“…The mechanisms by which Rho-associated coiled coil-containing protein kinases (ROCKs) participate in tumor progression, especially in the stages of tumorigenesis, tumor development and metastasis, remain a focus of current research [5][6][7] . It has been reported that the ROCK isomer ROCK1 is highly expressed during breast cancer metastasis, thus enhancing the aggressiveness of cancer cells, and its overexpression was found to be signi cantly negatively correlated with the survival rate of patients 8,9 .…”