RETRACTED: Dietary Allium hookeri reduces inflammatory response and increases expression of intestinal tight junction proteins in LPS-induced young broiler chicken

Lee, Youngsub; Lee, Sung-Hyen; Gadde, Ujvala Deepthi; Oh, Seung Jin; Lee, Sung-jin; Lillehoj, Hyun S.

doi:10.1016/j.rvsc.2017.03.019

Cited by 50 publications

(40 citation statements)

References 25 publications

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“…In this study, the mRNA expression of IL-8 was lower in the caecum of the OB group compared to the CON group, while the mRNA expressions of IL-8, NF-κB, and TNF-α were lower in the colon of the OB group (Figure 3). Intestinal pro-inflammatory cytokines, such as IL-8 and TNF-α, have been shown to increase intestinal permeability through the dysregulation of tight junction proteins [35,36]. NF-κB is an important transcription factor involved in the regulation of inflammation and immune responses [37].…”

Section: Discussionmentioning

confidence: 99%

Effects of Oat Bran on Nutrient Digestibility, Intestinal Microbiota, and Inflammatory Responses in the Hindgut of Growing Pigs

Bai

Jiang

et al. 2018

IJMS

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Oat bran has drawn great attention within human research for its potential role in improving gut health. However, research regarding the impact of oat bran on nutrient utilization and intestinal functions in pigs is limited. The purpose of this study was to investigate the effects of oat bran on nutrient digestibility, intestinal microbiota, and inflammatory responses in the hindgut of growing pigs. Twenty-six growing pigs were fed either a basal diet (CON) or a basal diet supplemented with 10% oat bran (OB) within a 28 day feeding trial. Results showed that digestibility of dietary gross energy, dry matter, organic matter, and crude protein were lower in the OB group compared to the CON group on day 14, but no differences were observed between the two groups on day 28. In the colon, the relative abundance of operational taxonomic units (OTUs) associated with Prevotella, Butyricicoccus, and Catenibacterium were higher, while those associated with Coprococcus and Desulfovibrio were lower in the OB group compared to the CON group. Oat bran decreased mRNA expression of caecal interleukin-8 (IL-8), as well as colonic IL-8, nuclear factor-κB (NF-κB), and tumor necrosis factor-α (TNF-α) of the pigs. In summary, oat bran treatment for 28 day did not affect dietary nutrient digestibility, but promoted the growth of cellulolytic bacteria and ameliorated inflammatory reactions in the hindgut of growing pigs.

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Section: Discussionmentioning

confidence: 99%

Effects of Oat Bran on Nutrient Digestibility, Intestinal Microbiota, and Inflammatory Responses in the Hindgut of Growing Pigs

Bai

Jiang

et al. 2018

IJMS

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“…(Chinese chives) have been characterized [44]. Several in vitro and in vivo studies witnessed the immunomodulatory [45][46][47], prebiotic [48], antiviral [49], and gastroprotective [50] effects of allium poly-and oligosaccharides. Lee et al [46] reported the influenza A virus inhibitory activity of the fructan from A. fistulosum in an animal model and it was suggested to be mediated by host immune functions since the polysaccharide did not show any direct inhibitory effect on the virus replication in vitro.…”

Section: Fructans and Fructo-oligosaccharidesmentioning

confidence: 99%

“…In the case of layers, most of the studies found no significant changes in performance when layer diets were supplemented with alliums [65][66][67][68]. Some researchers suggested that well-nourished healthy poultry reared under clean and ideal conditions, often do not respond to growth-promoting supplements, while the stressed or challenged birds may give better results with the same supplements [49,66,67,[69][70][71][72]. Intriguingly, Ao et al [66] indicated garlic supplementation could increase growth performance in broilers by reducing the concentration of cortisol, the stress hormone.…”

Section: Effects On Growth Performancementioning

confidence: 99%

“…In addition, the dietary supplementation of A. hookeri significantly increased expressions of tight junction (TJ) proteins [junctional adhesion molecule (JAM), occludin, and zonula occludens 1 (ZO1)] and intestinal mucin 2 (MUC2). These proteins play crucial roles in the regulation of intestinal permeability and barrier function [49].…”

