RETRACTED ARTICLE: The Consumption of Synbiotic Bread Containing
            <i>Lactobacillus sporogenes</i>
            and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial

Bahmani, Fereshteh; Tajadadi-Ebrahimi, Maryam; Kolahdooz, Fariba; Mazouchi, Marjan; Hadaegh, Haleh; Jamal, Atefeh-Sadat; Mazroii, Navid; Asemi, Shiva; Asemi, Zatollah

doi:10.1080/07315724.2015.1032443

Cited by 80 publications

(85 citation statements)

References 49 publications

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“…Soleimani et al showed that probiotic supplementation for 12 weeks among diabetic hemodialysis patients reduced levels of some inflammation biomarkers as well as markers of oxidative stress such as MDA. In another study, consumption of bread containing a synbiotic bread for 8 weeks by patients with T2DM decreased plasma MDA levels; however, it did not affect plasma total antioxidant capacity, glutathione, or catalase levels . In the study by Suo et al, it was found that a probiotic supplement containing Lactobacillus fermentum ) reduced MDA activity in mice with gastric injury .…”

Section: Discussionmentioning

confidence: 94%

“…Soleimani et al 35 showed that probiotic supplementation for 12 weeks among diabetic hemodialysis patients reduced levels of some inflammation biomarkers as well as markers of oxidative stress such as MDA. In another study, consumption of bread containing 36 In the study by Suo et al, it was found that a probiotic supplement containing Lactobacillus fermentum) reduced MDA activity in mice with gastric injury. 37 Another study indicated that a probiotic supplement enhanced antioxidant efficacy and helped scavenge free radicals.…”

Section: Discussionmentioning

confidence: 95%

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A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kooshki

Tofighiyan

Miri

2019

Hemodialysis International

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Introduction: Among the most important risk factors for cardiovascular disease in hemodialysis patients are high concentrations of serum inflammation markers, lipid profiles, and oxidative stress. The present study aimed to investigate the effects of a synbiotic supplement on serum systemic inflammation, oxidative stress markers, and lipid profile in hemodialysis patients. Methods: Fifty hemodialysis patients were randomly allocated to synbiotic and placebo groups. The synbiotic group received 2 tablets per day of a synbiotic supplement (100 mg) Lactobacillus coagulans and fructo‐oligosaccharides for 8 weeks; whereas the placebo group received a similar appearing placebo. At the beginning and end of the study, 5 mL blood was taken after 12–14 hours of fasting. Findings: Mean values of serum C‐reactive protein (hs‐CRP) and malondialdehyde (MDA) significantly decreased in the synbiotic group at the end compared to the beginning of the study (P = 0.01). This reduction was significant in comparison with changes in the placebo group (P = 0.01). The synbiotic supplement also reduced serum total cholesterol (P = 0.001) and low‐density lipoprotein cholesterol (LDL‐c; P = 0.001) compared to the placebo group. Discussion: The synbiotic supplement used improves serum hs‐CRP and MDA, total cholesterol and LDL‐c in hemodialysis patients, which are known risk factors for cardiovascular disease.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kooshki

Tofighiyan

Miri

2019

Hemodialysis International

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“…In addition, systolic and diastolic blood pressure were also significantly decreased within the synbiotic group. A study by Bahmani et al [35] showed that 120 grams of synbiotic-enriched bread in patients with diabetes mellitus for eight weeks did not have any significant effect on systolic and diastolic blood pressure. The findings of this study are comparable to the present study.…”

