RETRACTED: Effects of total parathyroidectomy treatment on parathyroid hormone levels, recurrent laryngeal nerve function, and the rate of infection complications of secondary hyperparathyroidism patients under image information health monitoring by magnetic resonance imaging

Jia, Fucang; Xue, Yongbiao; Li, Kai; Jing, Ying; Li, Dandan; Zhao, Hanhui; Li, Bo; Liu, Wenyuan

doi:10.1016/j.neulet.2020.135195

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“…No cases of adynamic bone disease or deaths were observed. Numerous studies worldwide [ 8 , 19 , 20 ] have also confirmed the efficacy of tPTX in the treatment of SHPT, which had a low recurrence rate and is safe and reliable, with no postoperative complications such as hypocalcemia, hypoparathyroidism, and adynamic bone disease. Therefore, tPTX may be the procedure of choice for patients with renal SHPT who are ineligible for or have no hope of renal transplantation.…”

Section: Discussionmentioning

confidence: 96%

Effect of total parathyroidectomy in patients with secondary hyperparathyroidism: a retrospective study

Gong

Wang

et al. 2022

Int Urol Nephrol

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Purpose To investigate the therapeutic efficacy, feasibility, and safety of total parathyroidectomy (tPTX) in the treatment of secondary hyperparathyroidism (SHPT). Methods The clinical data of 34 SHPT patients admitted to the Department of Nephrology, Yuxi People’s Hospital, from January 2018 to January 2021 who had received tPTX, were retrospectively analyzed. The indications for tPTX were severe SHPT that did not respond to medical treatment and was ineligible for kidney transplantation. tPTX without autotransplantation was adopted to compare the level of symptom relief and changes in serum intact parathyroid hormone (iPTH), blood calcium, and blood phosphorus pre- and postoperatively. Results In 34 patients, 142 parathyroid glands were removed, including 21 ectopic parathyroid glands (14.78%). Six patients (17.64%, 6/34) had supernumerary parathyroid glands. At 6 h postoperatively, arthralgia and bone pain were significantly reduced to almost zero in 94.12% (32/34) of patients. At 24 h postoperatively, relief of bone pain and improvement of limb movement were observed in 100% (34/34) of patients, and pruritus almost disappeared in 86.36% (19/22) of patients. There were significant differences in iPTH (χ2 = 134.93, P < 0.05), calcium (χ2 = 23.02, P < 0.05), and phosphorus (χ2 = 102.11, P < 0.05) levels preoperatively and 40 min, 24 h, 1 week, half a year, and last available (> 1 year) postoperatively. The patients were followed up for 15–47 months (median 33 months). Hypoparathyroidism was observed in three patients, who underwent neck dissection or partial thymotomy concurrently for different reasons. No intractable hypocalcemia or adynamic bone disease occurred during the follow-up period. Conclusion In SHPT patients who were ineligible for renal transplantation, tPTX was effective, safe, and reliable, with a low recurrence rate. However, when tPTX was performed alone without autologous transplantation, bilateral neck exploration was sufficient, and central neck dissection and thymic resection were inadvisable.

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Section: Discussionmentioning

confidence: 96%