RETRACTED: Clinical transplantation of a tissue-engineered airway

Macchiarini, Paolo; Jungebluth, Philipp; Go, Tetsuhiko; Asnaghi, M. Adelaide; Rees, Len; Cogan, Tristan A; Dodson, A; Martorell, Jaume; Bellini, Silvia; Parnigotto, Pier Paolo; Dickinson, Sally C.; Hollander, Anthony P.; Mantero, Sara; Conconi, Maria Teresa; Birchall, Martin A.

doi:10.1016/s0140-6736(08)61598-6

Cited by 1,365 publications

(1,084 citation statements)

References 28 publications

(34 reference statements)

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“…Numerous labs are characterizing adult lung stem cells with the long-term aim of manipulating their behavior for therapeutic purposes. One successful clinical example of stem cell therapy for the lung has been reported: transplantation of a decellularized trachea reseeded with the patient's own bronchial epithelial cells (Macchiarini et al, 2008). Similar techniques have been used to obtain bioengineered rat lungs, which were able to function for up to 6 hours after transplantation (Ott et al, 2010;Petersen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The building blocks of mammalian lung development

Rawlins

2010

Developmental Dynamics

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Progress has recently been made in identifying progenitor cell populations in the embryonic lung. Some progenitor cell types have been definitively identified by lineage-tracing studies. However, others are not as well characterized and their existence is inferred on the basis of lung morphology, or mutant phenotypes. Here, I focus on lung development after the specification of the initial lung primordium. The evidence for various lung embryonic progenitor cell types is discussed and future experiments are suggested. The regulation of progenitor proliferation in the embryonic lung, and its coordinate control with morphogenesis, is also discussed. In addition, the relationship between embryonic and adult lung progenitors is considered. Developmental Dynamics 240:463-476,

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Section: Introductionmentioning

confidence: 99%

The building blocks of mammalian lung development

Rawlins

2010

Developmental Dynamics

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“…The first transplant of this artificially created airway has already taken place successfully 9 . This has significant implications for both the pediatric and adult populations but it is important to remember that early detection of these cases(i.e.…”

Section: Discussionmentioning

confidence: 99%

Congenital high airways obstruction syndrome – first and second trimester diagnosis

Paoletti

Robertson

2014

Australas J Ultrason Med

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Congenital High Airways Obstruction Syndrome (CHAOS) is a rare condition associated with high fetal or neonatal mortality. Prenatal diagnosis in the second trimester is made by the typical ultrasound features of large echogenic lungs, a flattened or inverted diaphragm, and fetal ascites or hydrops. We present two cases diagnosed at our institution; one in the second trimester, and a first trimester diagnosis. To the best of our knowledge, first trimester diagnosis of CHAOS has not been previously reported.

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“…Encouraging results have been obtained in mouse and pig models with the development of a streamlined process in which autologous epithelial and mesenchimal stem-cell-derived condrocytes are seeded onto a decellularized donor tracheal scaffold and matured in a novel bioreactor system [44,45]. The absence of an immunological response to this tracheal graft observed in the animal model has promoted the implantation of a tissue engineered tracheal construct in the human for airway reconstruction [44,45].…”

Section: Tracheal Transplantationmentioning

confidence: 99%

Tracheal surgery

D’Andrilli

Rendina

Venuta

2016

Monaldi Arch Chest Dis

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Surgical resection and reconstruction of the trachea can be performed both for benign and malignant diseases. The main indications for surgery include inflammatory (generally post-intubation), congenital or post-traumatic stenoses, degenerative lesions, benign or malignant neoplasms. Success can be pursued only by accurate patient selection and timing, meticulous surgical techniques, careful follow up and, when required, multidisciplinary cooperation. Although surgical resection has now become part of our surgical practice, other treatment modalities are approaching a new clinical application era, in particular tracheal transplantation and bioengineering. These new techniques will certainly offer, in the near future, improved chances to treat difficult cases.

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RETRACTED: Clinical transplantation of a tissue-engineered airway

Cited by 1,365 publications

References 28 publications

The building blocks of mammalian lung development

The building blocks of mammalian lung development

Congenital high airways obstruction syndrome – first and second trimester diagnosis

Tracheal surgery

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