RETRACTED ARTICLE: Oral micronised flavonoids versus tranexamic acid for treatment of heavy menstrual bleeding secondary to copper IUD use: a randomised double-blind clinical trial

Alanwar, Ahmed; Abbas, Ahmed M.; Hussain, Sherif Hanafi; Elhawwary, Gihan E; Mansour, Dina Yahia; Faisal, Malames M.; Elshabrawy, Amal; Eltaieb, E

doi:10.1080/13625187.2018.1515349

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…18 Finally, food intake does not affect time to maximum concentration, as detected by the area under the receiver operating characteristic curve (ROC AUC). [16][17][18]28 Compared to the other lysine analog epsilon-aminocaproic acid, TXA is up to ten times more potent in binding affinity to plasminogen. Moreover, TXA provokes inhibition of fibrinolysis, which manifests as reductions in serum D-dimer levels without affecting the results of serum markers of coagulopathy.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

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Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research

Zec¹,

Napoli²,

Fiévez³

et al. 2022

JMDH

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In cancer patients undergoing surgery, tumor biology and anticancer treatments can increase the risk of perioperative bleeding and blood transfusions. Notably, blood transfusions can be potentially associated with an increased risk of life-threatening immune responses, acute lung injury, postoperative infections, and thromboembolism. Moreover, the link between perioperative transfusion and increased risk of cancer recurrence cannot be excluded. On the other hand, cancer patients have an increased risk of thromboembolism due to cancer itself and antineoplastic systemic treatments including chemotherapy and anti-angiogenic drugs. In this complex scenario, effective and safe strategies aimed at the prevention of blood transfusions are warranted. This narrative review addresses the efficacy, and the safety of the synthetic antifibrinolytic agent tranexamic acid (TXA) when used perioperatively in cancer surgery. Although in not oncologic surgery the use of TXA has been extensively studied, in the setting of cancer patients requiring surgery, the evidence is scarce. An overview of the ongoing clinical research is also provided.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

“… 18 Finally, food intake does not affect time to maximum concentration, as detected by the area under the receiver operating characteristic curve (ROC AUC). 16–18 , 28 …”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research

Zec¹,

Napoli²,

Fiévez³

et al. 2022

JMDH

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“…Alanwar et al conducted a randomised double-blind clinical trial: oral micronised flavonoids versus tranexamic acid for treatment of HMB secondary to copper IUD use. 9 Mean PBAC scores were significantly improved in the tranexamic acid group compared with the micronised flavonoids group (236±48, 105±26, 97±16 and 93±15 at the baseline, first, second and third study cycle, respectively, versus 227±52, 139±29, 128±25 and 125±24 in the micronised flavonoids group; p=0.01). Moreover, the number of bleeding days and number of pads used were significantly reduced in the tranexamic acid group compared with the micronised flavonoids group.…”

Section: Discussionmentioning

confidence: 87%

Diosmin versus tranexamic acid in heavy menstrual bleeding: a randomized controlled trial

Gupta

Das²,

Dalai³

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Heavy menstrual bleeding (HMB) is defined as cyclical bleeding at regular intervals but excessive in amount which affect the physical, social and mental aspects of life of a woman. The prevalence is 10-30% in reproductive age women and 50% in perimenopausal women. HMB is not just a clinical burden but also a huge social and economic burden. The aims and objective of my study is to compare the efficacy of diosmin and tranexamic acid in acute HMB in terms of average duration of menstrual cycle, PBAC/PABC score, endometrial thickness, hemoglobin concentration and finally need for other modes of treatment.Methods: The study was a randomized control trial in which the patients (sample size-72) were divided into two groups- group D (n=36) and group T (n=36). Group D was treated with tab diosmin 500 mg thrice daily from day 1 to day 5 of menstrual cycle. Similarly group T was treated with tab tranexamic acid 500 mg thrice daily from day 1 to day 5 of menstrual cycle. The PBAC score was taken at the end of three months along with endometrial thickness and hemoglobin concentration. The results were compared with values obtained before initiating treatment.Results: In this study after 3 months of treatment; the patients in group D had an initial PBAC score of 423.52 and at the end of treatment it was decreased to 149.89 (p<0.0001). Reduction was 60.5%. Group T patients had an initial PBAC score of 441which was reduced to 177.94 (p<0.0001) after treatment. The reduction in this group was 59.6%.Conclusions: In this study it was found that both tranexamic acid and diosmin were effective in reduction of HMB, in terms of PBAC score, average duration of menstrual cycle and endometrial thickness. But the in reduction in PBAC score was similar in both the groups. The failure rates were also similar in both the groups, but improvements in hemoglobin concentration were only marginal

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“…They have also been shown to lessen capillary hyperfragility and enhance lymphatic outflow. [25][26][27] The Vit C present in Hibiscus rosa-sinensis Linn. can cause a diminution in the duration of the menstrual periods and an increase in haemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Effect of Japakusuma mukula (flower buds of Hibiscus rosa-sinensis Linn.) with Ksheera in Asrigdhara – A case report.

2023

KJA

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Asrigdhara (abnormal uterine bleeding), which manifests as profuse vaginal bleeding, has existed for centuries and has been known to humans from the time of the Vedas and Puranas. Asrigdhara can be defined as excessive or extended bleeding during menstruation or even minimal bleeding during the interim between cycles. While considering the symptoms of Asrigdhara, it can be compared with abnormal uterine bleeding which broadly refers to menstrual irregularities outside of pregnancy that affect frequency, regularity, length and flow volume. In the famous Ayurvedic book Chikitsamanjari and the classical textbook Gada Nigraha in the context of Asrigdhara, it is said that about 10-12 Japakusuma mukula (flower buds of Hibiscus rosa-sinensis Linn.) along with ksheera (milk) is very effective in treating the specific condition of excessive uterine bleeding. A clinical case of Asrigdhara was selected as per the inclusion and exclusion criteria and was given medication orally in the form of 1.5 grams of bhavitha choorna (triturated powder) of Japakusuma mukula mixed with 4 times ksheera, one hour before food for 5 days from the first day of menstruation for three consecutive menstrual cycles. Assessment of the reduction in the symptoms was made as per the PBAC scale and the associated symptoms such as an increase in the duration of bleeding, irregularities in the menstrual cycle, pain and fatigue were assessed as per the four-point vertebral scale. The follow-up was also done for 3 months to analyse whether the static effect of the drug continued. The case study revealed a significant reduction in bleeding and passing of clots during menstruation, while its effect gradually declined during the follow-up period.

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RETRACTED ARTICLE: Oral micronised flavonoids versus tranexamic acid for treatment of heavy menstrual bleeding secondary to copper IUD use: a randomised double-blind clinical trial

Cited by 6 publications

References 15 publications

Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research

Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research

Diosmin versus tranexamic acid in heavy menstrual bleeding: a randomized controlled trial

Effect of Japakusuma mukula (flower buds of Hibiscus rosa-sinensis Linn.) with Ksheera in Asrigdhara – A case report.

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