summary, COS may be considered promising candidate as antitumor functional food or pharmaceutic adjuvant in oncotherapy, especially for patients after surgical resection.

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Section: Resultsmentioning

confidence: 99%

Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180‐Bearing/Residual Mouse

Pan

Yang

Zhang

et al. 2016

Journal of Food Science

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“…Local applications or missile treatments are possible for AMPs, irrespective of their toxicity. A novel nanocarrier was used to deliver the anticancer drug 5-fluorouracil to increase antitumor efficacy against breast cancer cells in vitro and in vivo ( 118 ). Eguchi et al explained that magnetic anticancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies ( 119 ).…”

Section: Conclusion and Future Challengesmentioning

confidence: 99%

The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs

et al. 2015

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Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge and is amphiphilic, and can eliminate pathogenic microbes directly via electrostatic attraction toward negatively charged bacterial membranes. A number of studies have shown that LL-37 participates in various host immune systems, such as inflammatory responses and tissue repair, in addition to its antibacterial properties. Moreover, recent evidence suggests that it is also involved in the regulation of cancer. Indeed, previous studies have suggested that human LL-37 is involved in carcinogenesis via multiple reporters, such as FPR2 (FPRL1), epidermal growth factor receptor, and ERBb2, although LL-37 and its fragments and analogs also show anticancer effects in various cancer cell lines. This discrepancy can be attributed to peptide-based factors, host membrane-based factors, and signal regulation. Here, we describe the association between AMPs and cancer with a focus on anticancer peptide functions and selectivity in an effort to understand potential therapeutic implications.

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“…In addition, the in vitro biodistribution of HGK-NSps in MCF-7 tumor-bearing mice was also examined. As seen in Figure S2 in the Supplementary material , HGK-NSps mainly distributed in the liver and spleen after intravenous injection and barely benefited from enhanced permeability and retention (EPR) effect that may lead to more drug accumulation in tumor (Li M et al., 2020 ) (Hong et al., 2016 ; Jain, 2005 ; Yuan Z et al., 2015 ). The reasons behind were probably related to the large particle size or the specific surface property or the interior structural property of HGK-NSps.…”

Section: Resultsmentioning

confidence: 99%

Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer

Li²,

et al. 2020

Drug Delivery

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Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nanosuspensions by antisolvent precipitation method and investigated their characterization, stability, hemolysis probability, release behavior in vitro , antitumor activity in vitro and in vivo , and preliminary safety through acute toxicity experiments. The resultant HGK nanosuspensions (HGK-NSps) showed an average diameter of (261.1 ± 4.8 nm), a narrow particle size distribution (PDI of 0.12 ± 0.01), spherical morphology, high drug-loading content (39.9 ± 2.3%, w/w), and good stability in various physiological media. HGK-NSps was safe for intravenous injection at low concentration and HGK was slowly released from the obtained nanosuspensions. HGK-NSps showed stronger cytotoxicity than free HGK against many tumor cells in vitro . Especially against MCF-7 cells, the IC 50 value was decreased to 1.0 μg/mL, 5-fold lower than the HGK solution. In the in vivo antitumor activity study HGK-NSps (40 mg/kg) displayed a similar therapeutic effect to that of the paclitaxel injection (8 mg/kg). The preliminary acute toxicity test showed that even at the highest dose of 360 mg/kg (iv), HGK-NSps had 100% of mice survival and all the mice were in a good state, suggesting a maximum tolerated dose more than 360 mg/kg. The effective antitumor effect and good tolerance showed HGK-NSps were likely to become a safe and effective antitumor drug for the treatment of breast cancer in the future.

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RETRACTED: Enhanced antitumor efficacy of 5-fluorouracil loaded methoxy poly(ethylene glycol)–poly(lactide) nanoparticles for efficient therapy against breast cancer

Cited by 12 publications

References 25 publications

Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180‐Bearing/Residual Mouse

Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180‐Bearing/Residual Mouse

The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs

Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer

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