Section: Discussionmentioning

confidence: 99%

The effects of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study

Velayati

Kareem

Sedaghat

et al. 2020

Preprint

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Background: Type 2 diabetes is a common metabolic disorder in the world, and it has become a challenge for the health system. Some studies have indicated the desirable effects of synbiotics on metabolic factors in patients with diabetes. Aim: This study aimed to determine the effect of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes mellitus. Methods: In this randomized, double-blind controlled trial, 50 patients with type 2 diabetes randomly allocated to the synbiotic (containing Bacillus coagulans + Lactobacillus rhamnosus + Lactobacillus acidophilus and fructooligosaccharide) or placebo groups to received one sachet daily for 12 weeks. Glycemic index, Lipid profile, and hs-CRP measured at the beginning of the study and the end of the 12th week. Results: After 12 weeks, supplementation means a change of Hip circumference (HC) significantly decreased in the synbiotic group compared to the placebo group (-0.85±1.89 vs. 1.23±3.98). Although systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the end of trial declined in the synbiotic group compared to baseline, respectively p=0.03, p=0.01. Analysis of covariance demonstrated that synbiotic supplementation during 12 weeks significantly reduced glycemic factors including fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) (p<0.05) and inflammatory index, hs-CRP (p<0.05) compared to placebo. Conclusion: The current study indicated Synbiotic supplementation could improve glycemic index, systemic inflammation and blood pressure in patients with type 2 diabetes. So correcting the intestinal microbial flora can be a new therapeutic approach to treating this disease. Trial registration: IRCT, IRCT20100524004010N27. Registered 7 January 2019, https://www.irct.ir/trial/36535

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“…14,15 There is evidence that lactic acid-producing bacteria, and especially the Bacillus species, remain stable in heat and maintain their activity after baking. 16 The stability of these bacteria is facilitated by the presence of heat-resistant spores. 17 Bacillus coagulans -B. coagulans (Lactobacillus sporogenes) is a gram-positive, spore-forming, facultative anaerobe, which resists high pressure and temperature, and can function as a probiotic of choice in nondairy products.…”

Section: Introductionmentioning

confidence: 99%

“…17 Bacillus coagulans -B. coagulans (Lactobacillus sporogenes) is a gram-positive, spore-forming, facultative anaerobe, which resists high pressure and temperature, and can function as a probiotic of choice in nondairy products. 16 Other probiotic microorganisms, such as Lactobacillus reuteri, Lactobacillus acidophilus and Bifidobacterium are not spore-forming, and therefore are sensitive to temperature, pressure and stomach acid. Bacillus coagulans is a probiotic approved by the U.S. Food and Drug Administration (FDA) for use in animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count

et al. 2019

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Background. Dental caries is considered the most common infectious disease in humans worldwide. Cariogenesis is the outcome of a complex interaction between the host's oral flora and diet. The consumption of snacks such as cake, which have the potential to promote dental caries, has increased.Objectives. The aim of this study was to investigate the effect of including probiotic bacteria (Bacillus coagulans -B. coagulans) in consumed snack cake on the Streptococcus mutans (S. mutans) count and salivary pH.Material and methods. We conducted a randomized, double-blind, cross-sectional cohort study on 40 healthy volunteers. The subjects were divided into 2 groups. In the 1 st group, the subjects consumed probiotic cake as breakfast for 1 week and then, following a 4-week wash-out period, consumed regular cake as breakfast for 1 week. In the other group, the administration of probiotic and regular cake was reversed. For both groups, samples of at least 5 mL of non-stimulated saliva were collected using the spitting technique before and after the 1 st and the 6 th week. A colony counter was used to determine the number of S. mutans colonies. Salivary pH was measured before eating (8-9 a.m.). Results.We detected no statistically significant difference in the S. mutans count before and after the consumption of probiotic cake, but noted a statistically significant difference in the count before and after the consumption of regular cake. We did not detect a significant difference in salivary pH with respect to the consumption of probiotic and regular cake, although the consumption of both foods caused a drop in salivary pH.Conclusions. The addition of probiotic bacteria to sweet snack cake caused a minimal increase in the salivary count of S. mutans, a bacterial species with a definite role in cariogenesis, but did not impact salivary pH. Since probiotic cake has a slight impact on the S. mutans count, it is preferred over regular cake as a snack food. Cite asKoopaie M, Fatahzadeh M, Jahangir S, Bakhtiari R. Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count.

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RETRACTED ARTICLE: The Consumption of Synbiotic Bread Containing Lactobacillus sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial

Abstract: In conclusion, consumption of the synbiotic bread for 8 weeks among patients with T2DM had beneficial effects on plasma NO and MDA levels; however, it did not affect plasma TAC, GSH, catalase levels, serum liver enzymes, calcium, iron, magnesium levels, and blood pressure.

Cited by 80 publications

References 49 publications

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

The effects of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study

Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count

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