RETRACTED: Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy

Liu, Fen; Sun, Wei-Wei; Wang, Ying; Hu, Liqun; Dai, Pengcheng; Tian, Chang-Fu; Wang, Ting‐Hua

doi:10.1016/j.neulet.2008.09.066

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…Muitas destas pesquisas foram úteis, mas são muito discutíveis do ponto vista ético (40)(41)(42)(43)(44)(45)(46) . Em gatas submetidas à ovariohisterectomia (OH), a EA em E36 e vesícula biliar (VB) 34 diminuiu o consumo de anestésico e promoveu estabilidade cardiorrespiratória, sendo superior à AP falsa sem EA (47) e ao uso da morfina (48) .…”

Section: Resultsunclassified

Estudo Retrospectivo De 98 Felinos Submetidos À Acupuntura Atendidos Em Serviço De Reabilitação E Dor Crônica

Silva

Joaquim²,

Luna

et al. 2018

Ciênc. anim. bras.

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ResumoEste estudo retrospectivo avaliou os casos clínicos de felinos atendidos em Serviço de Reabilitação e Dor Crônica, durante 13 anos, totalizando 98 prontuários. Os objetivos deste estudo foram caracterizar o perfil do paciente atendido e avaliar a eficácia da acupuntura (AP) e dos métodos associados a esta técnica no tratamento de doenças em felinos e respectiva evolução clínica. Constatou-se que 69,7% dos pacientes melhoraram após tratamento com AP, 16,7% não apresentaram resposta significativa e 13,6% vieram a óbito. Não foram registrados casos de piora relacionados ao tratamento com AP, embora, dos nove animais que vieram a óbito, três foram devido à progressão da doença primária tratada exclusivamente com AP. As principais afecções tratadas foram relacionadas ao sistema nervoso -sobretudo trauma medular e encefálico -em que se registrou uma melhora em 53,7% dos animais. O tratamento foi considerado eficaz quando os pacientes recuperaram a capacidade normal de deambulação e em casos de doenças medulares quando o escore neurológico mudou de IV (grave) ou V (muito grave) para I (normal) ou II (leve alteração). A técnica de agulha seca foi a mais utilizada para os tratamentos, com 94,7% de prevalência, seguida da eletroacupuntura (30,6%) e da laserpuntura (21,4%). O número de sessões totais de AP foi em média de 6,97±14,97, sendo as mesmas semanais. Conclui-se que o estímulo de acupontos utilizando diferentes métodos foi eficiente para tratar a maioria dos gatos com diversas condições clínicas, evidenciando que esta espécie provavelmente responde tão bem como os cães após o tratamento de AP.

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Section: Resultsunclassified

Estudo Retrospectivo De 98 Felinos Submetidos À Acupuntura Atendidos Em Serviço De Reabilitação E Dor Crônica

Silva

Joaquim²,

Luna

et al. 2018

Ciênc. anim. bras.

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“…Increases in the number of GAP-43-IRs indicate the regrowth of cones and synaptic formation in the spinal cord following injury (9). EA has been demonstrated to promote the recovery of sensory or motor functions in patients with SCI (5) and increase neuroplasticity in de-afferentated spinal cords (6,7). Additional reports have shown that EA-induced increases in the expression of IGF-1 in the spared L6 DRG and associated dorsal horns may be associated with the intraspinal sprouting of DRG neurons in de-afferentated cats subjected to adjacent dorsal root ganglionectomies (26).…”

Section: Discussionmentioning

confidence: 99%

Electro-acupuncture-induced neuroprotection is associated with activation of the IGF-1/PI3K/Akt pathway following adjacent dorsal root ganglionectomies in rats