Section: Effects On Immune Responsementioning

confidence: 99%

“…Lee et al [49] reported that the dietary supplementation of A. hookeri promoted gut integrity and enhanced innate immunity during an immunological stress induced by lipopolysaccharide (LPS) in young broiler chicken. They observed decreased levels of alpha-1-acid glycoprotein (α-1-AGP), a marker for systemic non-specific inflammation or gut barrier health.…”

Section: Effects On Immune Responsementioning

confidence: 99%

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The Genus Allium as Poultry Feed Additive: A Review

Kothari

Lee

Niu

et al. 2019

Animals

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The genus Allium, belonging to the family Amaryllidaceae has been known since ancient times for their therapeutic potentials. As the number of multi-drug resistant infections has increased due to in-feed antibiotic usage in poultry, the relevance of alliums as feed additives has been critically assessed. Garlic and the other Allium species, such as onions, leek, shallot, scallion, and chives, have been characterized to contain a plethora of bioactive compounds such as organosulfur compounds, polyphenols, saponins, fructans, and fructo-oligosaccharides. Consequently, alliums have been validated to confer antioxidant, antibacterial, antiviral, immunostimulatory, gut homeostasis, and lipid- as well as cholesterol-lowering properties in poultry. This review intends to summarize recent progress on the use of edible alliums as poultry feed additives, their beneficial effects, and the underlying mechanisms of their involvement in poultry nutrition. Perspectives for future research and limitations are also briefly discussed.

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Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

et al. 2021

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BACKGROUND The disadvantages associated with the use of synthetic additives in animal production could threaten human and animal health, and the safety of animal‐derived foods. This study assessed the growth performance, blood chemistry, immune indices, selected caeca bacterial population, muscle antioxidant enzyme activities, and meat quality in broiler chickens fed diet supplemented with antibiotic (70% oxytetracycline +30% neomycin), tert‐butylhydroxytoluene or onion leaf powder (OLP). One day old Ross 308 chicks (n = 240) were assigned randomly to either D‐1, control diet (CD) without additives; D‐2, CD + 0.3 g kg−1 antibiotic +0.15 g kg−1 tert‐butylhydroxytoluene; D‐3, CD + 2.5 g kg−1 OLP; or D‐4, CD + 5 g kg−1 OLP for 42 days. RESULTS The D‐2 and D‐4 diets improved (P < 0.05) bodyweight gain and feed efficiency in broilers. Platelet and cecal Lactobacillus spp. counts were higher (P < 0.05) whereas muscle cholesterol was lower (P < 0.05) in the OLP‐supplemented birds. Supplemented birds had higher (P < 0.01) splenic interleukin‐10 and lower (P < 0.01) splenic tumor necrosis factor‐α, immunoglobulin A, cecal E. coli and C. perfringens counts compared with the D‐1 birds. The D‐4 birds had the least (P < 0.05) splenic interleukin‐1β. Dietary supplements increased (P < 0.05) catalase, glutathione peroxidase, and total antioxidant capacity, and lowered (P < 0.05) drip loss, malondialdehyde and carbonyl content in breast meat. CONCLUSION Dietary supplementation of 5 g kg−1 OLP exerted antimicrobial, immunomodulatory, and antioxidant effects that were comparable to those of antibiotics and tert‐butylhydroxytoluene in broiler chickens. © 2021 Society of Chemical Industry.

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RETRACTED: Dietary Allium hookeri reduces inflammatory response and increases expression of intestinal tight junction proteins in LPS-induced young broiler chicken

Cited by 50 publications

References 25 publications

Effects of Oat Bran on Nutrient Digestibility, Intestinal Microbiota, and Inflammatory Responses in the Hindgut of Growing Pigs

Effects of Oat Bran on Nutrient Digestibility, Intestinal Microbiota, and Inflammatory Responses in the Hindgut of Growing Pigs

The Genus Allium as Poultry Feed Additive: A Review

Onion leaf and synthetic additives in broiler diet: impact on splenic cytokines, serum immunoglobulins, cecal bacterial population, and muscle antioxidant status

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