Retracted Article: PVT1 knockdown alleviates vancomycin-induced acute kidney injury by targeting miR-124 <i>via</i> inactivation of NF-κB signaling

Zhu, Xiaodong; Shi, Jun; Li, Huicong; Chen, Fang

doi:10.1039/c8ra05724a

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Curcumin could protect LPS-induced septic acute kidney injury by suppressing PVT1 expression [ 12 ]. Moreover, PVT1 knockdown targets miR124 to improve vancomycin-induced acute kidney injury through the activation of NF-κB signaling [ 14 ]. Therefore, PVT1 can promote the development of LPS- and vancomycin-induced kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of lncRNA-PVT1 participates in the development of progressive chronic kidney disease among patients with congestive heart failure

et al. 2021

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Background Congestive heart failure (CHF) is a major cause of the development of progressive chronic kidney disease (CKD), while the mechanism is still unknown. LncRNA PVT1 contributes to kidney injury. This study aimed to explore the role of PVT1 in the development of CKD in CHF patients. Methods Expression of PVT1 in plasma samples of CHF patients with and without CKD was determined by RT-qPCR. The diagnostic value of plasma PVT1 for CKD was evaluated by ROC curve analysis. The predictive value of PVT1 for the development of CKD in CHF patients was analyzed by a 2-year follow-up study. Changes in PVT1 expression in CKD patients during treatment were analyzed by RT-qPCR and reflected by heatmaps. Results Plasma PVT1 was downregulated in CHF and further downregulated in CHF patients complicated with progressive CKD. ROC curve analysis showed that plasma PVT1 levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. During a 2-year follow-up, patients with high CHF levels had a low incidence of progressive CKD among CHF patients. Moreover, with the treatment of progressive CKD, plasma PVT1 was upregulated. Conclusions LncRNA-PVT1 downregulation may participate in the development of progressive CKD among patients with CHF.

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Section: Discussionmentioning

confidence: 99%