RETRACTED: Controlled delivery of ketamine from reduced graphene oxide hydrogel for neuropathic pain: In vitro and in vivo studies

Wang, Rui; Gan, Jianhui; Li, Renhu; Duan, Junfeng; Zhou, Jianjun; Lv, Miaomiao; Qi, Rongqin

doi:10.1016/j.jddst.2020.101964

Cited by 13 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stretching vibration peaks of O–H, C=O, the residual sp 2 carbon peak, and the tertiary carbon C–OH peak are located at 3420, 1730, 1624, and 1392 cm −1 in the GO spectrum, respectively. The alkoxy and epoxy carbons were responsible for the maxima at 1226 and 1079 cm −1 , respectively (Wang et al ., 2020; Yusoff et al ., 2022). The majority of the oxygen‐containing groups were eliminated, and the peaks of these functional groups were considerably diminished, according to the FTIR spectra of rGO/TiO 2 .…”

Section: Resultsmentioning

confidence: 99%

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

Yan,

Lin,

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

SummaryThe rGO/TiO2 nanocomposite photocatalyst was synthesised using the sol–gel‐irradiation way to efficiently remove deoxynivalenol (DON) for the grains product's safety and quality. With the nanosize effect of irradiation, the photocatalyst has a smaller average grain size, preventing the recombination of electrons and holes. Moreover, based on UV–Vis DRS study, rGO/TiO2 could utilise visible light and have a broader response range to light. Furthermore, to the application, the photocatalyst rGO/TiO2 with 30 KGy irradiation dosage had an 80.32 ± 4.41% photocatalytic degradation rate of DON. Compared to the photocatalyst without irradiation, there was a 9.98% increase in the degradation rate. This result provided an excellent candidate photocatalyst for the removal of DON and also promoted the development of photocatalysis applications.

show abstract

Section: Resultsmentioning

confidence: 99%

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

Yan,

Lin,

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Results of the tail-flick test and readings from an analgesiometer led them to determine a significant analgesic effect ( p < 0.01) maintained for 24 h with a peak effect at 8 h and a response time on the test 5.72 s vs. a basal time of 2.44 s. The compound did not produce irritation when tested on rabbit skin. It prevented the secondary effects of intravenous, nasal, or oral administration, so it is a potential option for treating neuropathic pain [ 108 ].…”

Section: Animal Models and Their Application In Distinct Fields Of Cu...mentioning

confidence: 99%

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Domínguez-Oliva

Hernández-Ávalos

Martı́nez-Burnes

et al. 2023

Animals

View full text Add to dashboard Cite

Animal research is considered a key element in advance of biomedical science. Although its use is controversial and raises ethical challenges, the contribution of animal models in medicine is essential for understanding the physiopathology and novel treatment alternatives for several animal and human diseases. Current pandemics’ pathology, such as the 2019 Coronavirus disease, has been studied in primate, rodent, and porcine models to recognize infection routes and develop therapeutic protocols. Worldwide issues such as diabetes, obesity, neurological disorders, pain, rehabilitation medicine, and surgical techniques require studying the process in different animal species before testing them on humans. Due to their relevance, this article aims to discuss the importance of animal models in diverse lines of biomedical research by analyzing the contributions of the various species utilized in science over the past five years about key topics concerning human and animal health.

show abstract

“…Ketamine is typically administered intravenously, and its use is associated with several side effects, including dissociative effects, hallucinations, and changes in blood pressure and heart rate. Therefore, topical formulations may be a great alternative [52]. Wang et al [52] developed a ketamine-loaded PL F127 stabilized reduced graphene oxide hydrogel for sustained transdermal drug delivery.…”

Section: Other Substancesmentioning

confidence: 99%

Recent Progress in Gels for Neuropathic Pain

Pușcașu,

Zanfirescu,

Negreș

2023

Gels

View full text Add to dashboard Cite

Neuropathic pain is a complex and debilitating condition that affects millions of people worldwide. While several treatment options are available, they often have limited efficacy and are associated with adverse effects. In recent years, gels have emerged as a promising option for the treatment of neuropathic pain. Inclusion of various nanocarriers, such as cubosomes and niosomes, into gels results in pharmaceutical forms with higher drug stability and increased drug penetration into tissues compared to products currently marketed for the treatment of neuropathic pain. Furthermore, these compounds usually provide sustained drug release and are biocompatible and biodegradable, which makes them a safe option for drug delivery. The purpose of this narrative review was to provide a comprehensive analysis of the current state of the field and identify potential directions for future research in the development of effective and safe gels for the treatment of neuropathic pain, ultimately improving the quality of life for patients suffering from neuropathic pain.

show abstract

RETRACTED: Controlled delivery of ketamine from reduced graphene oxide hydrogel for neuropathic pain: In vitro and in vivo studies

Cited by 13 publications

References 57 publications

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Recent Progress in Gels for Neuropathic Pain

Contact Info

Product

Resources

About

RETRACTED: Controlled delivery of ketamine from reduced graphene oxide hydrogel for neuropathic pain: In vitro and in vivo studies

Cited by 13 publications

References 57 publications

A nano photocatalyst rGO/TiO2 modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

A nano photocatalyst rGO/TiO2 modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Recent Progress in Gels for Neuropathic Pain

Contact Info

Product

Resources

About

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products

A nano photocatalyst rGO/TiO₂ modified by sol–gel‐irradiation and its degradation of deoxynivalenol in liquid products