RETRACTED ARTICLE: The Risk of Prostate Cancer in Pilots: A Meta-Analysis

Raslau, David; Summerfield, Douglas T.; Dabrh, Abd Moain Abu; Steinkraus, Lawrence W.; Murad, M. Hassan

doi:10.3357/amhp.4075.2015

Cited by 6 publications

(6 citation statements)

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“…Shift work as a possible cause of prostate cancer has been reviewed thoroughly, but results were inconclusive [47–55]. Several mechanisms are proposed to explain the association of prostate cancer and shift workers.…”

Section: Discussionmentioning

confidence: 99%

Occupational Risk Factors for Prostate Cancer: A Meta-analysis

Krstev

Knutsson

2019

J Cancer Prev

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Prostate cancer is the second most common cancer in men worldwide. There are many occupational factors that have been suggested to cause prostate cancer. Our aim was to evaluate the evidence for causality by a literature review of occupational factors. We searched literature in Medline and SCOPUS from 1966 to June 30, 2015 to identify occupational risk factors for prostate cancer. The following risk factors were selected: farmers/agricultural workers, pesticides – whole group, and separately organophosphate and organochlorine pesticides, carbamates and triazines, cadmium, chromium, cutting fluids, acrylonitrile, rubber manufacturing, whole body vibration, shift work, flight personnel, ionizing radiation, and occupational physical activity. For each factor a literature search was performed and presented as meta-analysis of relative risk and heterogeneity (Q and I 2 index). A total of 168 original studies met the inclusion criteria with 90,688 prostate cancer cases. Significantly increased risks were observed for the following occupational exposures: pesticides (metaRR = 1.15, 95% confidence interval [CI] = 1.01–1.32; I 2 = 84%), and specifically group of organochlorine pesticides (meta relative risk [metaRR] = 1.08, 95% CI = 1.03–1.14; I 2 = 0%), chromium (metaRR = 1.19, 95% CI = 1.07–1.34; I 2 = 31%), shift work (metaRR = 1.25, 95% CI = 1.05–1.49; I 2 = 78%) and pilots (metaRR = 1.41, 95% CI = 1.02–1.94; I 2 = 63%) and occupational physical activity in cohort studies (metaRR = 0.87, 95% CI = 0.81–0.94; I 2 = 0%). The literature review supports a causal association for a few of the previously suggested factors.

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Section: Discussionmentioning

confidence: 99%

Occupational Risk Factors for Prostate Cancer: A Meta-analysis

Krstev

Knutsson

2019

J Cancer Prev

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“…Ассоциировано с повышенным риском смерти от РПЖ [19] Гонорея Достоверная корреляция с увеличением выявления РПЖ [20] Работа по ночам Повышенный риск выявления РПЖ [21] Профессиональная лучевая нагрузка (пилоты авиации) Повышенный риск выявления РПЖ [22] Активные курильщики Повышение риска смерти от РПЖ [23] Вазэктомия Не ассоциирована с повышением риска возникновения РПЖ [24] Ацетилсалициловая кислота и нестероидные противовоспалительные препараты Разноречивые данные о влиянии приема ацетилсалициловой кислоты и нестероидные противовоспалительные препараты на риск возникновения РПЖ [25,26] Ультрафиолетовое излучение Уменьшает риск возникновения РПЖ [27] Циркумцизия Уменьшает риск возникновения РПЖ [28] Частота эякуляции (≥21 раз в месяц по сравнению с 4-7 раз в месяц) Частая эякуляция способствует снижению риска возникновения РПЖ на 20% [29] N -регионарные ЛУ…”

Section: облысениеunclassified

Prostate cancer

et al. 2021

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Prostate cancer (RPP) is a malignant neoplasm that arises from the epithelium of the prostate gland gland (PJ). рак предстательной железы; клинические рекомендацииThethiology and pathogenesis of this disease remain poorly studied. Many studies are aimed at studying diet, food, hormonal impact, as well as infections in the etiology of the RLPG. The prevalence of RPL depends on ethnic and geographical features. The highest incidence of African Americans living in the United States (60% higher than that of white Americans), the least high - in the Chinese living in China [1]. In addition to racial features, the risk factors of the RPG are considering the genetic predisposition, the age of men and nutritional features. The probability of developing a PJ tumor in a man who has one of the closest relatives of the first degree of kinship (father or brother) sick of the RLPG, is 1.8 times higher than in the population. If two relatives were sick or more (father and brother or both brothers), the risk of RPG increases in 5.51 and 7.71 times, respectively [2, 3]. African Americans have an increased risk of identifying RPG, as well as a greater probability of detecting aggressive RPG [4]. Also, the risk of RLPG is rising in men who use a large amount of animal fats [5].

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“…Epidemiological evidence so far points to the connections between PCa and CRD. Meta-analyses on the health outcomes of airplane pilots [ 18 , 19 ] and studies on female night shift nurses [ 20 ] have demonstrated the contribution of CRD (due to jetlag or night shift work) to both prostate and breast cancer [ 21 ]. Sleep disruption and light-induced melatonin suppression, both related outcomes of CRD, are associated with an increased risk for advanced PCa [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm Disruption as a Contributor to Racial Disparities in Prostate Cancer

Dasari

Archer

Mohamed

et al. 2022

Cancers

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In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer.

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RETRACTED ARTICLE: The Risk of Prostate Cancer in Pilots: A Meta-Analysis

Abstract: Pilots are at least twice as likely to develop prostate cancer compared to the general population. The implications of these findings are important considering the high prevalence of prostate cancer and the large number of pilots in the workforce.

Cited by 6 publications

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Occupational Risk Factors for Prostate Cancer: A Meta-analysis

Occupational Risk Factors for Prostate Cancer: A Meta-analysis

Prostate cancer

Circadian Rhythm Disruption as a Contributor to Racial Disparities in Prostate Cancer

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