RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial

Badawy, Ahmed; Elnashar, Abubaker; Totongy, Mohamed

doi:10.1016/j.fertnstert.2008.06.013

Cited by 59 publications

(56 citation statements)

References 32 publications

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“…Results from studies comparing the number of follicles are heterogeneous, and no correlation with multiple pregnancy rates has been reported [26][27][28][29][30] . We found no difference in the multiple pregnancy rates, confirming the results reported in the literature [25,[28][29][30] . The AMIGOS trial showed comparable multiple gestation rates with CC or letrozole (9 vs. 13%, p = 0.44), while both were significantly lower than gonadotropins [22] .…”

Section: Discussionsupporting

confidence: 92%

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Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination

Hachem

Antaki²,

Sylvestre³

et al. 2016

Gynecol Obstet Invest

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Aim: To compare clomiphene citrate (CC) and letrozole for ovarian stimulation (OS) in therapeutic donor sperm insemination (TDI) cycles. Methods: Retrospective cohort study between January 2011 and June 2014 at a University-affiliated private IVF clinic in Montreal, Canada. 257 normo-ovulatory women ≤40 years of age with no history of infertility undergoing 590 TDI cycles in the absence of a male partner (single women and same-sex couples) or azoospermia were included. Patients received 100 mg CC daily (145 women, 321 cycles) or letrozole 5 mg daily (112 women, 269 cycles), from days 3 to 7. Only the first 3 cycles were included per patient. Our main outcome measure was cumulative live birth rates (LBR). Results: Baseline characteristics were comparable between the 2 groups. There were no differences in LBR per cycle (16.5% (53/321) vs. 11.5% (31/269), p = 0.08) and cumulative LBR (36.6% (53/145) vs. 27.7% (31/112), p = 0.13), between CC and letrozole, respectively. Multiple pregnancy rate (11.6% (8/69) vs. 8.7% (4/46), p = 0.6) and miscarriage rate (21.7 vs. 21.7%, p = 1) were also comparable between CC and letrozole, respectively. Conclusion: In normo-ovulatory women undergoing TDI, OS with CC or letrozole resulted in similar live birth and twin pregnancy rates.

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Section: Discussionsupporting

confidence: 92%

“…Our CPR were also comparable between the 2 groups, in accordance with 5 RCTs comparing the 2 drugs in couples with unexplained infertility [22,[25][26][27][28] . Only one study [29] reported significantly higher CPR with letrozole, but the difference could be explained by the very low CPR found with CC (23.07 vs. 10.68%, p < 0.001).…”

Section: Discussionsupporting

confidence: 87%

Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination

Hachem

Antaki²,

Sylvestre³

et al. 2016

Gynecol Obstet Invest

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“…The concept of using aromatase inhibitors (AIs) as a new method of controlled ovarian stimulation has been extensively investigated by several research groups in the past few years [2,3,4,5]. AIs have less antiestrogenic effects on the endometrium, which can be advantageous to keeping the endometrium in optimal condition for maintaining pregnancy [6].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women

Wang

Zheng²

2014

Gynecol Obstet Invest

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Aims: To determine the efficacy of letrozole alone or with recombinant follicle-stimulating hormone (rFSH) for ovarian induction in anovulatory women. Methods: A total of 322 patients undergoing intrauterine insemination (IUI) were included in this retrospective study. Letrozole (2.5 or 5.0 mg) was administered from days 5 to 9 of menses, alone or followed with rFSH started on day 9 until the day of human chorionic gonadotropin administration. A single IUI was performed 24 h after ovulation. Results: The number of follicles, endometrial thickness and serum estradiol levels were significantly higher in the letrozole + rFSH groups than in the letrozole-alone groups (p < 0.05), but no significant difference was found between the two doses of letrozole, whether alone or with rFSH. Women treated with 5.0 mg/day of letrozole + rFSH required a total dose of rFSH similar to women treated with 2.5 mg/day of letrozole + rFSH (230.77 ± 118.29 vs. 258.55 ± 130.13 IU, respectively; p = 0.205). There was no significant difference in pregnancy rates between the two doses of letrozole, whether alone or with rFSH. Conclusion: Treatment with letrozole + rFSH was more efficacious than letrozole alone for pregnancy in the IUI program; however, the effect of 5.0 mg/day of letrozole versus 2.5 mg/day of letrozole on ovulation was equivalent, regardless of whether rFSH was used.

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“…Treatment with ovulation-stimulating fertility drugs causes recruitment and maturation of multiple ovarian follicles, temporarily elevating estrogen; in women treated with clomiphene citrate (CC), the peak serum levels of estrogen are two-to threefold higher than normal (average: 200 pg/mL at peak) (3,4), and peak levels are even higher in women who undergo in vitro fertilization (IVF) treatment, which typically involves the use of folliclestimulating hormone (FSH)-containing drugs (5,6). If pregnancy results, the supernumerary ovarian corpora lutea produce both estrogen and progesterone and raise the levels far above normal in the first 9 weeks (7,8).…”

Section: J Natl Cancer Inst 2012;104:1021-1027mentioning

confidence: 99%

Fertility Drugs and Young-Onset Breast Cancer: Results From the Two Sister Study

Fei¹,

DeRoo²,

Sandler³

et al. 2012

JNCI: Journal of the National Cancer Institute

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RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial

Cited by 59 publications

References 32 publications

Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination

Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination

A Comparison of the Efficacy of Two Doses of Letrozole Alone or with Continuous Recombinant Follicle-Stimulating Hormone for Ovulation Induction in Anovulatory Women

Fertility Drugs and Young-Onset Breast Cancer: Results From the Two Sister Study

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