RETRACTED ARTICLE: The Lnc LINC00461/miR-30a-5p facilitates progression and malignancy in non-small cell lung cancer via regulating ZEB2

Li, Xin; Liu, Jinghao; Liu, Minghui; Xia, Chunqiu

doi:10.1080/15384101.2020.1731946

Cited by 19 publications

(10 citation statements)

References 45 publications

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“…It has been increasingly evidenced that there is a novel and extensive interaction network involving ceRNAs ( 27 , 28 ), where lncRNAs regulate miRNAs by binding their target sites on protein-coding mRNA molecules. For example, LINC00461 functions as a ceRNA to regulate ZEB2 expression by sponging miR-30a-5p to promote progression and malignancy in non-small cell lung cancer ( 29 ), SNHG15 functions as a ceRNA to promote KLF9-mediated proliferation by acting as a decoy for miR-141-3p in nasopharyngeal carcinoma ( 30 ), and DANCR promotes osteosarcoma migration and invasion by acting as a ceRNA that sponges miR-149 to regulate MSI2 expression ( 31 ). In this study, it was discovered that LINC00857 was located largely in the cytoplasm of PC cells, and functioned as a sponge for miR-150-5p.…”

Section: Discussionmentioning

confidence: 99%

m6A-Mediated Upregulation of LINC00857 Promotes Pancreatic Cancer Tumorigenesis by Regulating the miR-150-5p/E2F3 Axis

Meng

Deng

et al. 2021

Front. Oncol.

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The mortality and morbidity rates of pancreatic cancer (PC) have been increasing over the past two decades. Recent evidence indicates that long non-coding RNAs (lncRNAs) are usually dysregulated in the tumorigenesis and progression of PC. In the present study, we showed that the expression of LINC00857 was upregulated in PC and associated with poor prognosis based on the Gene Expression Profiling Interactive Analysis (GEPIA) database and validated in our PC tissues and cell lines. N6-Methyladenosine (m6A) was highly enriched within LINC00857 and enhanced its RNA stability. Knockdown of LINC00857 remarkably inhibited the proliferation and promoted the apoptosis of PC cells. Then, by using bioinformation analysis and verified experiments, we identified that LINC00857 functioned as a competing endogenous RNA (ceRNA) for sponging miR-150-5p, leading to the upregulation of its target E2F3 in PC cells. Taken above, our study revealed a potential ceRNA regulatory pathway in which LINC00857 modulates E2F3 expression by binding to miR-150-5p, ultimately promoting tumorigenesis in PC. LINC00857/miR-150-5p/E2F3 regulatory axis may be taken as an alternative therapeutic target for treating PC.

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Section: Discussionmentioning

confidence: 99%

m6A-Mediated Upregulation of LINC00857 Promotes Pancreatic Cancer Tumorigenesis by Regulating the miR-150-5p/E2F3 Axis

Meng

Deng

et al. 2021

Front. Oncol.

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“…The miR-30a-5p was confirmed by bioinformatics analyses and was further verified by in the present study. MiR-30a-5p has been studied in numerous diseases, such as cholangiocarcinoma 42 , osteoarthritis 43 , lung cancer [44][45][46] , and colorectal cancer 47,48 . Furthermore, miR-30a-5p interacts with several ncRNAs, such as LINC00461 43,44 , NORAD 45 , DLEU2 46 , LIN28B 47 , and FEZF1-AS1 48 .…”

Section: Discussionmentioning

confidence: 99%

“…MiR-30a-5p has been studied in numerous diseases, such as cholangiocarcinoma 42 , osteoarthritis 43 , lung cancer [44][45][46] , and colorectal cancer 47,48 . Furthermore, miR-30a-5p interacts with several ncRNAs, such as LINC00461 43,44 , NORAD 45 , DLEU2 46 , LIN28B 47 , and FEZF1-AS1 48 . Based on experimental results, miR-30a-5p as a negative regulatory agent participated in the progression of renal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…The microRNAs (miRNAs) are 18-25 nucleotide non-coding RNAs, which can regulate the tumorigenesis and progression of many tumors [42][43][44][45][46][47][48][49] . The miRNAs also play a role in the evolution of species, and miR-30a-5p has been reported to play a role in many diseases, including cholangiocarcinoma 42 ; it can also act as a negative regulator, contributing to the evolution of renal carcinomas.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA

