RETRACTED ARTICLE: Nicorandil accelerates recovery of neuromuscular block caused by vecuronium

Saitoh, Yuhji; Kaneda, Koh; Fujii, Yoshitaka; Oshima, Tsutomu

doi:10.1007/bf03019810

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…On the other hand, when the degree of neuromuscular blockade is intense, nicorandil presumably cannot open the blocked K ATP channel. As the level of neuromuscular blockade weakens, the K ATP channel may open and K + conductance is enhanced [48]. For this reason, the nicorandil-induced effect on neuromuscular blockade might have been significant, as the degree of neuromuscular blockade subsided in our study.…”

Section: K Atp Channel Agonist (Nicorandil)mentioning

confidence: 91%

“…Spuler et al [46] reported that, in the absence of neuromuscular relaxant, K ATP Values are the mean ± SD Time to the returns of T1, T2, T3, or T4, and time to the recovery of T1/control to 0.25 or 0.50, and time to the recovery of TOF ratio to 0.25 or 0.50 in the milrinone group were significantly shorter than in the control group (P < 0.05) channel agonist enhanced muscular response rapidly in patients who had the following diseases: myotonic dystrophy, chondrodystrophic myotonia, hypokalemic periodic paralysis, recessive generalized myotonia, amyotrophic lateral sclerosis, and myositis and in patients without neurological diseases. We studied the effect of nicorandil on the recovery from neuromuscular blockade after administration of vecuronium in anesthetized patients [48]. Before induction of anesthesia, a bolus dose of nicorandil 0.1 mg·kg -1 was administered followed by a continuous infusion at a rate of 1 mg·kg -1 ·min -1 .…”

Section: K Atp Channel Agonist (Nicorandil)mentioning

confidence: 99%

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Drugs to facilitate recovery of neuromuscular blockade and muscle strength

Saitoh¹

2005

J Anesth

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Several drugs that quicken recovery from neuromuscular blockade caused by vecuronium in anesthetized patients are reviewed. Ulinastatin, a protease inhibitor, is thought to promote the release of acetylcholine at the neuromuscular junction and increases hepatic blood flow and urine volume. For this reason, ulinastatin quickens recovery from neuromuscular blockade in anesthetized patients receiving vecuronium. Additionally, pretreatment with ulinastatin avoids prolongation of vecuronium-induced neuromuscular blockade in patients with hepatic cirrhosis. Gabexate mesilate is also a protease inhibitor. During a continuous infusion of gabexate mesilate, recovery from neuromuscular blockade was quickened. Amino acid-enriched solution supplies energy to the skeletal muscles and causes an increase in muscle strength. An infusion of amino acid-enriched solution hastens recovery from neuromuscular blockade in anesthetized patients. When amino acids supply energy to the skeletal muscles, they simultaneously produce heat in the skeletal muscles. This thermal generation may be closely related to fast recovery from neuromuscular blockade. Amino acid-enriched solution makes recovery from neuromuscular blockade quick and avoids hypothermia during general anesthesia. Milrinone, a phosphodiesterase III inhibitor, is supposed to increase the release of acetylcholine at the neuromuscular junction and make the neuromuscular junction sensitive to acetylcholine. Therefore, recovery from neuromuscular blockade is hastened. Nicorandil enhances membrane K+ conductance in skeletal muscle and increases contraction of the skeletal muscle. Thus, nicorandil quickens recovery from neuromuscular blockade.

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Section: K Atp Channel Agonist (Nicorandil)mentioning

confidence: 91%

Section: K Atp Channel Agonist (Nicorandil)mentioning

confidence: 99%