RETRACTED ARTICLE: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Dai, Lei; Cui, Xueliang; Zhang, Xin; Cheng, Lin; Liu, Yi; Yang, Yang; Fan, Ping; Wang, Qingnan; Lin, Yi; Zhang, Junfeng; Li, Chunlei; Mao, Ying; Wang, Qin; Su, Xiaolan; Zhang, Shuang; Peng, Yong; Yang, Huiling; Hu, Xun; Yang, Jinliang; Huang, Meijuan; Xiang, Rong; Yu, Dechao; Zhou, Zong‐Guang; Wei, Yuquan; Deng, Hongxin

doi:10.1038/ncomms11996

Cited by 90 publications

(88 citation statements)

References 41 publications

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“…12 A previous study by our group indicated that the down-regulation of SARI inversely correlates with poor clinical outcomes in colon cancer patients. 15 In the present study, a decrease in intestinal SARI mRNA and protein expression accompanied the DSS treatment in the CAC model. Interestingly, injection of AOM significantly enhanced SARI expression both at the mRNA and protein level.…”

Section: Discussionsupporting

confidence: 51%

“…14 The previous study by us demonstrated that SARI inhibiting tumour angiogenesis and colon tumour growth through directly targeting ceruloplasmin and inhibiting the HIF-1α/VEGF axis. 15 A recent study by us also determined the anti-tumour role of SARI-targeted demethylation system by inhibiting tumour proliferation, angiogenesis and promoting apoptosis in colon cancer. 16 However, the role of SARI in tumour-associated inflammation microenvironment is still elusive.…”

Section: Introductionmentioning

confidence: 99%

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SARI suppresses colitis‐associated cancer development by maintaining MCP‐1‐mediated tumour‐associated macrophage recruitment

Dai

Liu

Yin

et al. 2019

J Cellular Molecular Medi

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SARI (suppressor of AP‐1, regulated by IFN) impaired tumour growth by promoting apoptosis and inhibiting cell proliferation and tumour angiogenesis in various cancers. However, the role of SARI in regulating tumour‐associated inflammation microenvironment is still elusive. In our study, the colitis‐dependent and ‐independent primary model were established in SARI deficiency mice and immuno‐reconstructive mice to investigate the functional role of SARI in regulating tumour‐associated inflammation microenvironment and primary colon cancer formation. The results have shown that SARI deficiency promotes colitis‐associated cancer (CAC) development only in the presence of colon inflammation. SARI inhibited tumour‐associated macrophages (TAM) infiltration in colon tissues, and SARI deficiency in bone marrow cells has no observed role in the promotion of intestinal tumorigenesis. Mechanism investigations indicated that SARI down‐regulates p‐STAT1 and STAT1 expression in colon cancer cells, following inhibition of MCP‐1/CCR2 axis activation during CAC development. Inverse correlations between SARI expression and macrophage infiltration, MCP‐1 expression and p‐STAT1 expression were also demonstrated in colon malignant tissues. Collectively, our results prove the inhibition role of SARI in colon cancer formation through regulating TAM infiltration.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

SARI suppresses colitis‐associated cancer development by maintaining MCP‐1‐mediated tumour‐associated macrophage recruitment

Dai

Liu

Yin

et al. 2019

J Cellular Molecular Medi

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“…Several cytokines, including VEGF, VEGF‐C, VEGF‐D, bFGF, and HGF, play a crucial role during tumor growth and angiogenesis . Inhibition of VEGF by upstream targets or neutralizing antibodies could efficiently inhibit tumor growth and cancer cell metastasis . In ovarian cancer, VEGF was upregulated and correlated with the clinical stage of the disease .…”

Section: Discussionmentioning

confidence: 99%

LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR‐145

Lin

Yang

et al. 2019

Molecular Carcinogenesis

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Differentiation antagonizing non‐protein coding RNA (DANCR) is a newly identified oncogenic long noncoding RNA found in various cancers. However, the functional role of DANCR in tumor angiogenesis and the underlying mechanisms are still unclear. The expression of DANCR was determined in ovarian malignant tissues and cell lines. The functional role of DANCR in tumor angiogenesis was revealed by the following methods: CD31 staining of ovarian tumor tissues, matrigel‐plug assay tissues, HUVEC‐related tube formation assay, and invasion assay. Enzyme‐linked immunosorbent assay, Western blotting, luciferase assay, and rescue experiments were used to investigate the underlying mechanisms of DANCR‐regulating angiogenesis. DANCR was upregulated in ovarian malignant tissues and ovarian cancer cells. Knockdown of DANCR efficiently impaired ovarian tumor growth through inhibition of tumor angiogenesis. Furthermore, the conditional culture medium from DANCR‐knockdown ovarian cells significantly inhibited tube formation and invasion of HUVEC in vitro. Mechanistic investigation indicated that vascular endothelial growth factor A (VEGF‐A, VEGF) plays a crucial role during DANCR inhibition of tumor angiogenesis in ovarian cancer. Further results demonstrated that miR‐145 is the direct binding target of DANCR during regulation of VEGF expression and tumor angiogenesis in ovarian cancer cells. Collectively, DANCR plays a promotional role in tumor angiogenesis in ovarian cancer through regulation of miR‐145/VEGF axis. Therefore, DANCR may be a novel therapy target for ovarian cancer.

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“…The invasion of 4T1 cells was evaluated using Transwell-24 units (pore size, 8 µm; EMD Millipore), as described previously with some modification (11). Briefly, the filter of the Transwell plate was covered with 50 µl matrigel (BD Biosciences, Franklin Lakes, NJ, USA).…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-376b promotes breast cancer metastasis by targeting Hoxd10 directly

Luo

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Breast cancer is the most common malignant disease in women, and metastasis formed at distant anatomic sites was the major cause of cancer-related mortality. Thus, a novel therapy target and progression biomarker for breast cancer metastasis was necessary. microRNA (miR)-376b has been demonstrated to regulate angiogenesis; however, its role in cancer metastasis remains elusive. In the present study, the expression of miR-376b in normal breast tissue, JC and 4T1 cells was determined by qPCR. Furthermore, in vitro and in vivo experiments were performed to determine the effect of miR-376b on breast cancer metastasis. The direct target of miR-376b was determined by the luciferase assay and western blotting. The results indicated that silencing of miR-376b by the miR-376-mimic significantly inhibited 4T1 cell migration and invasion in vitro. Lung metastasis was also evidently decreased after silencing of miR-376b in 4T1 cells. Moreover, the luciferase assay and western blotting identified that Hoxd10 is the direct target of miR-376b during the regulation of breast cancer metastasis. To the best of our knowledge, the present study was the first to demonstrate the promoting breast cancer metastasis role of miR-376b by directly targeting Hoxd10. Therefore, it would be a novel therapy target and prognostic biomarker for breast cancer.

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RETRACTED ARTICLE: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Cited by 90 publications

References 41 publications

SARI suppresses colitis‐associated cancer development by maintaining MCP‐1‐mediated tumour‐associated macrophage recruitment

SARI suppresses colitis‐associated cancer development by maintaining MCP‐1‐mediated tumour‐associated macrophage recruitment

LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR‐145

MicroRNA-376b promotes breast cancer metastasis by targeting Hoxd10 directly

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