RETRACTED: Curcumin alleviates lipopolysaccharide-induced neuroinflammation in fetal mouse brain

Chen, Hongyan; Tang, Yingli; Han-yan, Wang; Chen, Weibing; Jiang, Hong

doi:10.3233/rnn-180834

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…The protective effects of curcumin in bacterial infections may primarily be due to its ability in modulating host immune response to bacterial virulence factors such as LipoPolySaccharide (LPS). In fact, by using animal models, it has been proven that curcumin was able to reverse the release of several pro-inflammatory cytokine after administration of LPS to pregnant mice [97].…”

Section: Curcumin As Potential Treatment Of Viral and Bacterial Infectionsmentioning

confidence: 99%

The Multifaced Actions of Curcumin in Pregnancy Outcome

et al. 2021

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Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is considered quite safe as it does not have serious side effects. Its functions as an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, and anti-diabetic compound are already known and widely demonstrated. There are numerous studies concerning its effects on various human pathologies including cancer, diabetes and arthritis while the studies on curcumin during pregnancy have been performed only in animal models. Data concerning the role of curcumin as anti-inflammatory compound suggest a possible use of curcumin in managing pregnancy complications such as Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), and exposure to toxic agents and pathogens. The aim of this review is to present data to support the possible use of curcumin in clinical trials on human gestation complications.

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Section: Curcumin As Potential Treatment Of Viral and Bacterial Infectionsmentioning

confidence: 99%

The Multifaced Actions of Curcumin in Pregnancy Outcome

et al. 2021

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“…99 Curcumin, a polyphenol extracted from the plant Curcuma Longa, is an antioxidant reactive oxygen species scavenger, with reported anti-inflammatory and neuroprotective properties following antenatal or postnatal administration in preclinical studies. 100,101 Experiments in vitro and animal studies have shown that curcumin can influence several signaling pathways, such as those regulated by NF-κB, Akt, toll-like receptor (TLR-4), growth factors, and nuclear factor erythroid-2-related factor 2 (Nrf2), among others. For example, preclinical studies showed that curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through the induction of Nrf2 and heme oxygenase-1, 102 protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferatoractivated receptor-γ function, 103 suppresses apoptosis and inflammation in hypoxia/reperfusion-exposed neurons via Wnt signaling pathway, 104 protects preoligodendrocytes against the toxicity of LPS-activated microglia via inhibiting the expression of inducible nitric oxide synthase and NADPH oxidase subunits in microglia, 105 and attenuates inflammatory response via TLR-4.…”

Section: Dietary Supplementsmentioning

confidence: 99%

Pharmacological Neuroprotection of the Preterm Brain: Current Evidence and Perspectives

Siahanidou

Spiliopoulou

2020

Am J Perinatol

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Despite improvements in viability, the long-term neurodevelopmental outcomes of preterm babies remain serious concern as a significant percentage of these infants develop neurological and/or intellectual impairment, and they are also at increased risk of psychiatric illnesses later in life. The current challenge is to develop neuroprotective approaches to improve adverse outcomes in preterm survivors. The purpose of this review was to provide an overview of the current evidence on pharmacological agents targeting the neuroprotection of the preterm brain. Among them, magnesium sulfate, given antenatally to pregnant women with imminent preterm birth before 30 to 34 weeks of gestation, as well as caffeine administered to preterm infants after birth, exhibited neuroprotective effects for human preterm brain. Erythropoietin treatment of preterm infants did not result in neuroprotection at 2 years of age in two out of three published large randomized controlled trials; however, long-term follow-up of these infants is needed to come to definite conclusions. Further studies are also required to assess whether melatonin, neurosteroids, inhaled nitric oxide, allopurinol, or dietary supplements (omega-3 fatty acids, choline, curcumin, etc.) could be implemented as neuroprotectants in clinical practice. Furthermore, other pharmacological agents showing promising signs of neuroprotective efficacy in preclinical studies (growth factors, hyaluronidase inhibitors or treatment, antidiabetic drugs, cannabidiol, histamine-H3 receptor antagonists, etc.), as well as stem cell- or exosomal-based therapies and nanomedicine, may prove useful in the future as potential neuroprotective approaches for human preterm brain. Key Points

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“…The causes of cerebral palsy in term and preterm babies are different. Compared with other models, such as the preterm brain damage model [13,14], the infectious preterm chorioamnionitis model [15], and the LPS induced maternal systematic to fetal inflammation model [16][17][18][19][20][21][22], our mouse model was only designed to mimic increasing inflammation at term. It is critical to model asymptomatic BV-like vaginal inflammation to intrauterine inflammation following uterine contractions-like ischemic reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Amniotic LPS-Induced Apoptosis in the Fetal Brain Is Suppressed by Vaginal LPS Preconditioning but Is Promoted by Continuous Ischemic Reperfusion

Dong

Kimura

Yaegashi

2022

IJMS

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Chorioamnionitis (CAM) is an increasingly common disease affecting pregnant women which derives from bacterial vaginosis. In different clinical cases, it has been shown that CAM can cause multiple risk factors for fetal brain damage, such as infection, and intra-uterine asphyxia. However, the molecular mechanism remains unknown. In this study, we established a novel CAM mouse model by exposing pregnant mice to a combination of three risk factors: vaginal lipopolysaccharides (LPS), amniotic LPS, and ischemic reperfusion. We found amniotic LPS caused Parkinson’s disease-like fetal brain damage, in a dose and time-dependent manner. Moreover, the mechanism of this fetal brain damage is apoptosis induced by amniotic LPS but it was inhibited by being pretreated with a vaginal LPS challenge before amniotic LPS injection. In contrast, amniotic LPS with continuous ischemic reperfusion caused a higher level of apoptotic cell death than amniotic LPS alone. In particular, a potential neuroprotective biomarker phosphorylation (p)-CREB (ser133) appeared in only vaginal LPS preconditioned before amniotic LPS, whereas ischemic reperfusion triggered IKK phosphorylation after amniotic LPS. Despite the need for many future investigations, this study also discussed a developed understanding of the molecular mechanism of how these phenotypes occurred.

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RETRACTED: Curcumin alleviates lipopolysaccharide-induced neuroinflammation in fetal mouse brain

Cited by 6 publications

References 31 publications

The Multifaced Actions of Curcumin in Pregnancy Outcome

The Multifaced Actions of Curcumin in Pregnancy Outcome

Pharmacological Neuroprotection of the Preterm Brain: Current Evidence and Perspectives

Amniotic LPS-Induced Apoptosis in the Fetal Brain Is Suppressed by Vaginal LPS Preconditioning but Is Promoted by Continuous Ischemic Reperfusion

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