et al. 2021

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Objective: Several reports have proposed that lncRNAs, as potential biomarkers, participate in the progression and growth of malignant tumors. HIF1A-AS2 is a novel lncRNA and potential biomarker, involved in the genesis and development of carcinomas. However, the molecular mechanism of HIF1A-AS2 in renal carcinoma is unclear. Methods: The relative expression levels of HIF1A-AS2 and miR-30a-5p were detected using RT-qPCR in renal carcinoma tissues and cell lines. Using loss-of-function and overexpression, the biological effects of HIF1A-AS2 and miR-30a-5p in kidney carcinoma progression were characterized. Dual luciferase reporter gene analysis and Western blot were used to detect the potential mechanism of HIF1A-AS2 in renal carcinomas. Results: HIF1A-AS2 was upregulated in kidney carcinoma tissues when compared with para-carcinoma tissues (P < 0.05). In addition, tumor size, tumor node mestastasis stage and differentiation were identified as being closely associated with HIF1A-AS2 expression (P < 0.05). Knockdown or overexpression of HIF1A-AS2 either restrained or promoted the malignant phenotype and WNT/β-catenin signaling in renal carcinoma cells (P < 0.05). MiR-30a-5p was downregulated in renal cancers and partially reversed HIF1A-AS2 functions in malignant renal tumor cells. HIF1A-AS2 acted as a microRNA sponge that actively regulated the relative expression of SOX4 in sponging miR-30a-5p and subsequently increased the malignant phenotypes of renal carcinomas. HIF1A-AS2 showed a carcinogenic effect and miR-30a-5p acted as an antagonist of the anti-oncogene effects in the pathogenesis of renal carcinomas. Conclusions:The HIF1A-AS2-miR-30a-5p-SOX4 axis was associated with the malignant progression and development of renal carcinoma. The relative expression of HIF1A-AS2 was negatively correlated with the expression of miR-30a-5p, and was closely correlated with SOX4 mRNA levels in renal cancers.

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“…For example, AFAP1-AS1 facilitates triple negative breast cancer through sponging miR-145 11 . LINC00461/miR-30a-5p promotes cell proliferation and migration in NSCLC 12 . Additionally, SPRY4-IT1 accelerates progression of osteosarcoma via interacting with miR-101 13 .…”

Section: Introductionmentioning

confidence: 99%

LncRNA LINC00520 Aggravates Cell Proliferation and Migration in Lung Adenocarcinoma via a Positive Feedback Loop

Huang

Wang

et al. 2021

Preprint

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Background: Lung adenocarcinoma (LUAD) is the most common histological subtype of primary lung cancer. Thus, to figure out the biomarker of diagnosis for LUAD is of great significance. Long non-coding RNAs (lncRNAs) are previously revealed to exert vital effects in numerous cancers. LncRNA long intergenic non-protein coding RNA 520 (LINC00520) served as an oncogene in certain cancers. Therefore, our report was specially designed to probe role of LINC00520 in LUAD. Results: LINC00520 expression was detected by RT-qPCR. Next, function of LINC00520 in LUAD was verified by in vitro loss-of-function experiments. As for LINC00520 regulatory mechanism in LUAD, we conducted pull down, ChIP, RIP, and luciferase reporter assays. We found that LINC00520 was upregulated in LUAD. Additionally, LINC00520 upregulation suggested the poorer prognosis for patients with LUAD. Furthermore, LINC00520 downregulation suppressed LUAD cell proliferation and migration and induced cell apoptosis. Simultaneously, forkhead box P3 (FOXP3) is identified as the transcription factor (TF) to transcriptionally activate LINC00520. Moreover, LINC00520 positively upregulated FOXP3 via sponging miR-3611 in LUAD. Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression could reverse the effect of silenced LINC00520 on proliferative and migratory capabilities in LUAD. Conclusion: This study ﬁrst put forward and proved that lncRNA LINC00520 facilitated cell proliferative and migratory abilities in LUAD through interacting with miR-3611 and targeting FOXP3, which may provide a potential novel insight for treatment of LUAD.

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RETRACTED ARTICLE: The Lnc LINC00461/miR-30a-5p facilitates progression and malignancy in non-small cell lung cancer via regulating ZEB2

Cited by 19 publications

References 45 publications

m6A-Mediated Upregulation of LINC00857 Promotes Pancreatic Cancer Tumorigenesis by Regulating the miR-150-5p/E2F3 Axis

m6A-Mediated Upregulation of LINC00857 Promotes Pancreatic Cancer Tumorigenesis by Regulating the miR-150-5p/E2F3 Axis

LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA

LncRNA LINC00520 Aggravates Cell Proliferation and Migration in Lung Adenocarcinoma via a Positive Feedback Loop

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