RETRACTED ARTICLE: Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a

Zhang, Shun; Chen, Ping; Huang, Zuoan; Hu, Xiaorong; Chen, Mengting; Hu, Shanshan; Hu, Youjun; Cai, Ting

doi:10.1038/srep09787

Cited by 104 publications

(93 citation statements)

References 26 publications

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“…The mechanistic explanation of this phenomenon is unclear, but may involve an increased dissociation rate from the Argo2‐RISC complex. Moreover, miR‐34a's regulatory function is not limited to SIRT1 but extends to SIRT6 and −7 (105, 106). Therefore, it is very probable that a similarly rich network of interactions is true for the other sirtuins.…”

Section: Regulation Of Sirt1 By Micrornasmentioning

confidence: 99%

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Who watches the watchmen? Regulation of the expression and activity of sirtuins

2016

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Sirtuins (SIRT1-7) are a family of nicotine adenine dinucleotide (NAD)-dependent enzymes that catalyze post-translational modifications of proteins. Together, they regulate crucial cellular functions and are traditionally associated with aging and longevity. Dysregulation of sirtuins plays an important role in major diseases, including cancer and metabolic, cardiac, and neurodegerative diseases. They are extensively regulated in response to a wide range of stimuli, including nutritional and metabolic challenges, inflammatory signals or hypoxic and oxidative stress. Each sirtuin is regulated individually in a tissue- and cell-specific manner. The control of sirtuin expression involves all the major points of regulation, including transcriptional and post-translational mechanisms and microRNAs. Collectively, these mechanisms control the protein levels, localization, and enzymatic activity of sirtuins. In many cases, the regulators of sirtuin expression are also their substrates, which lead to formation of intricate regulatory networks and extensive feedback loops. In this review, we highlight the mechanisms mediating the physiologic and pathologic regulation of sirtuin expression and activity. We also discuss the consequences of this regulation on sirtuin function and cellular physiology.-Buler, M., Andersson, U., Hakkola, J. Who watches the watchmen? Regulation of the expression and activity of sirtuins.

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Section: Regulation Of Sirt1 By Micrornasmentioning

confidence: 99%

“…A reduced global acetylation signature of H3K18 is associated with aggressive tumor phenotypes and correlates with poor survival prognosis, suggesting that SIRT7 has a function in cancerogenesis (105, 227, 228). Indeed, SIRT7 expression is increased in several human tumors and correlates with tumor size in mice (228).…”

Section: Sirt7mentioning

confidence: 99%

Who watches the watchmen? Regulation of the expression and activity of sirtuins

2016

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“…Accumulating evidence points to the involvement of SIRT7 in the pathophysiological process of cardiac diseases, hepatic steatosis, and tumorigenesis . To date, little is known about the role of SIRT7 in cerebral ischemia/reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, SIRT7 improves cellular survival and suppresses apoptosis induced by genomic stress . Also, knockdown of SIRT7 induces apoptosis in cancer cells . SIRT7‐defcient mice exhibit susceptibility to cardiac rupture following myocardial infarction .…”

Section: Discussionmentioning

confidence: 99%

Sirtuin7 is involved in protecting neurons against oxygen‐glucose deprivation and reoxygenation‐induced injury through regulation of the p53 signaling pathway

Tian

Zheng

et al. 2017

J Biochem & Molecular Tox

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Sirtuin7 (SIRT7) is known to regulate apoptosis and stress responses. So far, very little is known about the role of SIRT7 in cerebral ischemia/reperfusion injury. In this study, we aimed to investigate the potential role of SIRT7 in regulating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury in neurons. We found a significant increase of SIRT7 expression in neurons in response to OGD/R treatment. Knockdown of SIRT7 aggravated OGD/R-induced injury. Knockdown of SIRT7 augmented the levels of total and acetylated p53 protein. Moreover, knockdown of SIRT7 markedly increased the transcriptional activity of p53 toward apoptosis and activated the p53-mediated proapoptotic signaling pathway. By contrast, overexpression of SIRT7 showed the opposite effects. Taken together, the results of our study suggest that SIRT7 is involved in protecting neurons against OGD/R-induced injury, possibly through regulation of the p53-mediated proapoptotic signaling pathway, indicating a potential therapeutic target for cerebral ischemia/reperfusion injury.

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“…In line with this, SIRT7 has been also described to act as an oncogene in hepatocellular carcinoma, gastric cancer and colorectal cancer [140][141][142]. As other sirtuins, SIRT7 also regulates HIF proteins, potentially underlying the Warburg effect.…”

Section: Page 19 Of 46mentioning

confidence: 95%

The role of mammalian sirtuins in cancer metabolism

Sebastián

Mostoslavsky

2015

Seminars in Cell & Developmental Biology

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Metabolic reprogramming has recently emerged as a key feature of cancer cells, which need to rewire their cellular metabolism in order to sustain their faster proliferation and growth. New insight into the molecular mechanisms governing this metabolic reprogramming has implicated mammalian sirtuins as important regulators of cancer metabolism. Sirtuins are NAD(+)-dependent protein deacylases involved in a variety of biological functions, including life span and health span regulation, genomic stability, tumorigenesis, inflammation, and metabolism. Due to the requirement of NAD(+) for their function, sirtuins can act as sensors of the metabolic state of the cell and regulate core metabolic pathways in response to cellular stresses, thus being good candidates to control the reprogramming of cellular metabolism that occurs during tumorigenesis. Here, we summarize our current knowledge of the roles of mammalian sirtuins in cancer metabolism, and discuss their implication in controlling this metabolic shift during aging and aging-associated cancers.

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RETRACTED ARTICLE: Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a

Cited by 104 publications

References 26 publications

Who watches the watchmen? Regulation of the expression and activity of sirtuins

Who watches the watchmen? Regulation of the expression and activity of sirtuins

Sirtuin7 is involved in protecting neurons against oxygen‐glucose deprivation and reoxygenation‐induced injury through regulation of the p53 signaling pathway

The role of mammalian sirtuins in cancer metabolism

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