Abstract:Aldehyde oxidase (AO) and xanthine oxidoreductase (XOR) are molybdo-flavoenzymes (MFEs) involved in the oxidation of hundreds of many xenobiotic compounds of which are drugs and environmental pollutants. Mutations in the XOR and molybdenum cofactor sulfurase (MCS) genes result in a deficiency of XOR or dual AO/XOR deficiency respectively. At present despite AO and XOR being classed as detoxification enzymes the definitive experimental proof of this has not been assessed in any animal thus far. The aim of this … Show more
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