Chen

et al. 2018

Int J Mol Med

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The aim of the present study was to investigate the putative role and underlying mechanisms of insulin-like growth factor 1 (IGF-1) in mediating neuroplasticity in rats subjected to partial dorsal root ganglionectomies following electro-acupuncture (EA) treatment. The rats underwent bilateral removal of the L1-L4 and L6 dorsal root ganglia (DRG), sparing the L5 DRG, and were subsequently subjected to 28 days of EA treatment at two paired acupoints, zusanli (ST 36)-xuanzhong (GB 39) and futu (ST 32)-sanyinjiao (SP 6), as the EA Model group. Rats that received partial dorsal root ganglionectomies without EA treatment served as a control (Model group). Subsequently, herpes simplex virus (HSV)-IGF-1, HSV-small interfering (si) RNA-IGF-1 and the associated control vectors were injected into the L5 DRG of rats in the EA Model group. HSV-IGF-1 transfection enhanced EA-induced neuroplasticity, which manifested as partial recovery in locomotor function, remission hyperpathia, growth of DRG-derived spared fibers, increased expression of phosphorylated (p-) phosphatidylinositol 3-kinase (PI3K) and Akt, and increased pPI3K/PI3K and pAkt/Akt expression ratios. By contrast, HSV-siRNA-IGF-1 treatment attenuated these effects induced by HSV-IGF-1 transfection. The results additionally demonstrated that HSV-IGF-1 transfection augmented the outgrowth of neurites in cultured DRG neurons, and interference of the expression of IGF-1 retarded neurite outgrowth. Co-treatment with a PI3K inhibitor or Akt siRNA inhibited the aforementioned effects induced by the overexpression of IGF-1. In conclusion, the results of the present study demonstrated the crucial roles of IGF-1 in EA-induced neuroplasticity following adjacent dorsal root ganglionectomies in rats via the PI3K/Akt signaling pathway.

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“…Therefore, our data showed that EA could promote GM fiber regeneration and restoration of nerves innervating the GM and motor units, indicating that EA had multiple effects. Indeed, in previous studies, EA treatment has been shown to promote the continuous growth of glial cells (i.e., Schwann cells) [ 22 ] and enhance the synthesis of neurotrophic factors, such as nerve growth factor [ 23 ], ciliary neurotrophic factor [ 24 ], NT-3/NT-4 [ 25 ], and IGF-1 [ 26 ], which play important roles in the regeneration of injured nerves [ 27 ]. Huang et al [ 13 ] showed that EA increased the number and diameter of axons, thickened the myelin sheath, and increased the number of motor neurons during the delayed recovery of the sciatic nerve, thereby promoting the functional recovery and regeneration of nerves.…”

Section: Discussionmentioning

confidence: 99%

Effects of electroacupuncture on recovery of the electrophysiological properties of the rabbit gastrocnemius after contusion: an in vivo animal study

Liu

Wang

Luo

et al. 2015

BMC Complement Altern Med

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BackgroundOur preliminary studies indicated that electroacupuncture (EA) at the ST36 and Ashi acupoints could promote regeneration of the rabbit gastrocnemius (GM) by improving microcirculation perfusion, promoting the recovery of myofiber structures, and inhibiting excessive fibrosis. However, the effects of EA on recovery of the electrophysiological properties of the GM after contusion are not yet clear. Thus, the purpose of this study was to investigate the effects of EA at the Zusanli (ST36) and Ashi acupoints with regard to recovery of the electrophysiological properties of the rabbit GM after contusion.MethodsForty-five rabbits were randomly divided into three groups: normal, contusion, and EA. After an acute GM contusion was produced (in rabbits in the contusion and EA groups), rabbits in the EA group were treated with electrostimulation at the ST36 and Ashi acupoints with 0.4 mA (2 Hz) for 15 min. The contusion group received no EA treatment. At different time points (7, 14, and 28 days) after contusion, we performed surface electromyography (EMG) and measured the nerve conduction velocity (NCV) of the GM and the GM branch of the tibial nerve. We also examined acetylcholinesterase (AchE) and Agrin expression in the neuromuscular junction (NMJ) via immunohistochemistry.ResultsCompared with the contusion group, the EMG amplitude and NCV in rabbits in the EA group were significantly higher at all time points after contusion. AchE and Agrin expression in the EA group were significantly higher than those in the contusion group.ConclusionsOur results showed that EA at the ST36 and Ashi acupoints effectively promoted recovery of the electrophysiological properties of the rabbit GM after contusion. The effects of EA were realized by promotion of the regeneration of myofibers and nerve fibers, as well as acceleration of NMJ reconstruction by upregulation of AchE and Agrin expression in the motor endplate area.

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RETRACTED: Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy

Cited by 9 publications

References 32 publications

Estudo Retrospectivo De 98 Felinos Submetidos À Acupuntura Atendidos Em Serviço De Reabilitação E Dor Crônica

Estudo Retrospectivo De 98 Felinos Submetidos À Acupuntura Atendidos Em Serviço De Reabilitação E Dor Crônica

Electro-acupuncture-induced neuroprotection is associated with activation of the IGF-1/PI3K/Akt pathway following adjacent dorsal root ganglionectomies in rats

Effects of electroacupuncture on recovery of the electrophysiological properties of the rabbit gastrocnemius after contusion: an in vivo animal study

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